[The action of aurantin on the synthesis of nucleic acids in mouse brain tumors].
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Adenine↗
Biomedical subjects
M Sh Promyslov
Publications and source records attributed to M Sh Promyslov.
[Brain monoamine oxidase in craniocerebral trauma].
Effect of craniocerebral trauma on monoamine oxidase (MAO) activity was studied. The activity of MAO with monoamines as substrates was shown to decrease. In this case transformation of MAO properties was observed: the enzyme exhibited an ability to deaminate di- and polyamines.
Animals↗
[Concentration of glucose in the tissues of glial tumors of the brain in rats with artificial hyperglycemia of short duration].
The glucose content in the tissues of rat brain glial tumors and in the brain tissue during short-term induced hyperglycemia was studied. It was shown that in artificial increase of the concentration of glucose in blood, its content in the tumor grows sharply and exceeds considerably the level of this metabolite in the brain tissue. In distinction from the brain tissue, the tumor was marked by a high rate of glucose consumption and utilization under these conditions. It is concluded that brain glial tumors are also capable of increasing glucose consumption in artificial hyperglycemia. It is suggested the the accumulation of glucose by the tumor creates the preconditions for improving the efficacy of radiotherapy combined with short-term artificial hyperglycemia in the management of brain glial tumors.
Animals↗
[Regulation of the concentration of 1-cystathionine in brain tissue follow craniocerebral injuries].
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Amphetamine↗
[Changes in the cerebrospinal fluid lactate concentration of children with cranio-cerebral injuries].
Examination of the cerebrospinal fluid in 43 children with craniocerebral trauma revealed a dependence of the lactate content on the degree of the injury (9.2 +/- 1.2 mg% in mild trauma; 13.5 +/- 1.7 mg% in moderate trauma; 18.3 +/- 1.7 mg% in severe trauma) and the clinical course. The cerebrospinal fluid is normalized 7-10 days after a moderate brain trauma, and in 3 weeks after a severe trauma. The findings suggest that the values of the cerebrospinal fluid lactate content are lower in children than in adults (9.7 mg%, on the average, in children under 10 years of age, and 11.3 mg% in those over 10 years of age).
Acute Disease↗
[Putrescine and polyamines in human and rat cerebral gliomas].
Content of putrescine was increased and that of spermine unaltered in glioblastomas and dedifferentiated astrocytomas of human brain tissue as well as in the tissue, surrounding the tumors, as compared with the brain tissue. In malignant human glial tumors and in the peritumoral tissue content of spermidine was twice as high as content of the polyamine in grey brain tissue; at the same time, it was decreased 2-fold in the tumors as compared with the white brain tissue. The levels of putrescine, spermidine and spermine were distinctly increased in transplanted glioblastomas of rat brain as well as in the peritumoral tissues.
Animals↗
[Effect of acrylonitrile on gamma-aminobutyric acid levels, glutamate decarboxylase activity, and lipid peroxidation in rat brain].
Acrylonitrile after intraperitoneal administration into rats decreased the content of gamma-aminobutyric (GABA) and inhibited the glutamate decarboxylase activity in brain tissue. Incubation of brain supernatant with acrylonitrile led to stimulation of lipid peroxidation and to a decrease in content of thiols, alpha-Tocopherol prevented the prooxidant effect of acrylonitrile in vitro as well as its effect on glutamate decarboxylase activity and on GABA content in vivo. The neurotoxic effect of acrylonitrile might be related to stimulation of lipid peroxidation.
Acrylonitrile↗
[The induction of lipid peroxidation in human brain glial tumors].
Tissue examinations of glial tumors in the human brain revealed that therein lipid peroxidation could be induced by using bivalent iron salts, which is indicated by higher malonic dialdehyde levels. The authors have demonstrated that the glioma tissue levels of iron were statistically lower than those in the brain tissue. The induction in tumor tissue does not depend upon the degree of its malignancy, but it significantly differs from this parameter in the rabbit brain tissue. The induction of lipid peroxidation processes is accompanied by a lower cumulative antioxidative activity. The findings open new prospects for affecting tumor growth.
Animals↗
[Level of lipid-bound sialic acids in blood from brain tumor patients].
Content of lipid-bound sialic acids was studied in blood serum of patients with benign tumors--gliomas, neurinomas, meningiomas, with malignant tumors--gliomas and anaplasia, glioblastomas, sarcoma, as well as of patients with impairment of peripheral nervous system (without any tumors) and of healthy volunteers. Content of lipid-bound sialic acids in blood serum of patients with benign tumors was similar to that of controls, while it was distinctly increased in all the patients with malignant tumors. These results corresponded to literature data, where the patients with non-brain localization of tumors are considered.
Brain Neoplasms↗
[The antioxidant activity of individual fractions of brain tissue].
