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Biomedical subjects

M Tsuchiya

Publications and source records attributed to M Tsuchiya.

At least 541 records · Page 30Linked to original sources
PubMed1982

Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis.

The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was of significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% of the patients vs. 31% of controls [chi 2 = 13.4, p less than 0.001, corrected p less than 0.01, relative risk = 5.1). In addition, an increased frequency of HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (chi 2 = 10.84, p less than 0.001).

Adolescent↗
PubMed1982

Characterization of immunoregulatory T cells and lymphocytophilic antibodies in ulcerative colitis: analysis with monoclonal antibodies.

Using monoclonal antibodies to the surface antigens or suppressor/cytotoxic (Anti-Leu-2a) and helper/inducer (Anti-Leu-3a) T cell subsets, we characterized peripheral lymphocytes in 27 patients with ulcerative colitis (UC) and 15 age-matched healthy controls by a fluorescence activated cell sorter. The patients with active UC had a reduced percentage (8.2 +/- 3.6%) of Anti-Leu-2a reactive subset in comparison with healthy controls (24.6 +/- 3.6%) (P less than 0.01). No significant change was found in the percentage of Anti-Leu-3a reactive T cells between the patients and the controls. Moreover, the relationship of lymphocytophilic antibodies found in the patients with UC to the T cell subsets was also examined. After a fraction of normal T cells was eliminated with treatment of the sera from patients with active UC, the percentage of T cells reactive with Anti-Leu-2a decreased from 25 to 15%, whereas the percentage of T cells reactive with Anti-Leu-3a increased from 40 to 70%. In the reciprocal study, the lymphocytophilic antibodies reacted with 80% of Leu-3a negative T cells and 65% of Leu-2a negative T cells. These results demonstrated that the lymphocytophilic antibodies found in UC patients are reactive with suppressor T cells and thus play an important role in the loss of peripheral suppressor cells in the active UC patients. The lymphocytophilic antibodies were also demonstrated to be reactive with non-helper, non-suppressor T cell subsets and some populations of helper T cells. These studies suggest the presence of immune-regulatory disturbances contributing the pathogenesis of UC.

Adult↗
PubMed1982

Anti-colon antibody and lymphocytophilic antibody in ulcerative colitis.

The presence of anti-colon antibody in the sera from patients with ulcerative colitis was demonstrated by antibody-dependent cell-mediated cytotoxicity (ADCC) assay. In addition, the high prevalence of lymphocytophilic antibody in the sera from patients with ulcerative colitis was obtained by fluorescence activated cell sorter (FACS) analysis. This lymphocytophilic antibody was absorbed by rat colon epithelial cells. Moreover the lymphocytes from ulcerative colitis showed lower binding capacity to this antibody, but acquired higher binding capacity after 20 hr incubation at 37 degrees C in vitro. These data suggest that ADCC may have some role in the pathogenesis of ulcerative colitis.

Antibodies↗
PubMed1982

[Hemodynamic significance of the A/E ratio and B-B' step formation on the mitral valve echogram in patients with myocardial infarction].

We evaluated the hemodynamic significance of a B-B' step (shoulder) formation and the A/E ratio of the mitral valve echogram in 31 cases with myocardial infarction. Left ventricular (LV) motion and pressures were analyzed by cardiac catheterization, and were compared with the value of the A/E ratio and the presence or absence of the B-B' step. The B-B' step with its ratio to A wave of 0.5 or more in height was regarded as abnormal: 1) A LV pressure increase by atrial contraction was greater than 10 mmHg in 10 cases with abnormal B-B' step, whereas it was smaller than 9 mmHg in 14 cases without the abnormal B-B' step. 2) While the abnormal B-B' step was recognized in all seven cases who showed akinesis of the LV wall motion in both the anterior and apical portions, it was not seen in 12 of 13 cases who showed hypokinesis in both areas. The B-B' step was also seen in four of six cases who showed diffuse hypokinesis (more than 3 areas of LV wall segments by definition of the American Heart Association). 3) The B-B' step was not seen in any cases with the A/E ratio greater than 0.85 and all these cases had hypokinetic areas less than two segments. In contrast, the B-B' step was recognized in five of six cases with the A/E ratio smaller than 0.7. They had extensive hypokinetic areas more than three segments. We conclude that a B-B' step and the A/E ratio of the mitral valve echogram would be valuable indicators suggesting decreased left ventricular diastolic compliance and is useful in predicting the severity and extent of myocardial asynergy in cases with myocardial infarction.

Blood Pressure↗
PubMed1981

Experience with free composite tissue transplantation based on the deep circumflex iliac vessels.

Eight free iliac osteocutaneous flaps and three vascularized iliac bone grafts based on the deep circumflex iliac vessels were transferred in 11 cases of large skin and bone or bone defects. Seven of the eight osteocutaneous flaps took successfully. The eighth demonstrated partial necrosis. There was complete bone union in ten cases, and no union in one case as a result of persistent infection. Based on this experience, we concluded that free osteocutaneous flaps based on the deep circumflex iliac vessels have the following advantages over free osteocutaneous flaps based on the superficial circumflex iliac vessels: the pedicle is long (5 to 7 cm); the nutrient vessels are large (artery: 2.2 mm; vein: 2.5 mm); the anatomic course of the vessels is constant; and there is a large amount of bone available.

Adolescent↗
PubMed1981

Endoscopic and histopathological study on primary and secondary intestinal lymphangiectasia.

Jejunal endoscopy and histopathological study of biopsied specimens were performed to clarify states of jejunal mucosa and the mechanism of enteric protein loss in six patients with protein-losing enteropathy, including four patients with intestinal lymphangiectasia, one patient with constrictive pericarditis associated with dilated lymphatics of the intestine, and one patient with Budd-Chiari syndrome. Three cardinal endoscopic findings, scattered white spots, white villi, and chyle-like substances covering the mucosa, were demonstrated in protein-losing enteropathy. Scattered white spots indicated markedly dilated lymphatics in the stroma of the villi. White villi seemed to be due to fats including chylomicrons or fat droplets in the absorptive cells, interepithelial spaces, and/or stroma, even though the biopsies were obtained in the fasting state. Therefore, white villi suggest impaired transport of fats from intestinal epithelial cells to intestinal lymphatics. These three cardinal findings are thought to be characteristic for protein-losing enteropathy secondary to lymphatic disorders.

Adolescent↗
PubMed1981

A case of subacute hepatitis with reversible liver fibrosis.

Reversibility of hepatic fibrosis was demonstrated histologically in a case with subacute hepatitis. His first liver biopsy showed the transformation to liver cirrhosis. Gamma-globulin, TTT and ZTT gradually recovered to normal range, and serial second to fourth liver biopsy revealed the gradual decrease in newly formed fibrous tissues of the liver.

Adult↗