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Biomedical subjects

M Trautmann

Publications and source records attributed to M Trautmann.

At least 109 records · Page 6Linked to original sources
PubMed1986

Trophic effect of truncal vagotomy on the rat pancreas.

The trophic effect of truncal vagotomy was studied in rats. Three months after vagotomy and pyloroplasty pancreatic weight was significantly increased by 40% (p less than 0.001). Gastric stasis and consecutive distension of the stomach was observed in the majority of vagotomized animals despite pyloroplasty; the trophic effect of vagotomy on the pancreas was most pronounced in animals with severe stomach distension. Basal gastrin levels were increased after truncal vagotomy but did not correlate to gastric stasis and to the hypertrophy and hyperplasia of the exocrine pancreas. Basal pancreatic polypeptide hexapeptide levels were not altered after vagotomy. Morphometric studies on the endocrine pancreatic tissue showed that the relative volume density decreased due to the increase in exocrine tissue. However, the total islet cell mass remained constant. It is concluded that chronic truncal vagotomy has a trophic effect on the exocrine but not on the endocrine pancreas; additional factors besides gastrin seem to be responsible for this.

Animals↗
PubMed1986

Ciprofloxacin: a comparative evaluation of its bactericidal activity in human serum against four enterobacterial species.

Serum bactericidal titres following a 200 mg i.v. dose of ciprofloxacin were measured in healthy volunteers and compared with those achieved with standard doses of ceftazidime, piperacillin and gentamicin, given alone or in combination. Five strains of each of four enterobacterial species were included in the study. Bactericidal titres 1 h after infusion of ciprofloxacin exceeded 1:16 for Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris and Enterobacter cloacae. While ceftazidime produced higher peak bactericidal titres against the Enterobacteriaceae, piperacillin was less effective than ciprofloxacin against three of the four enterobacterial species tested. Among the combinations, only piperacillin/gentamicin showed synergistic activity against some strains. Studies of bacterial killing kinetics again confirmed the high bactericidal activity of ciprofloxacin for the Enterobacteriaceae. The combination of ciprofloxacin with gentamicin resulted in more rapid killing of some strains of Klebsiella pneumoniae and Proteus vulgaris.

Adult↗
PubMed1985

Listeria meningitis: report of ten recent cases and review of current therapeutic recommendations.

Ten cases of meningitis due to Listeria monocytogenes were admitted to three hospitals in Berlin between 1978 and 1983. One patient was a premature infant in whom meningitis was diagnosed as part of typical granulomatosis infantiseptica. Another presented with signs of brainstem encephalitis which was confirmed post mortem. Positive blood cultures were obtained from five of the patients. Two strains of listeria were resistant and one was only moderately sensitive to penicillin. The three most recently isolated strains were tested for sensitivity to the third generation cephalosporins. All were resistant to latamoxef, and two were resistant to cefotaxime. The implications of these findings for the empirical treatment of purulent meningitis are discussed.

Adult↗
PubMed1985

Influence of different immunoglobulin G preparations on phagocytosis of Pseudomonas aeruginosa by polymorphonuclear granulocytes.

Commercially available immunoglobulin products suitable for intravenous application in humans are made by enzymatic or chemical modification of the IgG molecule. In order to examine, to which extent in vitro biologic functions of the IgG molecule are preserved in such preparations, specific antipseudomonal IgG from the rabbit was modified according to some of these procedures. The opsonizing activity of the different IgG preparations was evaluated in an in vitro system measuring the phagocytosis of Pseudomonas aeruginosa by rabbit granulocytes. The results demonstrated that the product Fab/Fc, which is made by papain or plasmin degradation of the IgG molecule, was still able to enhance phagocytosis but not to activate complement. The smaller papain- or plasmin-derived fragments Fab and Fc had no opsonizing activity. The pepsin-derived product F(ab')2 which possesses a divalent antigen binding site but lacks the Fc part, only enhanced phagocytosis when complement concentrations of more than 20% were present in the phagocytic system. Since the F(ab')2 fragment is not able to interact with Fc receptors or to activate complement via the classical pathway, the phagocytosis-enhancing activity of this molecule must be attributed to alternative complement pathway activation. In contrast to the enzymatically derived IgG preparations, a newly developed S-sulphonated IgG product was as efficient as unmodified IgG both in Fc- and complement-mediated opsonization.

