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Biomedical subjects

M Sone

Publications and source records attributed to M Sone.

At least 145 records · Page 8Linked to original sources
PubMed1989

[Giant liposarcoma of the spermatic cord: a case report].

A case of giant liposarcoma of the spermatic cord was reported. A 75-year-old man was admitted with a 25-year history of a slowly growing left scrotal solid mass without trans-illumination. The removed huge mass measuring 26.0 x 16.5 x 20.0 cm and weighing 4,500 g was confirmed to be a well-differentiated liposarcoma according to WHO classification. The patient died of acute pneumonia 5 months later, although the postoperative course was uneventful and he had no sign of recurrence.

Aged↗
PubMed1988

Continuous narcotic infusion with patient-controlled analgesia for chronic cancer pain in outpatients.

STUDY OBJECTIVE: To determine the feasibility and safety of outpatient continuous narcotic infusions with additional bolus capabilities (patient-controlled analgesia) in patients with cancer pain. DESIGN: A single arm (non-randomized) series. SETTING: Outpatient with contact by telephone and through outpatient clinic. PATIENTS: Consecutive series of 18 patients with poorly controlled cancer pain or significant side effects from regular administration of various narcotics. INTERVENTIONS: Patients taught and supervised to use portable pump capable of delivering a continuous narcotic infusion with bolus capabilities. MEASUREMENTS AND MAIN RESULTS: All patients had improvement in pain control as judged by the use of a linear analogue scale. Side effects and safety profile were highly acceptable. Narcotics used and maximum doses were meperidine, 50 mg/h; morphine, 80 mg/hr; and hydromorphone, 60 mg/hr. Infusion duration ranged from 7 to 225 days (mean, 54 days). CONCLUSIONS: Continuous narcotic infusions using a programmable portable pump with bolus capabilities is a safe and reliable method of delivering narcotics to outpatients.

Adult↗
PubMed1987

Rapid procedure for preparation of macrophage plasma membrane.

This report describes a simple and efficient procedure for the isolation of plasma membrane from guinea pig peritoneal macrophages. The use of polycationic beads (Affi-gel 731 beads) facilitates rapid and high-clear separation of plasma membrane within 30 min. The final plasma membrane coated beads fraction has high specific activities of marker enzymes with little contamination with mitochondrial, lysosomal or cytoplasmal markers.

Animals↗
PubMed1987

Increased plasma immunoreactive neuropeptide Y concentrations in phaeochromocytoma and chronic renal failure.

To investigate the clinical usefulness of radio-immunoassay of neuropeptide Y (NPY), we measured plasma immunoreactive neuropeptide Y (IR-NPY) concentrations in normal subjects (n = 21), essential hypertensive patients (n = 33), patients with phaeochromocytoma (n = 7), patients with chronic renal disease with serum creatinine levels of less than 1.9 mg/dl (n = 5) and patients with chronic renal failure whose serum creatinine levels were greater than or equal to 1.9 mg/dl (n = 18, eight without haemodialysis and 10 undergoing maintenance haemodialysis), by radio-immunoassay. Plasma IR-NPY concentrations in patients with phaeochromocytoma (577 +/- 256 pg/ml, mean +/- s.d.) were significantly higher (P less than 0.001) than those in normal subjects (151 +/- 28 pg/ml), essential hypertensive patients (177 +/- 49 pg/ml) and patients with chronic renal disease with serum creatinine levels less than 1.9 mg/dl (198 +/- 71 pg/ml). Plasma IR-NPY concentrations in patients with chronic renal failure (without haemodialysis: 330 +/- 63 pg/ml; undergoing maintenance haemodialysis: 374 +/- 80 pg/ml) were also high. These results suggest that NPY is useful as one of the tumour markers of phaeochromocytomas. However, this study revealed that patients with chronic renal failure, without phaeochromocytoma also have increased plasma IR-NPY concentrations.

Adrenal Gland Neoplasms↗
PubMed1987

Renal effects of synthetic rat-atrial natriuretic peptide in nephron-reduced rats with nephrotoxic nephritis.

