Malonic dialdehyde in the cerebrospinal fluid in intracranial hypertension.
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Humans↗
Biomedical subjects
M Turgut
Publications and source records attributed to M Turgut.
Trigeminal neurinomas in infants.
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Adolescent↗
Huge ossified crust-like subdural hematoma covering the hemisphere and causing acute signs of increased intracranial pressure.
We report the successful removal of an ossified crust-like chronic subdural hematoma (SDH) covering the hemisphere in a 16-year-old boy. In this article, the importance of the surgical approach is stressed, and the rarity of this condition in the neurosurgical literature is also outlined.
Adolescent↗
Lumbosacral plexus compression by fetus: an unusual cause of radiculopathy during teenage pregnancy.
A case is reported of a lumbosacral plexus compression by the fetus in a young 34-weeks pregnant woman, who had low-back pain and progressive muscular weakness of the leg. Neurological examination showed a grade IV motor weakness of the iliopsoas, quadriceps femoris and biceps femoris muscles. Mechanical stretch manoeuvers were negative. Electromyography revealed denervation activity in L4 and L5 muscles. Lumbosacral plexus radiculopathy was diagnosed. Although fetal compression appears to be an uncommon cause of lumbosacral radiculopathy during teenage pregnancy, both neurosurgeons and obstetricians should be aware of the possibility.
Adolescent↗
Meningiomas in childhood and adolescence: a report of 13 cases and review of the literature.
Meningiomas are relatively uncommon in childhood. They represent 1 to 2% of all intracranial tumours of infancy and childhood. During the last 30-year period, from 1964 to 1993, 13 children with a diagnosis of meningioma were operated on at the Department of Neurosurgery, Hacettepe University School of Medicine. The meningiomas in the paediatric age group were characterized by multiplicity (23%), frequent association with neurofibromatosis (23%), intraventricular location (8%), and the presence of a cystic component in the tumour tissue (23%). These findings in children differ from those in adults. This study constitutes a retrospective analysis of these cases and a review of the literature.
Adolescent↗
Intradural tuberculous granuloma.
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Humans↗
Serum vitamin A and beta-carotene levels in children with recurrent acute respiratory infections and diarrhoea in Malatya.
Deficiency of serum vitamin A is one of the widespread public health problem among pre-school children in developing countries. A limited number of studies have been done about this problem in Turkey and there is no similar work done in Malatya. Serum vitamin A and beta-carotene levels in 56 pre-school age children who had recurrent acute respiratory infections (ARI) or recurrent diarrhoea were determined by a UV/VIS spectrometer. The results obtained were compared with 35 healthy pre-school age children. Serum vitamin A (51.66 +/- 8.10 micrograms/dL) and beta-carotene (82.88 +/- 18.5 micrograms/dL) levels in children with ARI's were found significantly lower than the control group (58.14 +/- 9.07 micrograms/dL and 131.43 +/- 22.38 micrograms/dL, respectively) (P < 0.001). Serum vitamin A (47.21 +/- 8.27 micrograms/dL) and beta-carotene (81.63 +/- 15.41 micrograms/dL) levels in children with recurrent diarrhoea were also found significantly lower than the control group (58.14 +/- 9.07 micrograms/dL and 131.43 +/- 22.38 micrograms/dL, respectively) (P < 0.001).
Acute Disease↗
Secondary multiple intracranial hydatid cysts caused by intracerebral embolism of cardiac echinococcosis: an exceptional case of hydatidosis. Case report.
The authors present an extremely rare case of secondary multiple cerebral echinococcosis caused by presumed intracerebral and arterial embolism of cardiac hydatidosis in a 7-year-old girl. The first manifestations were symptoms of raised intracranial pressure. Unfortunately, before the primary ruptured echinococcosis cyst was detected in the myocardium of the left ventricle, the patient underwent nine operations over an 8-year period for hydatid embolism affecting the brain and the femoral artery and was treated with concurrent mebendazole therapy. The combined therapy would not have been successful without removal of the intracardiac hydatid cyst. This case is unusual because of the multiplicity of intracranial hydatid cysts and its embolic origin from cardiac echinococcosis. The present case is believed to be the first one in which the development of an embolism in the brain was studied by magnetic resonance imaging.
