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Biomedical subjects

M Shah

Publications and source records attributed to M Shah.

At least 181 records · Page 10Linked to original sources
PubMed1988

Metabolic rate during and after aerobic exercise in post-obese and lean women.

The effect of aerobic exercise (cycling on bicycle ergometer for four 10-min periods/60-80 per cent max VO2) on energy expenditure following the activity was investigated in 16 post-obese and 16 lean control women over 24 h and shorter periods. In addition, net energy expenditure during aerobic exercise was compared to that during prolonged mild activity (stepping for four 30-min periods at 12 steps/min). The measurements were made in a room respirometer. Aerobic exercise did not significantly stimulate the 24-h resting metabolic rate of either the post-obese (3 per cent, 50 kcal) or lean controls (2 per cent, 30 kcal), nor was there any significant stimulation over shorter periods: during waking hours RMR was non-significantly increased by 5 per cent in both the post-obese and lean controls. Sleeping expenditure remained the same in the post-obese and was decreased by 2 per cent in the lean controls. All subjects found the aerobic exercise to be quite uncomfortable, yet in both groups the net cost was smaller than that of prolonged mild exercise which was found to be acceptable (post-obese: aerobic 180 kcal, mild 250 kcal; lean controls: 220 kcal, 290 kcal). It is suggested that prolonged mild activity (eg, as in walking frequently) is more appropriate in increasing energy expenditure as a means of preventing or controlling obesity. Total expenditure at each level of activity is also expressed as multiples of BMR calculated from FAO/WHO/UNU (1985) prediction equations and from measured sleep values. The results show that the equations overestimated BMR in the post-obese.

Adult↗
PubMed1987

The daily metabolic rate of the post-obese and the lean.

Daily metabolic rates of 16 post-obese women and 16 matched, lean controls were measured at three different levels of activity in a room respirometer. Both groups had similar height, weight, age, and other anthropometric indices. Results show that the post-obese have metabolic rates approximately 15% lower than their controls at any level of activity. They also eat less. Slimmed-down, obese women have a normal body composition. For both groups, aerobic exercise did not have a prolonged stimulatory effect on metabolic rate after the exercise had finished. Mild exercise was more effective than aerobic exercise in increasing daily metabolic rate because it could be comfortably sustained for a longer time. Implications of these findings are discussed in relation to the etiology and treatment of obesity.

Activities of Daily Living↗
PubMed1986

Graft versus host-like illness in a child with phenobarbital hypersensitivity.

A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described. Laboratory studies demonstrated eosinophilia, elevated serum IgE, and elevated T suppressor/cytotoxic cells in the peripheral blood. Findings from biopsy specimens of skin and jejunum suggested a cell-mediated pathogenesis, and lymphoproliferative studies of the patient's mononuclear cells revealed a positive response to phenobarbital. The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.

Antigen-Antibody Complex↗
PubMed1984

Callosal syndrome: implications for understanding the neuropsychology of stroke.

A case is presented of callosal syndrome following cerebral hemorrhage and amphetamine abuse in a 26-year-old right-handed man. There were few hemispheric findings but a full callosal syndrome including left apraxia to verbal commands, left tactile anomia, left agraphia, right constructional apraxia, failure of blindfolded side-to-side hand replication and form-board testing showing loss of interhemispheric transmission including intermanual interference. The "draw-a-clock" test showed left inattention when drawn with the right hand but not the left, and perseveration was noted for spatial tasks done with the right hand and symbolic tasks done with the left. The patient recovered functionally almost completely but testing demonstrated continued loss of interhemispheric transmission. The case is considered of most interest for its potential in explaining phenomena observed in severe unilateral hemispheric lesions. Our findings suggest that perseveration is not a dysfunction of the damaged portion of the brain, but a phenomenon associated with intact brain attempting unfamiliar tasks. The persistence of left hemi-inattention is attributed to the inability of the left hemisphere to utilize spatial information to compensate for the phenomenon of inattention. Left-sided dyskinesia following left hemisphere lesions was attributed to the lack of symbolic information necessary to perform some movements. Dysprosody was attributed to lack of tonal information to the left hemisphere. Recovery of function following severe unilateral lesions may be largely due to compensatory learning by the intact hemisphere and assertion of ipsilateral control. As our patient originally assumed an inverted left-handed writing posture, we assume the posture is controlled by the right hemisphere.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Chronic liposome administration in mice: effects on reticuloendothelial function and tissue distribution.

Liposomes have a pronounced tendency to localize in the reticuloendothelial (RE) system, a major host defense system. We have examined, in mice, the effect of chronic i.v. administration of low to moderate liposome doses on drug metabolism, phagocytic index and spleen and liver size. Little effect on the rate of pentobarbital metabolism was noted, except when mice received 80 mg/kg of sphingomyelin-containing liposomes in a series of 10 injections over 3.5 weeks. Impairment of RE phagocytic function was found to be related to liposome size and composition, size and frequency of liposome dose and the presence of lipid peroxides. The effects on tissue distribution of liposome-entrapped [14C]sucrose was also determined in mice receiving chronic liposome injections. In RE blockaded mice there was a consistent trend in favor of decreased liver uptake and increased spleen uptake. No significant uptake of liposome contents was seen in non-RE tissues even in mice with severe RE blockade, indicating that the induction of RE blockade by predosing with empty liposomes may not be a successful strategy for increasing liposome uptake to non-RE tissues. Liver to spleen ratios of [14C]sucrose appeared to be a sensitive method for quantitating RE blockade. Sphingomyelin-containing liposomes produced the greatest RE blockade, distearoylphosphatidylcholine-cholesterol liposomes were intermediate and egg phosphatidylcholine-cholesterol liposomes produced the least impairment in RE function. Liposomes which contained 1% vitamin E as an antioxidant had slightly less effect on RE function than liposomes not containing vitamin E.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1983

The efficacy of face masks.

Photographs of smoke particles expelled by coughing showed that the filtration type of face mask effectively prevents them from spreading far from the wearer.

Cough↗
PubMed1982

Plasma fibrinopeptide A and beta-thromboglobulin in pre-eclampsia and pregnancy hypertension.

Increased plasma levels of beta-thromboglobulin (beta TG) and fibrinopeptide A (FPA), markers of platelet release and thrombin generation respectively, were measured in normal women, women taking oral contraceptives, normal pregnancy and pregnant women with hypertension or pre-eclampsia. No significant increases in beta TG or FPA were found in women taking oral contraceptives. Significantly increased concentrations of beta TG, but not FPA, were found in normal pregnant women in the second and third trimester of pregnancy when compared with non-pregnant age-matched controls. In eleven women with pregnancy hypertension and thirteen women with pre-eclampsia significantly elevated levels of both beta TG and FPA were found when compared with age, parity and gestation-matched pregnant controls. Although the mean value for both beta TG and FPA in the group with pre-eclampsia was higher than the group with pregnancy hypertension, the difference was not statistically significant. These findings provide additional evidence that pre-eclampsia and pregnancy hypertension are associated with activation of the coagulation system and the platelet release reaction.

Beta-Globulins↗
PubMed1978

Staphylococcus aureus sternal osteomyelitis complicating bone marrow aspiration.

This case of S aureus sternal osteomyelitis occurring at the site of bone marrow aspiration in a 24 year-old man illustrates the potential for infection that complicates any clinical procedure, even those considered to have a very minimal risk of infection. The patient recovered uneventfully after antibiotic therapy with nafcillin administered intravenously, followed by dicloxacillin taken orally.

Adult↗