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Biomedical subjects

M Toga

Publications and source records attributed to M Toga.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

[Ultrastructural study of a Masson's "humid meningioma"].

The authors report the ultrastructural analysis of a Masson's humic meningioma. The tumor presents at the electronic microscopic examination every sign of secretive hyperactivity and does not show any degenerative characteristics. The existence of an important extracellular material rich in pre-collagenic fibres accounts for lacunar texture of this neoplasia at optic microscopic investigation; the role played by tumoral cells in the elaboration of the material is taken into account and seems to corroborate histogenic ecto-mesenchymatous theory of arachnoidal cells.

Capillaries↗
PubMedDate not supplied

[Senile plaque].

Explore the source record for details and available documents.

Age Factors↗
PubMedDate not supplied

[Immunohistochemical detection of calcitonin, ACTH, beta-MSH, beta-endorphin and somatostatin in medullary carcinoma of the thyroid. Immunoperoxidase study (PAP, ABC) of 10 cases].

Ten cases of Medullary carcinoma of Thyroid gland (MCT) were examined (two familial, eight sporadic) in patients with increased serum calcitonin levels and ranging age from 31 to 87 years. Immunocytochemical reactions were performed using Peroxidase-Antiperoxidase (PAP) complex and/or Avidin-Biotin-Peroxidase complex (ABC) by light microscopy on fixed tumorous specimens (10 cases) and additionally by electron microscopy (3 cases). The tumors displayed light microscopic features typical of MCT. The cells were polyhedral, angular or fusiform and showed high affinity for Grimelius stain. Large deposits of amyloid were Congo red stained and disclosed a green birefringence in polarized light. In the familial cases sections of non-tumorous thyroid tissue showed C cell hyperplasia. Electron microscopic studies revealed intracytoplasmic secretory granules and amyloid fibrils. The immunoperoxidase technique demonstrated calcitonin in the tumor cells in all the cases, with a weaker staining than in para-and intra-follicular C cells of adjacent non tumorous tissue and than in C cells hyperplasia foci, when present. Immunoreactive tumor cells were also observed with anti SRIF in 4 cases, with anti-ACTH and anti-beta MSH in 3 cases, and with anti-beta endorphin in 2 cases. These results are discussed with a review of the literature.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Periodic paralysis. Histological, histochemical and ultrastructural studies in five cases (author's transl)].

Muscle changed found in five patients with periodic paralysis are described. Three patients had familial hypokaliemic paralysis, one had familial periodic paralysis with hyperkaliemia, and one had periodic attacks of muscular weakness with thyrotoxicosis. According to the stage in the clinical course at which biopsy was performed, several pathological patterns are described. Vacuolization was the main feature in the early stages of periodic paralysis. Later in the clinical course, tubular aggregates were the characteristic findings. In addition, degenerative changes of the muscle fibres were found in patient exhibiting a permanent myopathic condition. In thyrotoxic periodic paralysis, the longer the clinical course, the more severe the changes appeared to be. Possible mechanisms leading to such structural abnormalities remain in question.

Adolescent↗
PubMedDate not supplied

[Progressive multifocal leukoencephalopathy and hemochromatosis. Pathological study of a case (author's transl)].

A case of progressive multifocal leukoencephalopathy (P.M.L.) with humoral immunologic deficiency and hemochromatosis has been studied by light and electron microscopy. Widespread demyelination of white substance, gigantic astrocytes, inflammatory perivascular cuffs and numerous nuclear and cytoplasmic viral inclusions, suggesting Papovavirus were observed. The relationship between P.M.L. and hemochromatosis is discussed.

Adult↗