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Biomedical subjects

M Takeda

Publications and source records attributed to M Takeda.

At least 991 records · Page 55Linked to original sources
PubMed1982

Monoamines of taste buds in the fungiform and foliate papillae of the mouse.

After administration of monoamine precursors, taste buds in the fungiform and foliate papillae of the mouse were observed by means of electron microscopy and fluorescence histochemistry. The taste buds in the fungiform papillae differed in the ultrastructure of their apical regions from those in the foliate papillae, which contained the same taste buds as those described in the circumvallate papillae. The gustatory cells in both the fungiform and foliate papillae were capable of taking up monoamine precursors, although this ability was greater in the latter papillae. The results suggest that, not only in the circumvallate papillae but also in both the foliate and fungiform papillae, monoamines might be involved in neurotransmission from the gustatory cells to the nerves.

Amines↗
PubMed1982

Effect of a new potent H2-blocker, 3-]]]2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs.

The inhibitory effect of a new H2-receptor antagonist YM-11170 on gastric acid response to histamine and food was compared with that of cimetidine in the conscious dog with a Heidenhain pouch. When given intravenously at a steady state of gastric secretion by continuous infusion of histamine. YM-11170 was 42 times more potent and 1.3 times longer-lasting (p less than 0.05) than cimetidine in reducing the total acid output. The higher potency of YM-11170 than that of cimetidine was also demonstrated in oral antisecretory tests with histamine. The oral ED50 relative to i.v. ED50 as an indirect indication of absorption rate of the drugs was 2.9 for YM-11170 and 2.7 for cimetidine. The secretory response to food stimulation was also antagonized by oral administration of YM-11170 with 40 times greater potency than that of cimetidine. The antisecretory effects of the drugs on the histamine-induced gastric secretion were characterized by a marked decrease in the secretory volume. No behavioral change was observed in association with the H2-blockers. These results indicate that YM-11170 is a very potent inhibitor of gastric acid secretion and also suggest that the absorption rate of YM-11170 from the gastro-intestinal tract is similar to that of cimetidine.

Animals↗
PubMed1982

Effect of a new potent H2-blocker, 3-[[[2-(diaminomethylene)amino]-4-thiazolyl]methyl]thio]-N2-sulfamoyl propionamidine (YM-11170), on gastric secretion, ulcer formation and weight of male accessory sex organs in rats.

A new H2-blocker, 3-[[[2-[(diaminoethylene)amino]-4-thiazolyl]ethyl]thio]-N2-sulfamoyl propionamidine (YM 11170) inhibited gastric secretion of both acid and pepsin, when given intraduodenally to pylorus-ligated rats. The effectiveness of YM-11170 in the inhibition of acid output was 50 times as potent as that of cimetidine. The higher antisecretory activity of YM-11170 than that of 1-cyano-2-methyl-3-[2-[[(5-methylimidazol-4-yl)-methyl]thio]ethyl]guanidine (cimetidine) was also demonstrated by oral or i.v. administration. The development of gastric ulcer induced by either indometacin or acetylsalicylic acid in rats was markedly suppressed by YM-11170 with higher potency than by cimetidine. In castrated and androgenized rats, the decrease in the seminal vesicle and ventral prostate weights was not observed after treatment with YM-11170. These results suggest that YM-11170 is a potent antisecretory agent without antiandrogenic activity.

Androgen Antagonists↗
PubMed1982

Metastasis of renal sarcoma.

Data from 27 autopsy cases of renal sarcoma were investigated concerning the mode of metastases. The incidence was 1% in 2,651 cases of new growths of the kidney. Histologically nine were leiomyosarcoma, and five each were rhabdomyosarcoma and fibrosarcoma. The lungs, lymph nodes and liver were the most frequent sites of metastases. No significant differences in metastatic sites were noted among the histological types. Two cases or 7% had no metastasis and this percentage is comparable to that for other new growths of the kidney.

Adult↗
PubMed1981

Glucose-induced inactivation of mitochondrial enzymes in the yeast Saccharomyces cerevisiae.

1. Addition of glucose induced an inactivation of mitochondrial enzymes in the yeast Saccharomyces cerevisiae containing normal mitochondrial particles. 2. The glucose-induced inactivation of mitochondrial enzymes was inhibited by the presence of cycloheximide. 3. Pepstatin also inhibited the inactivation, but phenylmethanesulphonyl fluoride accelerated the inactivation. 4. The specific activities of fructose 1,6-bisphosphatase and cytoplasmic malate dehydrogenase were decreased on the exposure to glucose, as well as those of the mitochondrial enzymes. However, the glucose-induced inactivation of cytoplasmic enzymes was not inhibited by the presence of pepstatin. 5. The specific activities of hexokinase and phosphofructokinase, which are cytoplasmic enzymes were increased by the addition of glucose, and this effect was not affected by pepstatin. 6. Addition of glucose resulted in an increase in the synthesis of proteins of the mitochondria and the cytosol, and simultaneously in degradation of these mitochondrial and cytoplasmic proteins.

Cycloheximide↗