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Biomedical subjects

M Toga

Publications and source records attributed to M Toga.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Morphological and biochemical changes in muscle and peripheral nerve in Fabry's disease.

In a case of Fabry's disease, microscopic, ultrastructural, and biochemical studies of a muscle biopsy were performed, as well as microscopic, ultrastructural, and morphometric studies of a nerve biopsy. Pleomorphic lipid inclusions were observed in muscle fibers, fibroblasts, and endomysial capillaries. Moreover, the thermolabile isoenzyme A of alpha-D-galactosidase was almost completely absent. In the nerve specimen, polymorphous lysosomes were noted in perineural cells, in fibroblasts, and in endothelial and perithelial cells in association with some nonspecific degenerative changes. The morphometric data revealed a loss of large myelinated fibers, an uncommon finding in Fabry's disease, and a decrease of the average diameter of the unmyelinated fibers, which was related to axonal sprouting. The relationship between the pain attacks and the increased number of the small unmyelinated fibers is discussed.

Adult↗
PubMedDate not supplied

[Epilepsy in renal insufficiency and accidental epileptic seizures during hemodialysis (artificial kidney)].

The authors, referring to 29 observed cases, review the characteristics of true renal epilepsy with regard both to attacks and to interictal periods. Their research shows that this type of epilepsy cannot be explained by any specific anatomical lesion but is probably functional and more specifically metabolic; it disappears when renal dialysis is performed. The authors accept that the factors liable to provoke this kind of epilepsy include cellular hyperhydration possibly associated with hypocalcaemia and with a genetic predisposition to convulsions. They reject the role of uraemia. This type of renal epilepsy is compared to the epileptic attacks provoked by renal dialysis.

Cerebellar Cortex↗