Animals↗
PubMed1985

[Current aspects of pseudomonas meningitis].

The article reports on the incidence, the conditions of occurrence, possibilities and successes of treatment with certain (combinations of) antibiotics, in dealing with cases of pseudomonas meningitis. The various possible substances used for treatment are discussed. Rates of penetration and CSF concentrations of azlocillin and cefsulodin are stated. Alternative possibilities for treatment are pointed out.

Aminoglycosides↗
PubMed1985

In vitro and in vivo activities of different immunoglobulin G preparations from the rabbit against Enterobacteriaceae.

Specific rabbit IgG, prepared against three enterobacterial strains, was modified according to procedures used for the production of human IgG preparations suitable for intravenous infusion. The resulting products were examined for their in vitro opsonic and in vivo protective activity against the respective bacterial strains. A sulfonated IgG preparation (S-sIgG) and the enzymatically derived fragments F(ab')2 and Fab/Fc were opsonic in vitro and provided in vivo protection against lethal enterobacterial infection in mice. Protection by Fab fragments varied in the different in vivo models.

Animals↗
PubMed1985

A study of the penetration of temocillin in the cerebrospinal fluid.

Temocillin concentrations in serum and cerebrospinal fluid (CSF) samples from 8 patients were assayed by high pressure liquid chromatography. It was possible to determine sequential series of ventricular (CSF) and serum concentrations in 4 adult neurosurgical patients with slight to moderate impairment of blood-CSF barriers, because serial CSF samples were obtained from external ventricular drains. In 4 other patients with meningitis, temocillin was given in addition to the regular treatment schedule and 6 'spot' concentrations of temocillin in lumbar CSF and serum samples were determined. Temocillin CSF concentrations in these subjects seemed to be inadequate for the treatment of Gram-positive bacterial meningitis and only partially valuable for the treatment of Gram-negative bacillary meningitis.

Adult↗
PubMed1985

[The effect of cefaclor, doxycycline and other oral antibiotics on phagocytosis of polymorphonuclear granulocytes and PHA-induced stimulation of blood lymphocytes in man].

The influence of the orally applicable antibacterial agents, cefaclor (Panoral), doxycycline, erythromycin, and cotrimoxazole on phagocytosis by human neutrophil granulocytes was investigated. Further, the influence of cefaclor, erythromycin, and doxycycline on PHA stimulation of human blood lymphocytes was studied. Doxycycline (1 mg/ml) had strongly suppressive effects on phagocytosis, whereas cefaclor (1 mg/ml cotrimoxazole (0.1 mg/ml), and erythromycin (0.1 mg/ml) did not suppress phagocytosis. PHA-induced lymphocyte stimulation was strongly inhibited by doxycycline (10 micrograms/ml), whereas cefaclor (10 micrograms/ml) did not suppress at all. Erythromycin (10 micrograms/ml) exerted some inhibition (average 12.6%). These results are discussed with respect to immunoneutrality of antibacterial agents.

Anti-Bacterial Agents↗
PubMed1984

[Therapeutic and opsonizing effect of specific antibacterial immunoglobulins in experimental Klebsiella septicemia in mice].

