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Biomedical subjects

M Thompson

Publications and source records attributed to M Thompson.

At least 397 records · Page 22Linked to original sources
PubMed1975

A further example of the recessive Lu(a-b-) phenotype.

A family study is reported in which two members of the Lu(a-b-) type. A recessive mode of inheritance is postulated from the failure of the phenotype to occur in other generations and from consanguinity in the propositus' parents.

Adult↗
PubMed1975

Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen.

Doses of 600 mg and 1200 mg of D(-)penicillamine daily were superior to a standard regimen of therapy in rheumatoid arthritis. The higher dose did not produce significantly greater therapeutic benefit in the group of patients so treated, although individual patients sometimes improved more. The frequency of rashes, blood dyscrasias, and withdrawals from the trial increased withe dosage. It is concluded that D(-)penicillamine is a useful treatment that the daily dose should be as low as possible, and that it should be increased at infrequent intervals only, with due regard to the likelihood of further improvement in relation to an increased risk of adverse reactions.

Acetaminophen↗
PubMed1975

Induction of allergic encephalomyelitis using hydrosoluble adjuvant and the tryptophan region of myelin basic protein.

Experimental allergic encephalomyelitis has been induced in guinea pigs using the encephalitogenic tryptophan peptide as antigen and a hydrosoluble adjuvant extracted from Mycobacterium tuberculosis, var. hominis, strain H37Ra. The maximum response was observed using 100mug of adjuvant per animal. This is a quantity of adjuvant substantially higher than was necessary to induce disease utilizing the whole myelin basic protein as antigen.

Adjuvants, Immunologic↗
PubMed1974

Aspirin and analgesic nephropathy.

Renal function was studied in 17 patients with rheumatoid arthritis who had each consumed between 5 and 20 kg of aspirin. After an interval of two years 14 of these patients-seven of whom had consumed a further mean of 2 kg of aspirin-had their renal function retested. No relation was found between total dose, rate, or duration of ingestion and any aspect of renal function that was studied. All patients had plasma creatinine levels within the normal range, though slight depression in creatinine clearance was not uncommon.From this study and other published data we conclude that aspirin rarely if ever causes analgesic nephropathy when prescribed alone in doses appropriate to the treatment of rheumatoid arthritis.

Adult↗