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Biomedical subjects

M Tariq

Publications and source records attributed to M Tariq.

At least 109 records · Page 6Linked to original sources
PubMed1986

Decrease by naloxone of some electrocardiographic and biochemical changes following endotoxin induced shock in rats.

Administration of endotoxin, a lipopolysaccharide extracted from cell walls of gram negative bacteria, elicited alterations in various metabolic parameters and in the electrocardiogram of rats. Cardiac glycogen and serum glucose were decreased, while serum pyruvate and acid phosphatase levels were increased. There was initial tachycardia followed by significant bradycardia and elevation of the ST segment in the animals with shock. Erythrocyte count, haemoglobin and haematocrit were not changed after shock. Treatment with naloxone caused significant decreases in the metabolic and electrocardiographic changes induced by endotoxin.

Acid Phosphatase↗
PubMed1986

Gastric antisecretory, gastric and duodenal anti-ulcer and cytoprotective properties of Ro 22-6923, a synthetic trimethyl prostanoid in rats.

Ro 22-6923, a synthetic trimethyl prostanoid, has been studied for its ability to inhibit gastric secretion and to protect the gastroduodenal mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, dimaprit, cysteamine and the cytodestructing agents--80% ethanol, 0.6 M HCl, 0.2 M NaOH, 25% NaCl, aspirin 30 mg in 0.35 M HCl and 100 mM sodium taurocholate in 0.2 M HCl. The results of this study demonstrate that Ro 22-6923 has both prophylactic and curative effects on various experimental models. It produces a dose dependent inhibition of the gastric mucosal damage induced by pyloric ligation, hypothermic restraint stress, NSAIDs, reserpine, dimaprit and cytodestructing agents and that of duodenal ulcers induced by cysteamine. It also produces a dose dependent healing of the acetic acid induced chronic gastric ulcers. These observations suggest that Ro 22-6923 exerts its anti-ulcer effects by its antisecretory, gastric mucosal resistance increasing and cytoprotective activities and that it may be a useful therapeutic agent for the treatment of peptic ulcer disease in humans.

Animals↗
PubMed1986

Effect of Cuscuta chinensis water extract on 7,12-dimethylbenz[a]anthracene-induced skin papillomas and carcinomas in mice.

Cuscuta chinensis, known as Aftimun, is reputed to have antitumour activity in the Unani system of medicine in India. The effect of a hot water extract of C. chinensis on 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin papillomas and carcinomas in Swiss albino mice was studied. Oral administration of the extract (1 g/kg body wt) thrice a week in 22 mice, started on the tenth day after the first application of DMBA to the 252nd day, markedly delayed the appearance and retarded the growth of papillomas and the incidence of carcinoma, relative to a control group with 28 mice, in a two-stage system of tumorigenesis. Its prophylactic effect was found to be statistically significant.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1986

Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity.

The effect of mastic, a concrete resinous exudate obtained from the stem of the tree Pistacia lentiscus, has been studied on experimentally-induced gastric and duodenal ulcers in rats. Mastic at an oral dose of 500 mg/kg produced a significant reduction in the intensity of gastric mucosal damage induced by pyloric ligation, aspirin, phenylbutazone, reserpine and restraint + cold stress. It produced a significant decrease of free acidity in 6-h pylorus-ligated rats and a marked cytoprotective effect against 50% ethanol in rats which could be reversed by prior treatment with indomethacin. The protective effect was not seen when it was given intraperitoneally in phenylbutazone and restraint + cold stress models. The reduction in the intensity of ulceration in cysteamine-induced duodenal ulcers was not found to be statistically significant in mastic-pretreated rats. The results suggest that mild antisecretory and a localized adaptive cytoprotectant action may be responsible for its anti-ulcer activity. These observations support the results of an earlier study on the clinical effectiveness of mastic in the therapy of duodenal ulcer.

Animals↗
PubMed1986

Evaluation of genotoxic potential of khat (Catha edulis) in Swiss albino mice.

Genotoxicity of the methanolic extract of khat (Catha edulis) has been evaluated on the male germ cells using the dominant lethal assay procedure in Swiss albino mice. The extract was administered at a dose of 500 mg/kg orally once daily, for five days. Following this sub-acute dose regimen, the effect of khat was studied during the different stages of spermatogenic cycle on the rate of pregnancy and post-implantation losses. Khat reduced the percent pregnancy rates and increased the mean post-implantation losses in the treated group. The increase was found to be statistically significant in the post-meiotic stages.

Animals↗
PubMed1986

The antidiabetic activity of aloes: preliminary clinical and experimental observations.