Brain Diseases↗
Primary intracranial extradural hydatid cyst extending above and below the tentorium.
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Albendazole↗
Giant schwannoma of the trigeminal nerve misdiagnosed as maxillary sinusitis. A case report.
A 24-year-old woman presented with left-sided ptosis, diplopia, sensory impairment on the left side of her face and diminished hearing in her left ear. The neurological findings were hypo-anesthesia in all three divisions of the trigeminal nerve, left-sided facial paralysis of the oculomotor and abducens nerves. Initially the condition was misdiagnosed as maxillary sinusitis and was treated with antibiotics. It seems that this presentation has not been previously described in commonly read English-language journals. In our case, the tumour was removed totally and the neuropathological diagnosis was schwannoma. The case report describes the presentation, investigations, management and outcome in this patient.
Adult↗
Spinal injuries in the pediatric age group: a review of 82 cases of spinal cord and vertebral column injuries.
A review of 82 children with spinal cord and/or vertebral column injury treated in our department between 1968 and 1993 showed that 67% of the patients were boys and the average age was 11.4 years. The cause, vertebral level, and type of injury, and the severity of neurological injury varied with the age of the patient. The cause of pediatric injuries differed from that of adult injuries in that falls were the most common causative factor (56%) followed by vehicular accidents (23%). The most frequent level of spinal injury was in the cervical region (57%, 47 patients) followed by the lumbar region (16.5%, 13 patients). In our series, 18% of the patients had complete injury and the overall mortality rate was 3.6%. Eleven children (13%) had spinal cord injury without radiographic abnormality (SCIWORA), whereas 39 (47%) had evidence of neurological injury. Although the spinal injury patterns differed between children and adolescents, the outcome was found to be predominantly affected by the type of neurological injury (P < 0.05). Children with complete myelopathy uniformly remained with severe neurological dysfunction; children with incomplete myelopathy recovered nearly normal neurological function. Finally, the authors conclude that most spinal injuries can be successfully managed with nonoperative therapy. The literature is reviewed as to the treatment and outcome of pediatric spinal injuries.
Child↗
Effect of Nd:YAG laser on experimental disc degeneration. Part I. Biochemical and radiographical analysis.
Intervertebral disc herniation is an important health problem from both the social and economic aspect. It is often accompanied by a decrease in the content of water and proteoglycan (PG). The present study was undertaken to elucidate the effect of neodymium-yttrium-aluminum-garnet (Nd:YAG) laser on degenerated disc tissue. In this study a ventral disc herniation model in guinea pigs was performed to study the effects of ND:YAG laser on degenerated disc with low water and PG content. Effect of ND:YAG laser on degenerated cervical disc tissue is examined from the aspects of biochemistry and radiology. In the acute period water, PG, and collagen content decreased due to the ablative effect of ND:YAG laser on disc tissue. When changes in the degenerated disc in the post-laser chronic period were compared with degenerated disc findings, statistically significant changes could not be be found. From the results of this study, there is no question that the Nd:YAG laser offers many potential benefits, it remains to be proven whether or not this is of real benefit in the treatment of patients with degenerated disc disease.
Analysis of Variance↗
Effect of Nd:YAG laser on experimental disc degeneration. Part II. Histological and MR imaging findings.