Following nephron reduction by means of five--sixths nephrectomy (Nx), nephritis was induced in rats by injection of nephrotoxic serum (NTS). A continuous intravenous infusion of synthetic rat--atrial natriuretic peptide (r-ANP) at 2.5 micrograms/min for produced remarkable diuresis and natriuresis in these rats. Furthermore, inulin clearance, para-amino-hippuric acid clearance and filtration fraction increased in spite of the reduction of mean arterial pressure during the infusion of r-ANP. It was therefore evident that diuresis and natriuresis were mediated by a direct action of r-ANP in the kidney. We observed that r-ANP was a diuretic, natriuretic and hypotensive agent but at a higher dosage in Nx rats with NTN.

Animals↗
PubMed1986

[Determination of the N-acetyltransferase phenotype in urothelial cancer patients and healthy controls].

Several arylamines can act as human urothelial carcinogen and N-acetyltransferase, human liver enzyme, might play a role in the detoxication of these carcinogenic substances. N-acetyltransferase phenotype in man is genetically regulated and divided into the rapid type and the slow type. The N-acetyltransferase phenotype was determined to investigate the susceptibility for bladder cancer in the slow acetylator phenotype using the method reported by Weber and Brenner. The frequency of the slow acetylators was 16 of the 144 subjects (11.1%); 1 of the 25 controls (4.0%), 10 of the 57 chemical workers (17.5%), 3 of the 42 spontaneous urothelial cancer patients (7.1%) and 2 of the 20 occupational urothelial cancer patients (10.0%). These results showed no significant association between the slow acetylator phenotype and the urothelial cancer. These results seemed to be caused by the low ratio of the slow acetylator in Japanese people.

Acetylation↗
PubMed1985

Venous access ports.

Explore the source record for details and available documents.

Catheters, Indwelling↗
PubMed1984

Purification of swine kidney alkaline phosphatase by immunoaffinity chromatography.

A homogeneous alkaline phosphatase preparation was obtained from swine kidney cortex by a simple purification step of immunoaffinity chromatography. The enzyme was purified 426 times that of the initial acetone powder with a recovery of 69.6% and a specific activity of 1206 units/mg of protein. The sodium dodecyl sulfate-gel electrophoretic pattern showed a single 80,000-Mr protein band as the monomer of the purified enzyme.

Alkaline Phosphatase↗
PubMed1982

Effects of various antibiotics on the control of bacteria in boar semen.

Nine antibiotics were tested for the control of 11 bacterial genera isolated from boar semen. Of the antibiotics tested, the aminoglycosides dibekacin, amikacin and gentamicin proved fairly effective. Minimum inhibitory concentrations of those antibiotics were low (less than 6.25 micrograms/ml) compared to those of antibiotics commonly used for semen diluents. Seventy-four semen samples were stored at 15 degrees C by means of dialysis in the presence of dibekacin (100 micrograms/ml). After seven days' storage, about 80 per cent of the samples showed no bacterial growth and the mean values for sperm motility an normal acrosomes were 75.4 per cent and 82.7 per cent respectively. Twenty sows which were inseminated with semen stored for up to 14 days produced 16 litters and the average litter size was 9.9.

Amikacin↗
PubMed1981

Factors affecting the quality of boar semen stored by means of dialysis.

The effects of dialysis fluids containing blood serum, serum albumin or activated charcoal on the storage of boar serum were examined. The effects of antibiotics were also tested by including them in the dialysis fluids and semen samples. Undiluted semen was stored for 7 days at 15 degrees C by means of dialysis across a cellulose membrane. A combination of sulbenicillin and streptomycin was superior to that of penicillin and streptomycin in reducing bacteria and maintaining sperm motility and normal acrosomes. Serum albumin exerted a beneficial effect on the stored spermatozoa which may be due to its capacity to adsorb the metabolic products from bacteria and spermatozoa; it could be replaced with activated charcoal.

Acrosome↗