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Biomedical subjects

M Takada

Publications and source records attributed to M Takada.

At least 649 records · Page 36Linked to original sources
PubMed1985

[Familial occurrence of intracranial arteriovenous malformation].

It is beyond that cerebral arteriovenous malformation (AVM) is a congenital disease based on abnormal vascular formation in the embryonic stage. Nevertheless, familial occurrence of cerebral AVMs has been previously reported only in five families throughout the world, when complications of specific diseases such as Sturge-Weber-Dimitri disease, von Hippel-Lindaeu disease, and Osler-Rendu-Weber disease were ruled out. We have recently encountered four cases of two familial AVMs. In this paper, we review nineteen cases of nine familial AVMs from literature including our four cases from two families. Case 1: A 50-year-old male was admitted in June, 1975, for clonic convulsion. Cerebral angiography showed an AVM situated in the left parietal region, which was supplied from callosomarginal and central arteries. Total excision of the AVM was performed. The patient was completely cured and discharged without abnormal neurological deficits. Case 2: A 16-year-old male was admitted in May, 1978, with about ten years history of general convulsions. This patient was the third child of Case 1. Cerebral angiography revealed an AVM situated in the right parietal region, which was supplied from callosomarginal and precentral arteries. Total resection of the AVM was performed. The patient was completely cured. Case 3: An 11-year-old boy was admitted to our hospital in a comatose state in January, 1978, and soon died. Cerebral angiography showed only presence of internal hydrocephalus. The autopsy revealed a hematoma in the right cerebellar hemisphere with bilateral intraventricular hematomas, and AVM was histologically found in the cerebellum.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Response and pharmacokinetics of cisplatin instilled into the pleural cavity].

The response and pharmacokinetics of cisplatin instilled into the pleural cavity were studied in 11 patients with malignant pleural effusion; 10 patients had primary lung cancer and one had breast cancer. All of them were adenocarcinoma histologically. In five of the 11 patients effusion disappeared and its cytology became negative for malignancy after four weeks. In the other six patients effusion was reduced and its cytology became negative for malignancy after four weeks. Toxicity was almost similar to that in systemic administration of cisplatin but a few patients had chest pain and fever possibly due to local irritation. The pharmacokinetics showed that a high concentration of cisplatin (free-form, 48.9 micrograms/ml) was maintained over a long period (free from (t 1/2) beta = 33.6 hours) in the pleural cavity. This was regarded as the reason for the high response to this therapy. The intrapleural instillation of cisplatin into the pleural cavity therefore seems to be an effective modality for malignant pleural effusion.

Aged↗
PubMed1984

An anterograde-retrograde transneuronal transport of conjugates of wheat germ agglutinin with horseradish peroxidase (WGA-HRP): labeling of neurons in the reticular nucleus of the thalamus with WGA-HRP injected into the posterior column nuclei in the cat.

Neuronal cell bodies in the reticular thalamic nucleus (R) were labeled with wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) which was injected contralaterally into the posterior column nuclei (PCN) in the cat. The tracer was assumed to be transported to the posterolateral ventral thalamic nucleus (VPL), where it could escape from axon terminals of the PCN neurons and then be taken up by axon terminals of R neurons to label retrogradely the cell bodies of the R neurons.

Animals↗
PubMed1984

Increased lung uptake of liposomes coated with polysaccharides.

Liposomes labeled with [14C]coenzyme Q10 in the lipid bilayer were coated with various polysaccharide derivatives, i.e., palmitoyl conjugates of pullulan, pullulan phosphate, amylopectin, amylopectin phosphate and amylopectin sulfate. The kinetics of disposition and the tissue distribution of [14C]coenzyme Q10 after intravenous injection of the liposomes into guinea pigs were investigated. Lung uptake of radioactivity after injection of the O-palmitoyl amylopectin- and O-palmitoyl amylopectin phosphate-coated liposomes was 5- and 3-times higher, respectively, at 30 min after injection than that of the conventional liposomes. For doubly labeled liposomes with [3H]inulin and [14C]coenzyme Q10, the 3H/14C ratios in the lung, spleen and heart were similar to one another. Urinary excretion of [3H]inulin encapsulated in O-palmitoyl amylopectin-coated liposomes was much lower than that of unencapsulated [3H]inulin. These observations suggest that the O-palmitoyl amylopectin-coated liposomes are rather stable in vivo and are taken up into tissues in the intact form.