The potential advantages of percutaneous procedures over traditional discectomy are multiple, but the use of laser energy to ablate disc tissue appears entirely empirical. To date, no experimental study exists investigating the results of laser on degenerated intervertebral disc. The present study was therefore undertaken to determine the histological and radiological changes induced by neodymium-yttrium-aluminum-garnet (Nd:YAG) laser on such disc tissue. It was shown that the vaporization of disc tissue was caused by Nd:YAG laser in early period, but this was gradually replaced by cartilaginous fibrous tissue at 60 days after laser irradiation as a result of the proliferation of cartilaginous cells and fibrous tissues. Accordingly the magnetic resonance (MR) imaging index histogram moved to the left in the early period, but it moved to the right again at 60 days after laser irradiation. In view of these data, we conclude that the use of laser in degenerated disc disease does not represent an effective treatment as an alternative to conventional surgical methods.
Animals↗
Subependymal giant cell astrocytoma associated with tuberous sclerosis: diagnostic and surgical characteristics of five cases with unusual features.
Five children with tuberous sclerosis and intracranial tumors were surgically treated at Neurosurgery Department of Hacettepe University School of Medicine. Two of the five patients presented with the giant cell astrocytoma filling the third ventricle. Direct surgical intervention and tumor removal was carried out in all four patients (three with a total surgical resection and one with a subtotal resection) and cerebrospinal fluid shunting procedure in one. Histopathological examination revealed giant cell astrocytomas in four patients. Postoperatively, one died and the rest four patients survived with minor focal neurologic difficulties. The surgical results and the changing concepts in the treatment of tuberous sclerosis are discussed and the literature is reviewed.
Adolescent↗
Twenty-five years experience in the treatment of trigeminal neuralgia. Comparison of three different operative procedures in forty-nine patients.
A series of 49 patients with trigeminal neuralgia (TN) were treated by three different surgical procedures: (1) peripheral ablative procedures in 10 patients; (2) percutaneous rhizotomy in 17 patients and (3) intracranial rhizotomy (IR) in 22 patients. On the basis of surgical treatment, the concept that neurovascular compression is a mechanical factor in the aetiology of TN was supported in 14 to 18 patients who underwent posterior fossa exploration. The results support the conclusion that retromastoid craniectomy with IR is the procedure of choice for the majority of patients with TN.
Adult↗
Factors affecting morbidity and mortality following surgical intervention in patients with intracranial meningioma.
BACKGROUND: Meningiomas usually grow slowly but they may cause recurrences despite surgical resection. The impact of clinical, neuroradiological and surgical characteristics on operative morbidity and mortality of patients operated on for intracranial meningioma was analysed. METHODS: A series of 450 patients operated on for intracranial meningiomas at the Department of Neurosurgery, Hacettepe University Hospital during the period 1964-1992 is reported. The surgical results were analysed with regard to intracranial site, extent of removal, histological type, and different time periods. Computed tomography (CT) and magnetic resonance imaging (MRI) facilitated the diagnosis and helped with the planning of treatment. RESULTS: Two hundred and ninety-two patients were examined with both CT and MRI. Overall mortality was 4% but showed a decline from 9% in the pre-CT era to 3% in the post-CT era and to 1% in the past 3 years. CONCLUSIONS: Operative mortality and recurrence rates are affected by the intracranial location of the tumour, histological type, and extent of tumour removal. Emphasis is also given to the importance of the introduction of the imaging techniques, and the microsurgical techniques with the Cavitron ultrasonic surgical aspirator (CUSA), laser, and/or bipolar coagulator which have further improved the operative mortality and recurrence rates.
Adolescent↗
Spontaneous cerebellar strokes. Clinical observations in 60 patients.
This is a retrospective study carried out by clinical analysis of the authors' experience in 60 patients with cerebellar strokes--of which 39 were spontaneous cerebellar hemorrhage and 21 were cerebellar infarction--to compare the clinical presentation, course, and prognosis. Hypertension was found to be the most important etiologic factor. Clinical differentiation of cerebellar hemorrhage from infarction was not possible, but the management was similar in both entities. Computerized tomography was necessary to make diagnosis of the stroke mechanism. In evaluating outcome, the authors conclude that the most important single factor affecting the prognosis was the early correct diagnosis.
Adolescent↗