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Biomedical subjects

M Stoianova

Publications and source records attributed to M Stoianova.

At least 19 recordsLinked to original sources
PubMed1995

[A clinico-morphological study of cancer of the gastric stump following an operation for benign disease].

The study covers 108 patients with stomach resection (Billroth II), performed over a period of six years (1988-1993). Endoscopic and biopsy findings are described. Carcinoma of the gastric stump is established in 16 cases (14.8 per cent), high degree epithelial dysplasia-in six (5.5 per cent), and signs of acute or chronic anastomositis, superficial of atrophic gastritis, intestinal metaplasia, lipid islands and single hyperplastic polypoid lesions are present in all cases. Dysplasia III degree and carcinoma in the gastrojejunal junction are observed in the older age group with 10-15 years postoperative follow-up study. Patients with stomach resection should undergo check-ups and multiple biopsies at 3-5 years intervals, especially those with high-degree epithelial dysplasia.

Aged↗
PubMed1988

[Our experience of treating urological infections with a single dose of gentamycin].

31 patients with a urological infection caused by a bacterial strain susceptible to gentamycin were treated by a single injection of 240 mg of gentamycin. 11 patients (35.5%) fully recovered, the infection was eliminated and the clinical symptoms and signs disappeared. Better results were achieved in patients with infection of the lower urinary tract without pyelonephritis, 7 out of 15 patients (46%) recovered. Out of 16 patients with pyelonephritis only 4 were cured (25%). Of 10 patients with nephrolithiasis only 1 was cured, in the remaining 9 patients the treatment was without effect. In the group of patients who recovered the patients with E. coli infection prevailed while in the group of unsuccessfully treated patients other bacteria prevailed. No side effects were found. The conclusion is that the treatment with a single gentamycin dose could be applied successfully in patients with an infection of the lower urinary tract without pyelonephritis, morphologic changes in the urinary system or nephrolithiasis.

Adolescent↗
PubMed1987

[Nifedipine in the treatment of arterial hypertension].

The results are reported from the administration of nifedipine to 39 patients with arterial hypertension. Thirty one of the patients suffered from hypertonic disease, and 8 had symptomatic hypertension. Light hypertension was established in 26 of the patients, moderate--10 and grave--3. In 22 of the patients (66.6%)--16 with light and 6 with moderate hypertension, the arterial pressure was normalized by the administration of nifedipine alone, 40 mg daily. In 16 patients the arterial hypertension was coped with the addition of beta-blockers, diuretic and clonidine. Only one patient failed to respond to the treatment. The effect advanced on 3rd--4th day on the average with the treatment with nifedipine alone and after 4-6 days after the inclusion of the double combination. Negligible and transitory adverse effects were observed in single patients. Nifedipine, administered alone or in combination with beta-blockers, diuretic and clonidine is an excellent agent in the treatment of light and moderate arterial hypertension.

Adult↗
PubMed1986

[Systemic lupus erythematosus in elderly patients].

Two patients are described with lupus erythematosus, aged over 60. A brief literature survey is presented of the characteristics of SLE in advanced age, analyzed, in the light of the communications by other authors, were the manifestations in the described patients--fever, accelerated ESR, onset with preceding articular syndrome, skin changes as well as the complications--fresh myocardial infarction with the signs of activation of lupus in one of the patients.

Aged↗
PubMed1978

[Experimental study of the dynamics of alkaline phsophatase activity after a liver wound].

The investigation of alkaline phosphatase activity on 80 rabbits with an experimental model of liver wound showed the following results: 1. Alkaline phosphatase in blood serum was elevated considerably during the first postoperative days, but after the fifth day was close to the normal ranges. 2. Tissue alkaline phospatase sharply fell up to the third day. Its values began to raise after the 20th day and reached the normal level in the end of the experimental period (30th day). 3. Histochemical studies of liver wound showed a positive reaction for alkaline phosphatase in the cells of the inflammatory infiltrate during the first days. Increased phosphatase activity was demonstrated in fiber structures, epithelium of bile canals and capillary endothelium. The dynamics of alkaline phosphatase activity in blood serum is a reflection of the delicate biochemical and histochemical changes in the liver wound. The follow-up of serum alkaline phosphatase together with the clinical course of healing could be an useful index for evaluation of diet and working capacity of the patient.

Alkaline Phosphatase↗