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Biomedical subjects

M Stauch

Publications and source records attributed to M Stauch.

At least 91 records · Page 5Linked to original sources
PubMed1980

Assessment of left ventricular function during angina pectoris from the mitral valve echogram.

The echocardiographic motion pattern of the anterior mitral valve (aMV) has been shown to be related to left ventricular function. In an attempt to quantify the changes of aMV motion in patients during myocardial ischemia, the following motion phases of the aMV echo were determined in 12 patients with coronary artery disease: DE slope, EF slope, the closure slope of the aMV, as determined by joining points B and C (or in the absence of a clearly definable B point the AC slope), and the systolic motion pattern. Following coronary angiography, measurements of the aMV echo were performed in the resting state and during angina pectoris immediately after rapid atrial pacing at comparable heart rates. DE slope and EF slope showed only minor and insignificant changes during angina in the post-pacing period. The aMV closing velocity (BC or AC slope) was significantly reduced from 225.9 +/- 56 mm/sec during the control period to 177.9 +/- 43 mm/sec during angina (p < 0.01). After recovery from anginal pain measurements of the final closing velocity revealed a return to the control values with an average slope of 240.4 +/- 40 mm/sec. In 3 of 12 patients there was evidence of systolic mitral valve prolapse during the post-pacing anginal episode. Our results suggest that final mitral valve closing velocity reflects changes in left ventricular function during myocardial ischemia in the early isovolumetric phase of ventricular systole. In some patients mitral valve prolapse during angina may indicate ischemic dysfunction of the papillary muscles during the ejection of phase of systole.

Adult↗
PubMed1979

Assessment of regurgitation fractions by radionuclide ventriculography.

The ratio A for left ventricular and right ventricular enddiastolic-endsystolic count differences was used for quantitative evaluation of aortic and mitral valve regurgitation. The mean value of A for patients without valvular insufficiencies was determined (Am = 1.43 +/- 0.27).23 (96%) of 24 patients with aortic or mitral valve regurgitation showed significantly increased A values (A greater than 2). The numerical value was used for classification of the degree of insufficiency and for comparison with angiography. The correlation between A and the average angiographic degree of insufficiency was 0.79.

Angiography↗
PubMed1978

[Radionuclide ventriculography. I. Fundamentals and methods (author's transl)].

Using local time activity curves parameters are calculated which depend on the local wall motion of the heart cavities. These functional parameters allow the determination of the contours of the heart cavities and the assessment of segmental wall motion disorders. The left ventricular ejection fraction has been calculated by enddiastolic and endsystolic counts using a method which takes into account background inhomogeneity.

Electrocardiography↗
PubMed1978

[Radionuclide ventriculography. II. Clinical results--parameters of global ventricular function (author's transl)].

The ejection fraction as determined by gated blood pool studies was compared with the ejection fraction as evaluated by the following conventional methods: 1) biplane cineangiography employing the Simpson rule. Correlation was r = 0.805 (n = 25); 2) the same patients using the area-length method (r = 0.88, n = 25); 3) monoplane cineangiography using the method of Greene et al. (5) (r = 0.86, n = 35). In 20 patients the maximal contraction velocity as evaluated by radionuclide ventriculography was compared with the mean systolic ejection rate. The observed correlation was weak (r = 0.62, n = 20); however, it should be noted that the radionuclide method determines the maximum contraction velocity whereas cinceangiography measures an average value over the whole systole.

Cineangiography↗
PubMed1978

[Radionuclide ventriculography. III. Clinical results--parameters of regional wall motility (author's transl)].

Radionuclide ventriculography and cineangiography were performed in 62 patients with suspected coronary artery disease. Regional wall motility irregularities could be demonstrated in 97% of those patients who revealed an irregularity in the cineangiogram. Two small scars of the posterior myocardial wall escaped detection. The sensitivity of the radionuclide ventriculography was 97%, the specificity was 80%, 4 patients with normal cineangiography showed small irregularities in the radionuclide ventriculogram. 70 patients with infarction revealed wall motility irregularities in 90%, whereas perfusion defects could be detected by thallium scintigraphy in 66% (young and old infarctions).

Cineangiography↗
PubMed1977

[Influence of molsidomine on exercise-ECG'S In coronary insufficiency (author's transl)].

Molsidomine was shown to have a strong pain-relieving action in 22 coronary patients investigated one hour after oral intake of 2 mg of the substance. During comparable maximal exercise load the ST interval lowering was reduced from an average of 0.22 mV to 0.09 mV (P less than 0.0005). At the termination of exercise it was still reduced from 0.23 mV to 0.12 mV (P less than 0.0005). At the same time the exercise tolerance increased from 570 to 717 Watt-minutes (P less than 0.0025). Pectanginal complaints were clearly reduced at the same exercise loads, 11 patients became symptom-free at the same load. Even when exercise loading was stopped at higher loads a decrease of the severity of angina pectoris could be shown. Seven patients became symptom-free at that stage. The heart rate was not influenced markedly at rest and during exercise. Systolic blood pressure was reduced from 135 mm Hg to 118 mm Hg (P less than 0.0005), and in comparable submaximal loads from 177 to 165 mm Hg (P less than 0.005).

Administration, Oral↗
PubMed1977

[Oral longterm therapy with disopyramide phosphate in patients with atrial and ventricular arrhythmias (author's transl)].

The antiarrhythmic effect of longterm therapy with disopyramide phosphate (DP) was investigated in a single controlled trial in 34 patients. Of 11 patients with atrial fibrillation, 5 were successfully cardioverted to sinus rhythm with DP in the long run. In the treatment of extrasystole, the arrhythmia was eliminated or reduced by 75% in 15 of 23 patients. In 6 cases a moderate improvement was achieved and there was no change in 2. The average daily dose initially was 4.2 capsules, the maximum dose was 5.4, and for longterm therapy 4.3 capsules. With respect to its indications, DP is largely similar to quinidine, but in our experience it is characterized by better tolerance.

Adolescent↗
PubMed1977

[Effect of proscillaridin-4'-methylether on pressure rise velocity in the left ventricle of patients with coronary heart disease (author's transl)].

In a randomized, controlled, double-blind study 2 groups of 7 patients each with coronary heart disease received either 1 mg methylproscillaridin (MP) a cardiac glycoside of the squill intravenously, or placebo to test the inotropic effect of MP. Pressures and dp/dt max were measured in the left ventricle before and after coronary angiography after an average of 62 min (60 to 70 min). There was a significant (p less than 0.05) increase of dp/dt max in the MP-group (Wilcoxon-Mann-Whitney test). Left ventricular enddiastolic pressure was decreased from 16.1 to 13.6 mm Hg in the MP-group, and increased in theplacebo group from 12 to 13.7 mm Hg (mean values). Thus, a positive inotropic effect of the glycoside may be assumed.

Angiography↗
PubMed1977

[Regional myocardial motility as evaluated by analysis of "gated blood pool" data (author's transl)].

Cyclic precordial variations of radiation after i.v. administration of 15 mCi 99mTc-HSA correspond to cyclic volume changes of ventricular volumes of the heart. The "gated blood pool procedure" yields reliable data. Extensive analysis of these data results in subsequent information concerning left ventricular myocardial behaviour: 1. extent of the regional myocardial contraction 2. homogeneity of the contraction 3. regional contraction velocity 4. regional relaxation velocity. Four parametric scans present the distribution of each one of those parameters within the heart. Gated blood pool data have been compared with angiographic data. Reliability of those parameters obtained by extensive analysis of the gated blood pool data could be proven.

Adult↗