Search PubMed⌕ Search

Biomedical subjects

M Strauch

Publications and source records attributed to M Strauch.

At least 73 records · Page 4Linked to original sources
PubMed1985

The influence of two different essential amino acid/keto analogue preparations on the clinical status of patients with chronic renal failure.

58 outpatients with a serum creatinine between 6-10 mg/dl received a low protein diet (LPD) with 30 g protein/day, supplemented with essential amino acids (EAA) or their keto analogues (KA). Group A (n = 19) was given an EAA/KA supplement according to the pattern proposed by Rose and group B (n = 39) received a preparation with an increased amount of KAs of branched chain amino acids (BCKA), as recommended by Walser. At the start of treatment with a LPD supplemented with either of the two supplements and after 6 months of treatment we assessed: plasma branched chain amino acids (BCAA), renal function, nutritional status, and bone metabolism. After six months of dietary treatment the results showed in group B in contrast to group A an improvement of nutritional status (body weight increased, urea decreased, and BCAA normalized). The same was true for bone metabolism (significantly lower phosphate levels, increased calcium values). In both groups progression of chronic renal failure slowed down, but the delay was more pronounced in group B. All results were statistically significant (p less than 0.01).

Alkaline Phosphatase↗
PubMed1983

Low-protein diet supplemented by keto acids in chronic renal failure: a prospective controlled study.

In this prospective controlled study, a 30-g protein-restricted diet supplemented by keto acids resulted in a delayed rate of progression of chronic renal failure. The effect of this treatment differed according to the underlying renal disease. The rate of progression of chronic renal failure was delayed by a factor of at least 2. A need for long-term observations to quantify the effectiveness of this therapy is shown. A new pragmatic approach to the evaluation of long-term studies in patients with chronic renal failure is demonstrated.

Clinical Trials as Topic↗
PubMed1983

Predictability of the progression of chronic renal failure.

The progression of chronic renal failure has been claimed to be predictable by means of mathematical models. The present study assesses, in 110 adult patients, the prediction error caused by the application of these models. The study shows that the prediction error has a wide range, which indicates that these models should be used with caution for prediction purposes in individual patients. Improvements of the models are proposed, and a new approach is demonstrated.

Adult↗
PubMed1982

Juxtaglomerular apparatus of the human kidney: correlation between structure and function.

Electron microscopic and morphometric evaluation of the juxtaglomerular apparatus (JGA) of the human kidney showed the following: (1) The JGA of the human kidney consists of the epithelioid cells of afferent and efferent arterioles, the Goormaghtigh cells, and the macula densa, and it is abundantly supplied with sympathetic nerves. (2) The macula densa is in contact with the juxtaglomerular cell complex (JGC), the endocrine part of the JGA, via the Goormaghtigh cell field. The surface area of the macula densa is much larger than is the contact area with the JGA, totalling, in the healthy human kidney, some 66 cm2. (3) The total volume of all JGC's is 26 to 40 mm3. (4) Morphometric investigations of the JGC showed that appropriate stimulation by a decrease in the intrarenal or systemic blood pressure led to hypertrophy and hyperplasia of the JGC, which, in extreme cases, may also lead to a transformation of both the Goormaghtigh cells and mesangium cells into epithelioid cells.

Humans↗
PubMed1981

Identification of the nusB gene product of Escherichia coli.

Escherichia coli nusB mutants fail to support the activity of a phage lambda gene product, pN, which regulates phage gene expression by influencing transcription termination. We report the identification of the nusB protein on SDS-polyacrylamide gels as a 14,500 dalton protein.

Bacterial Proteins↗
PubMed1981

Extrarenal clearance, distribution volume, and elimination rate of digoxin and metildigoxin in anuric patients.

The pharmacokinetics of 3H-labeled digoxin and metildigoxin were compared in six anuric patients. The following means +/- s.e.m. were obtained: extrarenal clearance of digoxin, 43.3 +/- 5.4 ml/min, of metildigoxin, 30.3 +/- 2.9 ml/min; distribution volume of digoxin, 315 +/- 29 1, of metildigoxin, 258 +/- 22 1; rate constant for elimination of digoxin, 0.0086 +/- 0.0013 h-1, of metildogixon, 0.0071 +/- 0.0007 h-1. The elimination rates correspond to half-lives of 80 h for digoxin and of 97 h for metildigoxin. From our investigations and published data a weighed mean of 47 ml/min was calculated for the extrarenal clearance of metildigoxin. This is not significantly different from the mean extrarenal clearance of 40 ml/min reported for digoxin. A total body clearance of 40 ml/min and a daily intravenous dose of 0.1 mg correspond to an average steady-state glycoside concentration of 1.74 ng/ml.

Anuria↗
PubMed1980

Effect of islet transplantation on the glomerular changes in streptozotocin-diabetic rats.

Glomerular changes develop in rats with streptozotocin diabetes. The structure of these lesions (nodular and diffuse glomerulosclerosis, mesangial cell proliferation, basement membrane thickening, glomerular aneurysms, fibrinoid caps, glomerular adhesions) is described in the present paper and the effect of normalization of metabolism by islet transplantation on the glomerular changes is studied with histological, immunohistological and morphometric methods. Isogenous islets were transplanted into the portal vein of streptozotocin-diabetic rats after diabetes of 7 months' duration. The kidneys of normal, diabetic and transplanted animals of the same age were studied 2.5 months later. Studies of the kinetics of immunocomplexes in the mesangium were also performed. The renal changes (glomerulosclerosis, mesangial cell proliferation) were largely reversible after islet transplantation and the blood glucose level and glucose tolerance were normalized. In the diabetic animals the delayed uptake and elimination of immunocomplexes in the mesangium was normalized after the transplantation. It is possible, that the cause of the lesions is a functional disturbance of the mesangium induced by insulin deficiency and/or hyperglycaemia.

Animals↗