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Biomedical subjects

M Thiery

Publications and source records attributed to M Thiery.

At least 253 records · Page 14Linked to original sources
PubMed1976

Placental transfer of thiamphenicol.

The placental transfer of thiamphenicol was studied in 29 subjects at term after intravenous bolus injection of 500 mg of the drug. Detectable plasma levels were present in umbilical blood and amniotic fluid as early as 5 and 18 minutes, respectively, after maternal administration. With the dosage applied, minimum concentrations required for the inhibition of many organisms causing intrauterine infections were reached in maternal and fetal plasma and in amniotic fluid. The value of thiamphenicol for the treatment of intrauterine infections is discussed.

Adult↗
PubMed1976

Uterine contractility in spontaneous and induced labour.

Contractility parameters (uterine activity, contraction interval, amplitude, and frequency of contractions) were analyzed quantitatively during the active phase of first-stage of labour in 60 clinically normal term nulliparae with spontaneous or induced labour. Inductions were surgical (amniotomy alone) or by amniotomy combined with either intravenous oxytocin or prostaglandin administered intravenously (PGF 2alpha or PGE 2) or orally (PGE 2).

Administration, Oral↗
PubMed1975

Prostaglandin E2 on the electroencephalogram.

Present study was prompted by the report from another center on the occasional occurrence of convulsions and abnormal electroencephalogram (E.E.G.) patterns in women aborted with intra-amniotic prostaglandin F2alpha (PGF2alpha). Fifty four subjects were investigated by means of an E.E.G. taken before and after initiation of PGE2 administration. They included pregnant and non-pregnant patients, nearly half (23) of whom were known epileptics. One seizure was observed during PG administration in a man with daily psychomotor attacks who had not taken his anticonvulsants on the day the test was performed. PGE2 caused no alteration of the E.E.G. in subjects with a normal control tracing; in those with an abnormal E.E.G., a deterioration was seen in one and an improvement in three. It is concluded that PGE2 is not epileptogenic at doses required for termination of pregnancy.

Abortion, Induced↗