Animals↗
PubMed1984

Distribution of premotor neurons for the hypoglossal nucleus in the cat.

After injecting horseradish peroxidase into the hypoglossal nucleus, labeled neuronal cell bodies were constantly seen bilaterally with a slight ipsilateral dominance in the parvocellular reticular formation and reticular regions around the hypoglossal nucleus, ipsilaterally in the nucleus of Kölliker-Fuse, and contralaterally within the hypoglossal nucleus. A few labeled neurons were often found bilaterally with an ipsilateral dominance in the inter- and supratrigeminal regions around the motor trigeminal nucleus, parabrachial nucleus, ventral portions of the medial reticular formation of the pons and medulla oblongata, and dorsal tegmental regions and central gray of the midbrain.

Animals↗
PubMed1984

Distribution of premotor neurons for orbicularis oculi motoneurons in the cat, with particular reference to possible pathways for blink reflex.

After injecting horseradish peroxidase into the facial nucleus regions containing orbicularis oculi motoneurons, labeled neuronal cell bodies were found in the lateral medullary reticular formation, pretectal olivary nucleus, sensory trigeminal nuclei, lateral and medial parabrachial nuclei, ventromedial reticular formation medial to the facial nucleus, red nucleus and its surroundings, anterior horn of the upper cervical cord, medullary raphe nuclei, oculomotor nucleus and its surroundings, nuclei of Darkschewitsch, Cajal and Edinger-Westphal, ventral part of the midbrain central gray, pontine tegmentum, lateral vestibular nucleus and deep layers of the superior colliculus.

Animals↗
PubMed1984

Trigeminal primary afferent neurons projecting directly to the solitary nucleus in the cat: a transganglionic and retrograde horseradish peroxidase study.

After applying horseradish peroxidase to peripheral branches of the trigeminal nerve in the cat, the lingual and pterygopalatine nerves were found to contain fibers which ended ipsilaterally in the rostral portions of the solitary nucleus (SN); massively in the medial and ventrolateral SN, moderately in the intermediate and interstitial SN and sparsely in the ventral SN. The rostralmost part of the SN was free from labeled terminals. After injecting the enzyme into the SN portions rostral to the area postrema, small neurons were scattered in the maxillary and mandibular divisions of the trigeminal ganglion.

Animals↗
PubMed1984

Direct projections from the substantia nigra to the posterior thalamic regions in the cat.

The substantia nigra (SN) of the cat was shown, by the anterograde and retrograde horseradish peroxidase methods, to contain neurons which send their axons to the caudomedial portions of the suprageniculate nucleus and/or lateroposterior nucleus of the thalamus; these neurons were located in the restricted region in the lateral part of the SN, which corresponds to the pars lateralis of the SN.

Afferent Pathways↗
PubMed1984

Esophago-pleuro-cutaneous fistula. A case report.

In a sixty-three year old Japanese man with a history of long standing pulmonary tuberculosis, an unusual esophago-cutaneous fistula developed. The possibility of esophago-pleuro-cutaneous fistula was considered, because there was an old tuberculosis causing lung abscess of hilar lymph node adenopathy and which facilitated development of an extensive fistulous tract. The patient was effectively treated by palliative surgical procedure. This may be the first report of a benign esophago-pleuro-cutaneous fistula.

Esophageal Fistula↗
PubMed1984

Divergent effects of prolactin on 4-ene-5 alpha-reductase activity and production of C19-steroids from progesterone in immature rat ovary.