Intravenous infection of NMRI mice with a highly virulent strain of Klebsiella pneumoniae induced protracted septicemia with high lethality. Treatment of the animals with specific rabbit immunoglobulins was able to lower mortality significantly if the immunoglobulins were administered no later than 6 hours after infection. In cyclophosphamid-treated mice, even inocula as low as 10-20 organisms proved to be highly lethal. Immunoglobulins were similarly protective under these conditions and significantly lowered mortality even when injected as late as 8 hours after infection. When immunocompromised mice were infected with higher challenge inocula, the therapeutic effect decreased and the time interval allowing efficient therapy became shorter. However, even if immunoglobulin therapy was performed too late, it was able to delay mortality for several days.

Animals↗
PubMed1984

[Anaerobic bacterial meningitis with multiple brain abscesses].

The improvement of bacteriological techniques for isolation and identification of anaerobes has led to an increased interest in anaerobic infections. However, anaerobes have only rarely been found in cases of purulent meningitis, representing less than 1 percent of all isolated pathogens. We observed anaerobic meningitis in a patient suffering from multiple lung abscesses from which anaerobic bacteria spread to the brain, causing formation of anaerobic brain abscesses and consecutive meningitis. Microbiological examinations for anaerobes should be performed in those cases of meningitis in which purulent infections of other organs with known or suspected anaerobic etiology are present or in which a traumatic lesion of the subarachnoid space has preceded the development of meningitis.

Adult↗
PubMed1983

Netilmicin in human CSF after parenteral administration in patients with slightly and severely impaired blood CSF barrier.

After administration of 150 mg netilmicin samples of CSF and blood were obtained. In one group of nine patients with no or only slight impairment of the blood-CSF-barrier 29 samples of CSF were assayed for netilmicin concentrations. All samples, obtained after the first dose, failed to reveal detectable drug levels. Drug levels up to 0.18 mg/l were detected in samples of CSF of three patients after 3 to 22 doses. Only the lumbar CSF of one patient contained netilmicin concentrations higher than 1.0 mg/l. In comparison 19 samples of CSF, obtained from patients with meningitis after more than one dose of netilmicin, had levels of 0.27-5.0 mg/l. Three CSF samples from patients out of this group, collected after the first dose of netilmicin failed to show any drug activity.

Adult↗
PubMed1983

Focal tuberculous meningoencephalitis.

Tuberculous meningitis was diagnosed in a 16-year-old patient with symptoms and signs of a space-occupying process of the right hemisphere. Cranial computed tomography demonstrated focal encephalitis of the right temporoparietal region. The case reminds that tuberculous meningitis can present itself under uncommon neurologic syndromes and should, even in the presence of such unusual findings, be considered with a high index of suspicion.

Adolescent↗
PubMed1983

[Toxic shock syndrome].

The entity of the variable pictures of an illness summed up by the description "toxic shock syndrome" has been focussed on by a great number of publications in Northern America since 1978, but has been described scarcely until yet in Germany. An etiological relationship with formerly described "toxic scarlet fever" and "Kawasaki syndrome" is to be discussed. This case in charge deals with a 25-year-old female patient, who developed acutely without any former disease during her menstruation an illness of severe clinical presentation. The findings were high fever, arterial hypotension, and reversible renal failure, watery diarrhea and vomitus , different cutaneous manifestations and signs of disseminated intravascular coagulation, and severe thrombocytopenia with bleeding mucosal ulcerations. Massive growth of Staphylococcus aureus was demonstrable as well as growth of Proteus mirabilis and E. coli in a culture of vaginal smear.

Adult↗
PubMed1982

[Encephalitis due to listeria monocytogenes: a complication of immunosuppressive therapy (author's transl)].

Two cases of encephalitis due to Listeria monocytogenes with lethal outcome are presented. The infection occurred during immunosuppressive treatment for panarteritis nodosa and sarcoidosis, respectively. The pathological-anatomical findings were a diffuse purulent meningoencephalitis in the first case and a focal rhombencephalitis with necrotizing inflammation of brainstem and cerebellum in the second one. Listerial infections of the adult are gaining increasing importance as severe complications of immunosuppressive treatment.

Adrenal Cortex Hormones↗