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Biomedical subjects

M Sigal

Publications and source records attributed to M Sigal.

At least 73 records · Page 4Linked to original sources
PubMed1987

[Stewart-Treves pseudo-syndrome caused by cutaneo-lymphatic metastases of contralateral breast carcinoma].

The pathogenesis of Stewart-Treves syndrome remains controversial: angiosarcoma or epithelial cell metastases from a mammary carcinoma? The case reported here, with clinical signs of Stewart-Treves syndrome on one side and mastectomy for carcinoma on the other side of the body, revives the debate. Case-history. The patient was an 89-year old woman whose left breast had been removed in June, 1981 for carcinoma with lymph node involvement. One year after the operation, multiple lymphadenopathy developed in her right armpit and subclavian region. In December, 1984, her right arm became swollen by lymphoedema, while Kaposi-like and nodular skin lesions appeared on her right upper chest and upper back and on her right shoulder and arm. Radiography of the chest showed right pleural effusion, bronchial lymph node enlargement and a reticulate image in the right lung. In spite of chemotherapy, the patient died in April, 1985. Pathology. Pathological examinations included standard histology (HPS, PAS and Gordon-Sweet staining), immunohistochemistry, using anti-factor VIII, anti-keratin KL1 and anti-EMA antisera, and electron microscopy. Results. Irrespective of the skin area biopsied, the histological images were always the same, showing carcinomatous lymphangitis with a varying degree of invasion of the surrounding dermis. Staining of the reticulum enhanced the vascular basal membranes but did not mark the intraluminal tumoral cell population. Post-mortem examination confirmed that the malignant lymphangitis extended to the lung tissue, the oesophageal wall and the adrenal glands, and that the axillary and subclavian lymph nodes were invaded by metastases.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1985

Cognitive impairment in patients with tardive dyskinesia.

Schizophrenic patients with (N = 17) and without (N = 14) tardive dyskinesia performed several neuropsychological tests. Most patients (88%) showed complete lack of concern or anosognosia with regard to their involuntary movement. A marginally significant difference was found in recall of pictures presented in the right hemispace. It is suggested that when patients with organic brain disorder and a low Mini-Mental State score are excluded, neuropsychological tests do not differentiate between tardive dyskinesia patients and nonhyperkinetic controls. The results are discussed in relation to hemispheric asymmetries in schizophrenia.

Aged↗
PubMed1985

[Early congenital syphilis: apropos of 5 cases].

Congenital syphilis has in large part disappeared in countries where antiveneral legislations and preventive measures are well developed. In France, although there is no declaration of congenital syphilis between 1971 and 1983 in the official statistics of the Paris region, congenital syphilis is nevertheless mentioned as sporadic cases. The authors report here five cases of precocious congenital syphilis collected from august 1981 to december 1982 by a department of antiveneral consultations in the Paris region.

Doxycycline↗
PubMed1984

[Cowden's disease or the multiple hamartoma syndrome].

Cowden's disease, also called multiple hamartoma syndrome, is a clinical entity characterized by hamartomatous tumours of endodermal, mesodermal and ectodermal origin. Although extremely rare, the disease must be known to all internists. A case of Cowden's disease in a 36-year old male patient is reported. The authors insist on the high incidence of digestive disorders and the risk of malignant degeneration of mammary and thyroid tumours. They also describe the cutaneous and mucosal lesions characteristic of the disease.

Adult↗
PubMed1984

[Cutaneous lesions induced by long-term use of hydroxyurea].

The authors report 3 cases of patients having myeloid chronic leukemia presenting skin changes after long-term hydroxyurea therapy. Some of these side effects are already known; such as dryness, pigmentation, spontaneous necrotizing ulceration and chromonychia with longitudinal pigmented bands. Two new signs are described: a band-like erythema on the dorsum of the fingers and toes, as in dermatomyositis and a plantar keratoderma which interpretation is difficult in such a context. The hydroxyurea's imputability is discussed. These lesions altogether are very suggestive of skin changes after hydroxyurea therapy. The occurrence of such phenomena is quite frequent.

Aged↗
PubMed1981

Antibodies to Epstein-Barr virus, herpes simplex type 1, cytomegalovirus and measles virus in psychiatric patients.

Distribution of antibodies to herpes simplex type 1 (HSV1), Epstein-Barr virus (EBV), cytomegalovirus (CMV) and measles virus (MV) was studied in sera and cerebrospinal fluids (CSF) of 41 patients with schizophrenia, 27 patients with primary affective disorders and 25 control patients with neurological diseases. No significant differences in distribution and mean geometric titers (GMT) of antibodies to HSV1 between the psychiatric and control groups were found. Distribution and GMT of antibodies to EBV were highly significant in psychiatric patients as compared to controls with highest titers in the affective disorder group. Antibodies to HSV1 were present in 15 CSF specimens of psychiatric patients with reduced CSF/serum ratio in 4, and low levels of antibodies were detected in 8 control patients. Antibodies to EBV-VCA were detected in 4 CSFs of psychiatric patients. Total protein levels were determined in CSF specimens and no correlation with antibodies was found. No significant differences in distribution of antibodies to CMV or MV in the three study groups were found. No antibodies to CMV were demonstrated in CSFs and in one specimen from a patient and two controls antibodies to MV were detected.

Affective Disorders, Psychotic↗
PubMed1978

Relationship between presumed etiological factors and clinical picture in 100 schizophrenic males.

The schizophrenic syndrome, in one form or another is a result of combinations of genetic, organic and psychosocial factors. 100 schizophrenic males were studied and etiological factors such as schizophrenia or affective illness in direct relatives, brain damage or temporal lobe epilepsy, an over-protective parent or latent homosexuality were isolated. The findings show a relationship between these etiological factors and the clinical picture and course and an attempt is made to use the etiological factor in classifying schizophrenia.

Adult↗