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Biomedical subjects

M Staak

Publications and source records attributed to M Staak.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Mnemic disturbances following experimental alcohol-tranquilizer application (author's transl)].

Mnemic disturbances occurred in 8 of 14 subjects during a pharmcopsychological investigation of possible interactions between alcohol and dipotassium chlorazepate (Tranxilium). The blood alcohol concentrations were between 0.87% and 1.32%; the serum concentrations of the active metabolite nordiazepam were in the therapeutic range between 145 ng/ml and 345 ng/ml. The constitutional, dispositional, and situative conditions are presented. The forensic medical interpretation of such mnemic disturbances must be made critically and with reservation when evaluating a psychopathological state.

Adult↗
PubMed1980

Pharmacopsychological investigation of changes in mood induced by dipotassium chlorazepate with and without simultaneous alcohol administration.

The effects on subjective well-being of a single oral dose of 20 mg dipotassium chlorazepate (DPC) with and without concurrent alcohol administration (1 g/kg) were tested on 14 male students. A reciprocal effect on the pharmacokinetics was not detected. The personal feeling scale and the semantic differential revealed an emotional damping 90 minutes after oral administration of DPC in the evening test. Under concurrent alcohol administration the alcohol-typical euphoric effect was increased by DPC and the dysphoric symptoms were reduced the following morning.

Adult↗
PubMed1979

[Human experimentation and criteria for obligatory medical care].

Human experiment and therapeutic trials are regulated by the drug law and the jurisdiction of the supreme court. The qualification of the trial leader and the personification of his responsibility with reference to indication, performance and evaluation of the trial are just as much criteria of his obligations as the protection--derived from medical ethical motives--of the patient or subject. It would certainly be welcomed if the legal regulations affecting the testing of drugs could simply be transferred to clinical research in humans and dispense with the all too closely meshed regimentation.

Adult↗
PubMed1979

Pharmacopsychological investigations concerning the combined effects of dipotassium clorazepate and ethanol.

The effect of a single dosage of 20 mg dipotassium clorazepate (DPC) on reaction times, with and without administration of ethanol (1 g/kg body weight), was studied in 14 male subjects. When administered in the evening, the sort-term effect of DPC consisted of slightly increased optic reaction times and decreased endurance and concentration. With simultaneous administration of ethanol, all types of performance studied were significantly impaired; impairment was more pronounced than with the ethanol tests. On the following morning at the second retest, performance levels almost completely returned to those at the onset of testing. This restitution, however, was not as pronounced with subjects who had only received DPC.

Adult↗
PubMed1978

[Pharmacokinetic studies on interactions between dipotassium clorazepate and alcohol after oral application (author's transl)].

Pharmacokinetic investigations concerning possible interactions of an orally administered single dosage of 20 mg dipotassium clorazepate and ethanol were conducted with 14 male subjects. Blood alcohol concentrations did not appear to be influenced by dipotassium clorazepate or its metabolites nordiazepam and oxazepam. The increase in oxazepam glucuronide excreted in the urine, however, was statistically significant. Nordiazepam concentration in the serum differed considerably between the group with ethanol administration and the control group. This metabolization pattern is apparently the result of the inhibitory effect of ethanol on hydroxylization processes during biotransformation of the metabolite nordiazepam.

Administration, Oral↗
PubMed1977

[Psychopharmacologic studies on the combined effect of alcohol and oxazepam on reactivity pattern. II. Subjective feeling and reaction behavior].

Psychopharmacological investigations of the subjective state of being and the reactivity pattern of a group of 14 probands show a good agreement with the alterations of performance reported in the first part of this publication and with the data on polarity profiles. In addition to a sedative effect the interaction of alcohol and oxazepam in the oxazepam trial results in dysphoric changes of mood and related significant alterations of polarity profiles. A correlation of the changes of performance and the alterations of the polarity profiles with the respective blood levels of alcohol and oxazepam could be demonstrated.

Behavior↗