The dried sap of the aloe plant (aloes) is one of several traditional remedies used for diabetes in the Arabian peninsula. Its ability to lower the blood glucose was studied in 5 patients with non-insulin-dependent diabetes and in Swiss albino mice made diabetic using alloxan. During the ingestion of aloes, half a teaspoonful daily for 4-14 weeks, the fasting serum glucose level fell in every patient from a mean of 273 +/- 25 (SE) to 151 +/- 23 mg/dl (p less than 0.05) with no change in body weight. In normal mice, both glibenclamide (10 mg/kg twice daily) and aloes (500 mg/kg twice daily) induced hypoglycaemia after 5 days, 71 +/- 6.2 and 91 +/- 7.6 mg/dl, respectively, versus 130 +/- 7 mg/dl in control animals (p less than 0.01); only glibenclamide was effective after 3 days. In the diabetic mice, fasting plasma glucose was significantly reduced by glibenclamide and aloes after 3 days. Thereafter only aloes was effective and by day 7 the plasma glucose was 394 +/- 22.0 versus 646 +/- 35.9 mg/dl, in the controls and 726 +/- 30.9 mg/dl in the glibenclamide treated group (p less than 0.01). We conclude that aloes contains a hypoglycaemic agent which lowers the blood glucose by as yet unknown mechanisms.

Aloe↗
PubMed1986

Some central effects of indenolol in experimental animals.

Indenolol, a relatively new beta-adrenergic blocking drug, was tested for its effect on the central nervous system. The parameters included its effects on spontaneous motor activity, conditioned avoidance response (CAR) acquisition, pentobarbitone hypnosis, amphetamine induced motor excitation, analgesic activity and rectal temperature in experimental animals. Indenolol was found to significantly decrease the spontaneous motor activity in mice and CAR acquisition in rats. It potentiated the pentobarbitone induced hypnosis and antagonized amphetamine induced excitatory behaviour in mice. It did not show a marked analgesic effect of its own but potentiated the analgesia induced by the subanalgesic dose of morphine. It also produced a significant hypothermic effect in mice. All the effects except on CAR acquisition were obtained in the dose of 50-75 mg/kg body weight administered intraperitoneally. It enhanced CAR acquisition in the specific dose of 5 mg/kg. These observations indicate that indenolol possesses an anxiolytic effect similar to that reported for propranolol and some other beta-blocking drugs.

Adrenergic beta-Antagonists↗
PubMed1986

Effect of domperidone on experimentally induced gastric ulcers in rats.

The effect of domperidone, a peripheral dopamine receptor antagonist, has been studied in the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats. The gastric anti-ulcer activity of domperidone was evident following a single dose as well as a 5-day pretreatment against all the three ulcerogenic drugs. However, the protection in the five-day pretreatment group was greater than in the single dose pretreatment group. It appears that the gastrokinetic properties of domperidone play a significant role in producing this anti-ulcer effect. The study substantiates the results of the clinical observations on the healing of gastric ulcers and provides a rationale for further clinical studies in that direction. The possible mechanisms of action of this agent are discussed.

Animals↗
PubMed1985

Effect of nicotine and caffeine pretreatment on the gastric mucosal damage induced by aspirin, phenylbutazone, and reserpine in rats.

The effect of nicotine and caffeine pretreatment by feeding nicotine (2.5 mg %), caffeine (30 mg % base), and their combination (nicotine 2.5 mg % + caffeine 30 mg %) in drinking water ad libitum for 21 days was studied on the gastric mucosal damage induced by aspirin, phenylbutazone, and reserpine in rats. When given alone, neither nicotine nor caffeine produced any visibly discernible gastric lesions. Their concurrent administration too, did not produce any gastric mucosal injury. Pretreatment with nicotine, caffeine, and their combination resulted in significant augmentation of gastric ulcers produced by aspirin, phenylbutazone, and reserpine. However, caffeine administration produced a comparatively less profound augmentation of experimentally induced gastric lesions than that produced by nicotine pretreatment. The enhancement of gastric ulcers in the groups pretreated with the combination of nicotine and caffeine followed by one of the drugs was significantly greater than in the groups treated by either of them alone. The effect of nicotine on the mucus neck cell population of the gastric mucosa and on pancreatic bicarbonate secretion and the gastric secretory effect of caffeine may be responsible for the potentiation of the ulcerogenic effects of aspirin, phenylbutazone, and reserpine.

Administration, Oral↗
PubMed1985

Effect of nicotine, alcohol and caffeine pretreatment on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine in rats.

The effects of nicotine (2.5 mg/100 ml), alcohol (25% v/v) and caffeine (30 mg/100 ml base) and their combination (nicotine, 2.5 mg/100 ml; alcohol, 25% v/v; and caffeine, 30 mg/100 ml base) fed in drinking water ad libitum for 21 days were studied on the gastric mucosal damage induced by aspirin, phenylbutazone and reserpine in rats. When given alone, none of them produced any visibly discernible gastric lesions. Their concurrent administration, however, produced some injury to the gastric mucosa which was far less severe than the lesions induced by any of the ulcerogenic drugs used in this study. Pretreatment with nicotine, alcohol and caffeine and their combination resulted in a significant augmentation of gastric lesions produced by aspirin, phenylbutazone and reserpine. These results establish an association between nicotine, alcohol and caffeine in the pathogenesis of gastric ulcers and also implicate them as modifying factors in the genesis of gastric lesions induced by aspirin, phenylbutazone and reserpine.

