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Biomedical subjects

M Sundaralingam

Publications and source records attributed to M Sundaralingam.

At least 163 records · Page 9Linked to original sources

Structures of the visual chromophores and related pigments: a conformational basis of visual excitation.

A detailed conformational analysis of the known crystal structures of vitamin A, carotenoid, and xanthenoid derivatives has been made. These studies suggest that the visual chromophore 11-cis retinal and its isomers may each occur in several different conformational states, which would be expected to have different lightabsorbing characteristics. The presence of such states for 11-cis retinal and all-trans retinal may contribute to the observed rhodopsin intermediates that have been characterized by different lambda(max) values, and to the breadth of spectral response in scotopic and color vision.

Carotenoids↗

Crystal structure of a naturally occurring dinucleoside monophosphate: uridylyl (3',5') adenosine hemihydrate.

The crystal structure of uridylyl (3',5') adenosine hemihydrate has been analyzed by x-ray diffraction. The two independent molecules found in the asymmetric unit exhibit conformations that differ significantly from those found in double-helical RNA. The conformational information obtained from this analysis provides considerable insight into the possible conformations of nonhelical "loop" regions of transfer RNA, as well as single-stranded regions of nucleic acids in general.

Base Sequence↗