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Biomedical subjects

M Sulik

Publications and source records attributed to M Sulik.

66 records · Page 4Linked to original sources
PubMedDate not supplied

Morphological changes in mitochondria and lysosomes of hepatocytes in acute intoxication with 2,4-dichlorophenoxyacetic acid (2,4-D).

The hepatotoxic effect of 2,4-dichlorophenoxyacetic acid (2,4-D) was investigated. Ultrastructural changes were evaluated under a transmission electron microscope. Certain histoenzymatic reactions were examined (to acid phosphatase according to Gomori (AP) and to succinic dehydrogenase (SD) according to Nachlas) in parenchymal cells of the rat liver in acute intoxication induced by this herbicide. The experiment used 60 male Wistar rats divided into two groups: I-control--18 animals and II--42 animals which received chemically pure 2,4-D acid by gastric gavage in a dose of 200 mg/kg b.w. The animals were sacrificed after 12, 24, 48 hours and 4, 10 and 30 days of the experiment. The results indicate that the administration of 2,4-D acid to rats in a dose inducing acute intoxication leads to histoenzymatic and ultrastructural changes in the liver, which suggest nonspecific reversible adaptive-type damage to parenchymal cells. The changes observed indicate disorders in energetic processes in hepatocytes and are morphological exponents of intense detoxicative processes.

2,4-Dichlorophenoxyacetic Acid↗
PubMedDate not supplied

[A case of "fibrositis" syndrome].

A case is described of a syndrome of pains in the lower extremities in a young man. After a number of diagnostic procedures the more common disease entities were excluded and "fibrositis" was accepted as the cause. The diagnosis was confirmed by EMG investigation, histological examination of dermomuscular specimens, positive effect of treatment and a 6-month follow-up.

Adult↗
PubMedDate not supplied

[Clinico-morphologic analysis of subacute sclerosing panencephalitis in patients up to the 19th year of life].

Deaths of patients with the subacute sclerosing panencephalitis were analysed in the non-selected autopsy material within 1976-1985. Fifteen cases of the disease, i.e. 0.12% of all autopsies and 3.8% of autopsies in the age group between 1 and 19 years, were noted. Fourteen cases of the subacute sclerosing panencephalitis were noted in the age group of 5-14 years. Mean age was 9.3 years. The disease was nearly three-fold more frequent in male patients. Time lapse between measles infection or antimeasles vaccination and hospitalization for the subacute sclerosing panencephalitis was 4.2 years for both sexes and was much lower for male patients--2.9 years. Morphological lesions characteristic for the subacute sclerosing panencephalitis were seen in the white matter and cortex of the brain in all examined patients. Lesions to the basal ganglia were noted in 9 cases, and additionally to the brain stem and vermiform lobe in 3 cases. The most frequent clinical symptoms accompanying the subacute sclerosing panencephalitis at the beginning of the hospitalization, other diseases and conformation of the clinical diagnosis with sectional findings are also discussed.

Adolescent↗
PubMedDate not supplied

[Multifocal periventricular leukomalacia in children up to 1 year of life].

The authors present an analysis of the multifocal leucoencephalomalacia in children under 1 year of life based on the material obtained from 2.398 autopsies. It was found that 32 autopsied children suffered from this disease (1.33%). Twenty four of these children were premature. The disease was more frequent in the infants (23 cases) than in neonates (9 cases), and in boys (20 cases) than in girls (12 cases). Multifocal leucoenephalomalacia was manifested mainly as spastic infantile paralysis in the majority of the infants (14 cases). Morphological lesions to the brain most frequently embraced white substance adjacent to the cerebral ventricles (foci of leucoencephalomalacia of 1 cm in diameter) and cerebral vessels. Widening of the ventricular system of the brain was seen in 15 cases. Pathological reaction resulted from the brain anoxia and ischemia in perinatal period (20 cases) or septicaemia (12 cases) while predisposing factors included: prematurity, respiratory failure with hyaline membranes in the lungs and congenital abnormalities of the heart.

Female↗
PubMedDate not supplied

[Coexistence of polycystic kidney and other developmental defects. Analysis of autopsy specimens 1953-1985].

The cases of polycystic disease of kidney selected from 33 years postmortem data were presented. They were classified into 4 types (according to Osathanond, Potter and Heptinstall) and the results correlated with accompanying malformations. It has been established that type I of polycystic disease of kidney was mostly correlated with CNS, skull and spine abnormalities. Type II and III were coexisting with genitourinary and ++gastrointestinal system malformations. No type IV of the disease has been found.

Abnormalities, Multiple↗
PubMedDate not supplied

[Some parameters of Guerin cancer growth after exposure to Pielik (sodium salt of 2,4-dichlorophenoxyacetate)].

Herbicide Pielik (sodium 2,4-dichlorophenoxyacetate) was tested with the aid of Guerin cancer animal model in 129 Wistar rats. An effect of this herbicide on the cancer growth dynamic (size and weight of the tumor), its malignancy (lymphatic nodes involvement), tumor-dependent animal cachexia (real body weight), and survival of rats depending on exposure period have been analysed. Aqueous solution of the herbicide was administered to animals of groups II, IV, V, and VI in the dose of 200 mg/kg body weight daily (1/3 LD50). Young rats were exposed to the herbicide during pre- and postnatal period till the death (groups III, IV and VI in the 80th day of life. Exposure to the herbicide was continued. Rats of all groups were sacrificed in the 16th, 20th, and 42nd day after implantation of Guerin cancer. Eight animals of each group were kept alive to assess survival. Accelerated growth of the tumor was noted in the animals exposed to the herbicide for the prolonged period of time (before and after birth). The same daily dose administered to the animals after weaning and continued to the 16th, 20th, and 42nd day of tumor development (group IV) has not significant effect on tumor growth rate. An increase in the incidence as well as earlier onset of metastases to auxillary and groin lymphatic nodes were seen in group VI in comparison with the control animals (group III).

2,4-Dichlorophenoxyacetic Acid↗