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Biomedical subjects

M Tardieu

Publications and source records attributed to M Tardieu.

At least 181 records · Page 10Linked to original sources
PubMed1981

Progressive expanding congenital porencephalies: a treatable cause of progressive encephalopathy.

In congenital porencephalies, diverticulation of the lateral ventricle is a dynamic process producing compression and stretching of the brain tissue bordering the diverticulum, bulging of the overlying skull, macrocephaly, and occasionally progessive neurologic signs (hemiplegia, raised intracranial pressure), even when the rest of the ventricular system is not dilated and the CSF pressure is normal. Ventriculoperitoneal shunting can result in remarkable improvement of focal motor deficits and may apparently also play a beneficial role on further mental development. Successive computed tomography scans demonstrate that the brain parenchyma, which had been stretched by the porencephalic pouch, is capable of regaining near normal thickness. Congenital porencephalies are initiated by a limited destructive brain lesion, but the gradual expansion of the ventricular herniation may imply a mechanism identical to that which has been postulated in normal pressure hydrocephalus. Nine cases of unilateral "expanding" congenital porencephalies are presented and the treatment of this condition is discussed.

Brain↗
PubMed1980

Circulating immune complexes containing rubella antigens in late-onset rubella syndrome.

Eight infants with late-onset rubella syndrome were investigated. All patients had been infected by rubella virus during gestation but had minimal clinical symptoms at birth and during a latent period of several months. They presented secondarily an acute phase characterized by a severe multisystem disease. Antirubella antibody titers were present at low levels before and during the first weeks of the acute phase, contrasting with high serum levels of IgM. The percentage of T lymphocytes was very low and an increase of B lymphocytes was observed. The presence of circulating immune complexes which appeared to contain rubella antigens was demonstrated. These findings suggest that the lesions observed in late-onset rubella syndrome are partly due to CIC, and that suscepibility to infection can be related to a peripheral T and B lymphocyte disequilibrium.

Antigen-Antibody Complex↗
PubMed1980

Neonatal susceptibility to MHV3 infection in mice. II. Role of natural effector marrow cells in transfer of resistance.

Protection of newborn mice against MHV3 infection requires the transfer of several cell populations originating from adult syngeneic donors: adherent spleen cells, T lymphocytes, and a third population present in the nonadherent spleen cell fraction, in peritoneal exudates, and in bone marrow cells (M cells). M cells were found to be sensitive to short-term incubation at 37 degrees C and to preincubation with anti-bone marrow antiserum, mitomycin C, puromycin, and aggregated Ig, the latter suggesting the presence of Fc receptors. They were resistant to silica particles but were sensitive to irradiation with x-rays as well as with 89Strontium. Nonadherent spleen cells, however, behaved differently from M cells toward x-irradiation since they were radio-resistant, suggesting that M cells are precursors that require further differentiation or division to participate in MHV3 resistance. Effector M cells responsible for MHV3 resistance display, therefore, some similarities with natural killing cells. They might belong to a group of effector cells operative in regulatory processes or anti-tumor surveillance but also may be defense mechanisms against infectious diseases.

Aging↗
PubMed1980

[Persistence of herpetic inflammation of the central nervous system four years after an episode of acute encephalitis (author's transl)].

A patient was followed up for four years after an acute episode of encephalitis attributed to herpes because of the clinical and EEG features, the high serum antiherpetic antibody titers, the temporofrontal site of the lesions as shown by CT Scan. The clinical sequelae were non evolutive and the serum antiherpetic antibody titers remained at the same level (1/128) from the 10th day on. The CSF showed continuing pleiocytosis and slight elevation of protein with an increased proportion of IgG; moreover, four years later, the CSF antiherpetic antibody titers were elevated (1/16). These findings suggest that local production of antibody within the CNS may persist after acute herpetic infection.

Antibodies, Viral↗
PubMed1977

[Insulin-dependent diabetes associated with celisc disease in two families].

Two families in which insulin-dependent diabetes was associated with coeliac disease were studied. All patients had the HLA B 8 antigens. In one case there was an association of HLA B 8 with BW 15. The HLA B 8 determinant was found in that of the parents with a familial diabetic trait. These findings contribute to replace the association diabetes-coeliac disease in the larger frame of auto-immune diseases.

Adolescent↗
PubMed1975

[Immunological activities of rat lymphocytes. III. --Isolation of differing subpopulations of lymphocytes by two techniques of T cell separation].

In previous studies we have isolated by density gradient separation a population of relatively dense T lymphocytes capable of inhibiting the mitogenic response to concanavalin A (ConA) and phytohaemagglutinin. In this study we compared two current methods of cell separation for their relative yield in T lymphocytes able or not to respond to Con A. The present results show that cells passed through nylon wool columns--in contrast to those obtained by removal of lymphocytes which bind erythrocyte-antibody-complement complex-partially lose their ability to respond to ConA. The response lost by passage through nylon wool columns can be restored by centrifugation of the T cell suspension on a gradient of "Ficoll-Hypaque". This suggests that methods of T cells purification using density gradient separation may remove the more dense suppressor cells.

Animals↗