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Biomedical subjects

M Strauch

Publications and source records attributed to M Strauch.

At least 55 records · Page 3Linked to original sources
PubMed1988

Caloric supplements for patients on low-protein diets?

Protein-calorie malnutrition (PCMN) in patients suffering from chronic renal failure treated with a low-protein diet (LDP) is generally considered to be the major adverse effect of such a diet. One cause of PCMN might be that these protein-restricted diets do not supply enough energy, although all of them are supposed to provide at least 35 kcal/kg body weight (BW). In order to test this hypothesis, we analyzed the hypothetical protein and energy intake of a patient on different LPDs. The food intake of such a patient was simulated by analyzing the average composition of 28 complete daily menus. The daily menus simulating 9 dietary schedules (0.3 g protein/kg BW; n = 6; 0.6 g protein/kg BW; n = 3) were taken from 5 different German cookery books. Our analysis revealed that only 2 schedules supplied enough energy. All others were deficient in energy by about 500 kcal/day. The deficiency occurred to the same extent in schedules for diets providing 0.3 and 0.6 g of protein/day. Therefore we conclude that PCMN in patients on LPDs is often due to an insufficient energy supply. The use of less protein-restricted diets does not necessarily prevent PCMN, as also these diets may be low in calories. Thus the use of caloric supplements, e.g. wine or polysaccharides, and correct dietary counseling by a skilled dietitian are recommended.

Dietary Carbohydrates↗
PubMed1987

Influence of diet and underlying renal disease on the rate of progression of chronic renal failure.

The data presented demonstrate that the underlying renal disease and the type of diet used are considerably influencing the rate of progression of chronic renal failure. In relative terms the course of the renal disease is mostly changed in patients suffering from glomerulonephritis, while in absolute terms patients suffering from polycystic kidney disease exhibit the slowest rate of progression. The comparison suggests that a low-protein diet purely based on vegetarian food might considerably slow down the overall rate of progression of chronic renal failure. This finding is supported by results obtained in animal experiments.

Amino Acids, Essential↗
PubMed1987

Hyperfiltration due to amino and keto acid supplements of low-protein diets: influence on proteinuria.

In 12 male 5/6 nephrectomized Sprague-Dawley rats we analyzed the influence of commercially available amino/keto acid supplements on proteinuria. The addition of different supplements to an 8% protein diet resulted in an increase of preexisting proteinuria. Keto acids per se do not seem to cause a remarkable degree of proteinuria/hyperfiltration. Our data underline the importance of the protein content of a low-protein diet and the composition of amino/keto acid supplements, as these factors per se can cause hyperfiltration and might accelerate progression of chronic renal failure.

Albuminuria↗
PubMed1987

Hyperfiltration due to amino and keto acid supplements of low-protein diets: influence on creatinine clearance.

In 12 male 5/6 nephrectomized Sprague-Dawley rats we analyzed the influence of commercially available amino/keto acid supplements on creatinine clearance. The addition of different supplements to an 8% protein diet resulted in an increase of creatinine clearance. Keto acids per se do not seem to cause a remarkable increase in creatinine clearance/hyperfiltration. Our data underline the importance of the protein content of a low-protein diet and the composition of amino/keto acid supplements, as these factors per se can cause hyperfiltration and might accelerate progression of chronic renal failure.

Amino Acids, Essential↗
PubMed1987

Controlled trial of two keto acid supplements on renal function, nutritional status, and bone metabolism in uremic patients.

In this matched, controlled study, two different types of EAA/KA supplements were compared in uremic patients fed a 30 g protein restricted diet. The patients were paired for age, sex, and underlying renal disease. The supplement with the higher BCKA content resulted in an improvement of renal function, bone metabolism, and a normalization of plasma BCAA concentrations. With both supplements, adequate nutritional status of the patients was maintained. We conclude that the BCKA content of the supplement is of considerable importance for uremic patients on low protein diets.

Adult↗
PubMed1986

A new possibility to analyse urinary proteins: isoelectrofocusing with immobilized pH gradients.

As a new method for the analysis of proteinuria isoelectricfocusing with immobilized pH gradients is introduced. Ths new approach has several advantages over the conventional methods. The applicability is demonstrated by analysing the long-term changes in proteinuria of a 5/6 nephrectomized rat. Soon after 5/6 nephrectomy, a glomerular pattern of protein excretion predominates which later on is followed by a tubular pattern.

Aging↗