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Biomedical subjects

M Tariq

Publications and source records attributed to M Tariq.

At least 127 records · Page 7Linked to original sources
PubMed1982

Effect of carbon tetrachloride on cardiac lipid peroxidation, serum lipids and enzymes of albino rats.

Carbon tetrachloride (CCl4) at the dose of 0.3 ml/100 g body weight i.p. induced changes after 18 h in the cardiac lipid-peroxidation, serum-free fatty acids (FFA), cholesterol, and enzymes in the rats. The cardiac lipid peroxidation and the activity of serum enzymes GOT and GPT were significantly increased. The levels of serum FFA and cholesterol were significantly decreased.

Alanine Transaminase↗
PubMed1980

Effect of phenelzine, a monoamine oxidase inhibitor, on isoproterenol-induced myocardial damage.

The effect of phenelzine on isoproterenol-induced myocardial necrosis was studied in rats. Male albino rats were pretreated with 20 mg/kg body wt of phenelzine, intraperitoneally, on 4 consecutive days. The same animals were given 80 mg/kg of isoproterenol subcutaneously on the third and fourth days of the study. After 48 hr of isoproterenol, ECG was recorded, the animals were killed, and blood, heart, and adrenal glands were removed for biochemical and histopathological studies. Phenelzine returned toward normal the isoproterenol-induced decreased in cardiac glycogen but decreased serum lactic acid only slightly toward normal. The serum enzymes, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), showed the protective effect of phenelzine. The increase in isoproterenol-induced free fatty acid (FFA) was significantly reduced in the group pretreated with phenelzine. Our studies on adrenal ascorbic acid suggest that the animals pretreated with phenelzine suffered less stress compared to the group treated with isoproterenol alone. Histopathological changes including focal areas of necrosis and characteristic cellular exudation were less marked in the hearts of rats pretreated with phenelzine. S-T segment elevation was more marked in the group treated with isoproterenol only.

Alanine Transaminase↗
PubMed1980

Biochemical and pathological changes in the heart following bile duct ligation.

Biochemical, histological, and ECG changes were studied on the second, fifth, tenth, and fifteenth days after bile duct ligation in male albino rats. The biochemical parameters included serum bilirubin, free fatty acids (FFA), serum glutamic oxaloacetic transaminase, pyruvate, serum bilirubin, free fatty acids (FFA), serum glutamic oxaloacetic transaminase, pyruvate, and cardiac glycogen. Maximum increase in serum bilirubin was noted on the 5th day after ligation. Although it decreased on the 10th and 15th days, the level on the 15th day was higher than in normal level. Serum enzymes, FFA, and pyruvate also showed a maximum level on the 5th day after ligation, with the levels returning toward normal on the 10th and 15th days. Maximum depletion of cardiac glycogen was observed on the 5th day, coming back toward normal on the 10th and 15th days. ECG studies showed bradycardia, increase in PR and QT intervals, and arrhythmia in a few cases. Histology showed cloudy swelling and accumulation of bilirubin in the myocardium with a maximum change on the 5th day. The significance of recovery after the 5th day is discussed.

Animals↗
PubMed1980

Effect of radiation on myocardial metabolism and structure.

The effects of gamma radiation on structure, function, and metabolism of rat heart were studied. The precordial region of male albino rats (weighing 150-200 g) was exposed to 4000, 6000, and 8000 rads of gamma rays, using a cesium-137. Seventy-two hours after exposure, ECG lead II was taken, and animals were killed. Blood, heart, and adrenals were collected for the study of serum lactic dehydrogenase (SLD), serum glutamic oxaloacetic transaminase (SGOT), serum lactate, cardiac glycogen, and adrenal ascorbic acid. Histopathology of the heart was done using eosine and hematoxyline stains. The structural, functional, and biochemical changes observed were directly proportional to the intensity of gamma radiation.

Adrenal Glands↗
PubMed1978

Levels of dopamine, norepinephrine and 5-hydroxytryptamine in different regions of the rat brain in thallium toxicosis.

The levels of dopamine, noradrenaline and 5-hydroxytryptamine were estimated in the hypothalamus and limbic areas, corpus striatum, cerebellum and the brain-stem of rats administered thallous acetate (5 mg/kg i.p.) daily for 7 days. Significant decreases in the concentration of dopamine occurred in the hypothalamus, limbic areas and corpus striatum. Noradrenaline did not reveal significant alteration in any of the regions of the brain examined. The concentration of 5-hydroxytryptamine was significantly lowered in the corpus striatum, cerebellum and the brain-stem.

Animals↗
PubMed1975

Myocardial metabolism at different environmental temperatures in experimental myocardial necrosis.

Although the effect of cold and heat stress on myocardial metabolisms has been widely studied, this parameter has not been investigated over a wide range of environmental temperatures after myocardial infarction. Since high as well as low temperatures are known to adversely affect the myocardium, changes in enviromental temperature are likely to be of great importance to patients suffering from acute coronary insult. Therefore, the myocardial metabolism was studied at different environmental temperatures in albino rats with isoproterenol-induced infarct-like myocardial necrosis. Male albino rats weighing 100 to 150 g were selected for the study. The investigations included ECG (lead II), histology, serum free fatty acids (FFA), serum triglycerides (TGS), cardiac noradrenaline, cardiac glycogen, and adrenal ascorbic acid, after the induction of myocardial necrosis. The biochemical changes were minimum between 10 and 15 degrees C while, at 4 degrees C, marked changes were observed. No significant change was seen in the serum triglycerides.

Adrenal Glands↗
PubMed1975

Effect of combination of stresses on myocardial metabolism.

The effect of hypoxia, exercise, and thermal stress on myocardial metabolism have been widely investigated, but little attention has been paid to studying the effects of a combination of these stress. The influence of hypoxia as modified by physical exertion (swimming) and cold stress was therefore studied. The parameters investigated included myocardial glycogen and noradrenaline, serum free fatty acid, adrenal ascorbic acid, and adrenal weight. It was observed that maximal stress was produced when hypoxia was combined with physical exertion. No suppression of cold-induced lipolysis by hypoxia was observed, in contrast to previously reported observations. Maximal depletion of cardiac blycogen and cardiac noradrenaline was noted in hypoxic exercise. Adrenal overactivity was not found to be related to any particular stress but was seen to be proportional to the severity of the stress applied.

Adrenal Glands↗
PubMed1975

Effect of conditioning on myocardial metabolism after myocardial infarction.

The present study was conducted to evaluate the effect of prior physical training on metabolic changes after isoproternol-induced myocardial infarction in albino rats. The evaluation was done in terms of serum transaminases (SGOT and SGPT), serum lactic dehydrogenase (LDH), serum creatine phosphokinase (CPK), cardiac glycogen, and cardiac noradrenaline. Male albino rats weighed 100-150 g were selected for the study. Physical training (conditioning) consisted in making the animals swim in a tank of water for 60 min daily on 6 days a week, for 8 weeks. Myocardial infarction was produced by subcutaneous injection of isoproterenol, 85 mg/kg body weight, on 2 consecutive days. There was significantly less elevation of SGOT, LDH and CPK in the conditioned group after myocardial infarction; the rise in SGPT was not significantly different in the two groups. A smaller rise of serum enzymes revealed less myocardial damage in the conditioned group; the rise in FFA was also less in the conditioned group, a more favorable situation for an ischemic myocardium. No significant difference was observed in cardiac glycogen and cardiac noradrenaline after isoproterenol-induced cardiac necrosis. The significance of these observations is discussed.

Alanine Transaminase↗