Female rats of the Sprague-Dawley strain were used. Two pituitaries from 9-week old rats were grafted in both kidneys of 21-day old rat to induce hyperprolactinemia. All rats with or without pituitary isografts were hypophysectomized on day 26. Starting from day 29, the rats in groups of 8-11 were injected daily with 5 micrograms NIH-LH-S19 or saline for 3 days. Ovarian homogenates from these rats on day 32 were incubated with [14C]4-androstene-3,17-dione or [3H]progesterone and steroid metabolism was estimated. In the hypophysectomized rat ovary, the 5 alpha-reductase activity was stimulated significantly by LH. Although pituitary isograft alone had no stimulative effect on 5 alpha-reductase activity of the hypophysectomized rat ovary, concomitant treatment with LH and pituitary isograft (prolactin) had an additive effect. Formation of the sum of C19-steroids from progesterone in the hypophysectomized rat ovary was stimulated markedly by LH but reduced slightly by prolactin. The LH-induced production of C19-steroids from progesterone was inhibited markedly by prolactin. These results indicate that prolactin treatment inhibits basal and LH-induced production of C19-steroids from progesterone but stimulates LH-induced 4-ene-5 alpha-reductase activity in immature rat ovary.

Androgens↗
PubMed1984

A case of hereditary elliptocytosis associated with constitutional indocyanine green excretory defect.

A 24-year-old woman was diagnosed as having hereditary elliptocytosis and post-transfusion hepatitis. On admission, a marked delay in indocyanine green (ICG) plasma clearance was noted while bromsulphalein excretion was almost normal. Even when her levels of serum bilirubin and transaminases were decreased to the normal ranges and a liver biopsy revealed no evidence of any liver cirrhosis or active hepatitis, ICG excretion still remained abnormal. These findings were compatible to those of constitutional ICG excretory defect.

Adult↗
PubMed1984

[A case of intracranial multiple fibrous histiocytoma. Case report and review of literature].

A case of intracranial multiple fibrous histiocytom is arising from the dura mater and both lateral ventricles is presented. To the authors' knowledge, this is the ninth case of intracranial fibrous histiocytomas reported in the literature. A 10-year-old girl was admitted with a 6 month history of cerebellar ataxia. Radiological examination including CT scan revealed a large mass in occipito-suboccipital region. On November 1, 1978, subtotal resection of the tumor was performed. Yellowish hard tumor, weighing 195 g had wide attachment to the dura mater, but did not invade the brain tissue. Postoperative CT scan, three months later revealed the other tumors in the left lateral ventricle and in the suprasellar region in addition to the lesion that had been operated on. In the course of hospitalization, the suprasellar tumor enlarged rapidly despite of 60Co radiation therapy, then led her to hypothalamic dysfunction. In January, 1981, she had paraplegia and paresis of the right upper extremity. Spinal lesion at the level of C-5 was presumed, but further examination was not performed because of her poor condition. On February 19, 1981, she expired. Autopsy of the head revealed four independent lesions in both lateral ventricles, the suprasellar region and the residual lesion which had been resected subtotally at the operation, respectively. Entire falx cerebri was invaded continuously by the tumor in occipito-suboccipital area. Microscopically, all tumors were identical in histology and were composed of spindle shaped cells with storiform pattern, foam cells and rare giant cells. Any mitotic figures were not detected. Clinical behavior was aggressive but histological figures suggested fibrous histiocytoma.(ABSTRACT TRUNCATED AT 250 WORDS)

Cerebellar Ataxia↗
PubMed1984

Carcinoembryonic antigen (CEA) levels in pleural effusions and sera of lung cancer patients.

For determining the value of carcinoembryonic antigen (CEA) levels in diagnosis of malignant tumors of the lung, the CEA levels in 187 specimens of pleural fluid and sera obtained simultaneously from patients with pleural fluid were measured. In all 70 patients with benign diseases, the CEA levels in the effusions were less than the cut-off value of 5 ng/ml (mean +/- SD: 1.44 +/- 1.01 ng/ml). In contrast, in 88 of 117 patients (75.2%) with malignant diseases, the CEA levels in the effusions were over 5 ng/ml (25.3 +/- 24.5 ng/ml) and in 58 of the 117 patients (50.4%), the CEA levels in the serum were values of 5 ng/ml or more (11.9 +/- 18.4 ng/ml). There was a significant correlation between the CEA levels in the effusions and in the sera. The CEA levels in effusions in patients with malignant lung tumors were usually much higher than those in their sera. The incidence of CEA levels of 5 ng/ml or more in both the serum and effusion was highest in the patients with adenocarcinoma. These data indicate that determination of the CEA level in effusions, when done in combination with cytological examinations, may have additional value in diagnosis of lung cancer.

Adenocarcinoma↗