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Biomedical subjects

M Staak

Publications and source records attributed to M Staak.

At least 73 records · Page 4Linked to original sources
PubMed1984

[Sudden death in medical practice. Quality assurance and control as a task of forensic medicine].

During the last twenty years 72 deaths occurred in Cologne in medical practices. The cause of death was determined by autopsy on judicial order in 13 cases only. Public interest in complete diagnosis existed only in case of acute death during a medical intervention. Where there was no such interest, but clarification was possible in the sense of a quality control, the autopsy rate was below 20%. In all other cases the cause of death was certified in accordance with clinical findings, usually as cardiac death. In 87% of all cases the death certificate had been signed by the doctor who had last treated the patient. In 57% the certified cause of death could be based on a knowledge of the underlying disease. A closer collaboration between practising doctors and forensic pathologists is desirable for the purpose of quality control.

Autopsy↗
PubMed1983

[Capacity for activity in penetrating and blunt abdominal injuries].

In the archives of the accident hospitals available, the data of patients who had been hospitalized because of a penetrating or blunt abdominal trauma in the last two years before the surveys were evaluated. Besides the abdominal trauma, at most trivial injuries of other regions were permitted. The data which might give information on how massive the intraabdominal injury was and/or the severity of shock symptoms were taken from the patient record sheets. Afterwards, it was attempted to obtain in an interview details on the external circumstances, the course of the accident event itself and the nature of the reaction to the trauma. Finally, 32 casualties (14 with penetrating and 18 with blunt abdominal injury) were surveyed. Fundamental differences in the behavior of these two subgroups were detected and verified with statistical test techniques. Circumspect behavior after penetrating abdominal trauma was characteristic. Nevertheless, in a few cases there was loss of the ability to act even in limited penetrating injury of the abdominal wall. However, the casualties themselves had the impression of a severe stab injury and this determined the primary reaction to the trauma. A fundamentally different behavior pattern was shown by those who had suffered a blunt abdominal injury. For them, it was typical that they became unable to act immediately or within a few seconds. With regard to the significance of pain, the restriction of motor movements as well as the relation of assumed and clinically verified injury severity is dealt with in respect of the capacity to act in a comparison of the two subgroups.

Abdominal Injuries↗
PubMed1982

[Pulmonary alveolar microlithiasis].

We report the case of a 33-year-old man who suddenly died with the symptoms of a cardio-respiratoric insufficiency. As cause of death we found pulmonary alveolar microlithiasis (MAP) with intra-alveolar calcifications and fibrosis of the alveolar margin. It is not known whether this diagnosis was found during lifetime. In our forensic experience we never met a case of this rare illness causative of sudden natural death.

Adult↗
PubMed1982

[Pharmacokinetic studies after oral and parenteral application of dipotassium chlorazepate (author's transl)].

Pharmacokinetic investigations after oral and intravenous application of 50 mg and 100 mg 7-chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carbonic acid (dipotassium clorazepate, DPC, Tranxilium, Tranxène) were conducted with two groups of male subjects (A: N = 7; B: N = 6). DPC and its metabolites, nordiazepam (ND) and oxazepam (OX), were measured in blood and urine. After oral application of DPC the expected metabolite pattern was observed. But after i.v. infection of 50 mg or 100 mg DPC a rapid increase of DPC- and also ND-concentrations in the serum was shown. The pattern of the metabolites excreted in urine differed considerably between the groups with oral and i.v. administration of DPC. The possible causes of rapid biotransformation in the serum are discussed.

Administration, Oral↗