Animals↗
PubMed1985

Pharmacological studies on Salvia haematodes Wall.

The aqueous extract of the root of Salvia haematodes has been investigated for its pharmacological actions on the cardiovascular and central nervous system. It was found to possess significant cardiotonic and anticonvulsant activities. It was not found toxic up to the dose of 5 g/kg given orally in order to evaluate its acute toxicity.

Animals↗
PubMed1984

Effect of bromocriptine, a dopamine receptor agonist, on the experimentally induced gastric ulcers in albino rats.

The effect of bromocriptine, a dopamine receptor agonist, has been studied on the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats. A single dose of bromocriptine 4 mg/kg s.c. produced a significant exacerbation of gastric ulcers induced by all the three ulcerogenic drugs, whereas in the same dose administered once daily for 5 consecutive days, it produced a marked protective effect in all the models. A review of the literature shows that different mechanisms may be involved in the opposite effects of acutely and chronically administered bromocriptine observed in this study. The study also points towards a role of dopamine in the pathogenesis of gastroduodenal ulceration.

Animals↗
PubMed1984

The effect of nicotine pretreatment on the gastric mucosal damage induced by aspirin and reserpine in rats.

The effect of nicotine pretreatment by feeding nicotine (5mcg/ml) in drinking water ad libitum for 10 days was studied on the aspirin and reserpine induced gastric mucosal damage in rats. The administration of nicotine resulted in the significant augmentation of aspirin (P less than 0.01) and reserpine (P less than 0.05) induced gastric ulcers. The mechanism(s) involving the sensitization of gastric mucosa towards the ulcerogenic effect of aspirin and reserpine may be responsible for the increased intensity of gastric ulcers in both the groups. The study indicates the possibility of a similar interaction in heavy smokers who ingest these drugs.

Animals↗
PubMed1984

Effect of sucralfate on the bioavailability of indenolol.

Effect of concurrent administration of sucralfate on the bioavailability of indenolol in rats has been investigated. Albino rats were administered with lg/kg body weight of sucralfate just before the oral administration of indenolol solution (10 mg/kg), blood samples were collected at 0,15,30,45,60,120,240 and 360 minutes after the administration of drugs. Indenolol concentration was determined spectrofluorometrically, 2,4, and 6-hour Area Under the Curve (AUC) was calculated. The peak indenolol blood concentration was observed at 45th minute of drug administration. The level in rats treated with indenolol alone (2.46 +/- 0.07 microgram/ml) and indenolol along with sucralfate (1.21 +/- 0.06 microgram/ml) suggested more than a 50% decrease. There were 36.4%, 27.2% and 20.4% decrease in 2-hour AUC, 4-hour AUC and 6-hour AUC respectively. The data suggest that sucralfate significantly decreased the absorption of indenolol, especially in the early phase after administration and clinically significant interaction may occur due to concurrent administration of indenolol with sucralfate.

Adrenergic beta-Antagonists↗
PubMed1983

Effects of propranolol and hydrocortisone pretreatment on radiation-induced myocardial injury in rats.

Earlier studies in our laboratory (23) showed evidence of dose-related acute injury to the myocardium after exposure of rats to ionizing radiation. Biochemical, histological, and electrocardiographic parameters were studied. In further continuation of this study, the effects of intervention by pretreatment with propranolol (10 mg/kg body weight) and hydrocortisone (10 mg/kg body weight) have been studied. The above drugs were administered to male albino rats weighing 150 to 200 g 30 min before exposure to 6000-rad single-dose gamma radiation over the precordial area. The parameters observed were cardiac glycogen, serum enzymes, lactate, pyruvate, blood sugar, adrenal ascorbic acid, and histology of the myocardium. The beneficial effects of this procedure are discussed.

Animals↗
PubMed1983

Effect of magnesium trisilicate and kaolin-pectin on the bioavailability of trimethoprim.

Variability in the bioavailability of orally administered trimethoprim due to Magnesium trisilicate and Kaolin-pectin has been investigated. The concentration of trimethoprim in blood was determined spectrofluorometrically at 0, 15 and 30 minutes and 1, 2, 4 and 6 hours. The area under the blood concentration curve of trimothoprim was significantly decreased, when the drug was given concurrently with magnesium trisilicate or kaolin-pectin. The mean decrease in maximum blood concentration of trimethoprim in magnesium trisilicate and kaolin-pectin treated groups was 49.94% and 29.42% respectively. The data suggest that a clinically significant interaction may occur due to concurrent administration of trimethoprim with these drugs.

Animals↗