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Infundibulocystic basal cell carcinoma.

We report on a 72-year-old male patient with a solitary, dome-shaped tumor on the preauricular region. Histologically, it showed an intradermal basaloid cell tumor composed of many anastomosing epithelial cords. There were multiple infundibular cystic structures containing corneocytes lined by follicular infundibular epithelium and bud-like structures simulating the follicular germs throughout the neoplasm. Follicular bulbs and papillae were absent within the tumor. The stroma was scant and not highly fibroplastic. The tumor was diagnosed as infundibulocystic basal cell carcinoma, a recently described, uncommon variant of basal cell carcinoma.

Aged↗

PubMedDate not supplied

Serum human hepatocyte growth factor (hHGF) is elevated in patients with metastatic gastric carcinoma.

BACKGROUND/AIMS: Hepatocyte growth factor (HGF) is a stromally derived protein growth factor that modulates epithelial cell proliferation and motility. HGF may therefore be involved in tumor progression. METHODOLOGY: We measured the immunoreactive (ir)-HGF concentration in the sera of 56 patients with human gastric carcinoma, using an enzyme-linked immunosorbent assay and evaluated its association with clinical and histopathologic factors. Clinical stages were classified in accordance with The General Rules for TNM Classification (International Union Against Cancer). RESULTS: The serum hHGF concentrations from patients with gastric carcinoma significantly increased with increasing pathologic tumor grades. Also, there were significantly higher concentrations in patients with nodal metastasis compared to patients without metastasis. The serum hHGF concentrations in patients with liver metastasis were significantly higher than in patients without liver metastasis. CONCLUSIONS: These data show that the serum hHGF concentration is elevated in gastric carcinoma patients with liver and nodal metastasis. In multivariate analysis, the serum hHGF concentration was found to be the most important independent factor in predicting overall survival. Thus, the current results suggest that HGF may be important in the progression and metastasis of gastric carcinoma.

Carcinoma↗