The overall antioxidative activity was studied in the rabbit brain homogenate, water-soluble protein and lipid fractions. The antioxidative activity of water-soluble protein fraction made a major contribution to the total activity, while the antioxidative activity estimated by the procedure used was not detected in the lipid fraction. Antioxidant activity both in the brain homogenate and water-soluble protein fraction was similarly altered during craniocerebral trauma and after stimulation of the central nervous system in the injured animals.
Animals↗
[Lipid peroxidation processes and activity of brain succinate dehydrogenase in experimental craniocerebral trauma].
A statistically significant decrease in the activity of succinate dehydrogenase (SDH) was found in the rabbit brain after craniocerebral injury. The decrease in the activity of brain SDH was not shown to result from "competitive inhibition" by malonate accumulated after activation of lipid peroxidation. The activity of brain SDH was normalized by directed modification of the function of the central nervous system via administration of phenamine (amphetamine) into the injured animals.
Animals↗
[Several methodolic features of determining cerebral gamma-aminobutyric acid].
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Aminobutyrates↗
[Characteristics of the level of lipid-bound sialic acids in the blood of patients with brain tumors].
In hemispheric tumors, the highest blood levels of lipid-conjugated acid were found in patients with malignant tumors despite their histology. In the blood of patients with benign tumors of the same site, the content of lipid-conjugated acids was the same as the control ones. However, the blood of patients with chiasmal-cellar tumors did not show these features. The blood level of lipid-conjugated acids in these patients did not depend on tumor histogenesis, but it was generally high. In patients with benign tumours of the chiasmal-cellar region, the levels of lipid-conjugated acids were the same as in patients with malignant hemispheric tumors. This is suggested by the fact that patients with meningiomas or gliomas of the chiasmal-cellar site without anaplastic signs exhibit much higher blood levels of lipid-conjugated acids than those with the similar tumors of the hemispheric site.
Brain Neoplasms↗
[Glycogen degradation in rabbit brain under normal conditions and following cranio-cerebral injury].
Activities of gamma-amylase (acidic alpha-glucosidase) and phosphorylase were studied in brain of normal rabbits and in animals subjected to craniocerebral trauma. The gamma-amylase activity was slightly increased within 10 min after the trauma and its was decreased within 24 hrs. The phosphorylase activity was decreased in the both periods of investigation. Administration of strychnine into normal animals increased the gamma-amylase activity and decreased the phosphorylase activity. At the same time, the normalization of the gamma-amylase activity was observed after stimulation of the central nervous system (by phenamine) of traumatized animals. Inhibition of the central nervous system of traumatized animals (by administration of urethane and barbital mixture) led to the subsequent decrease of the gamma-amylase activity (in several cases up to the zero value) without any alterations in the phosphorylase activity. Participation of gamma-amylase in glycogen metabolism of rabbit brain is discussed.
Amphetamine↗
[Uridine diphosphate sugar in meningiomas of the brain].
The content of uridine-diphosphate (UDP)-saccharides, such as UDP-glucose (UDPG) and UDP-N-acetylglucosamine (UDPAG) was examined in the meningiomas obtained at surgery. Typical, atypical, and anaplastic meningiomas were used. Biochemical data were compared with histological findings. The total level of UDP-saccharides (UDPG + UDPAG) in the meningiomas was demonstrated not to depend on the grade of anaplasia. A positive correlation was found between the UDPG/UDPAG ratio was from 1.73 in typical (benign) neoplasms to 6 or even higher in meningiomas with severe sings of malignancy (anaplastic meningiomas). The UDPG/UDPAG ratio seems to reflect the nature and rate of tumor growth.
Anaplasia↗
[Chemiluminescent study of free radical lipid peroxidation in the rabbit brain after cranio-cerebral trauma].
The method of chemiluminescence was applied for the determination of free radicals content in rabbit brain after the experimental craniocerebral trauma. The level of malondialdehyde was measured spectrophotometrically. The quantity of free radical products in hemispheres, brain stem and cerebellum of rabbits with traumatic injury was shown to be significantly increased and correlated with MDA level. Data obtained indicate that the chemiluminescent technique can be useful for the investigation of lipid peroxidation in brain pathology.
Animals↗
[Assessment of the severity of grave cranio-cerebral injury and its outcome according to the state of energy metabolism in the brain].
A dynamic study of the arteriovenous oxygen and lactic acid content difference, as well as a study of the CSF content of the lactic acid in patients with a severe craniocerebral trauma permitted to evaluate the severity of the pathological process and the results of its treatment. A growing production of lactic acid by the brain and its progressive accumulation in the CSF to a high level as 45-50 mg%, and a sharp dissociation between the increasing lactate level in the CSF and its growing concentration in the venous blood flowing from the brain is a prognostic sign of an unfavourable course and outcome of the disease.
Brain↗
[Study of free radical oxidation of lipids in cerebrospinal fluid of hydrocephalic children].
The levels of free radical production, malondialdehyde concentration and antioxidant activity were estimated in ventricular liquor of the infants with primary hydrocephalus. It was shown that even in the case of uncomplicated hydrocephalus significant disorders in brain metabolism took place. In the patients with inflammatory or hemorrhagic complications the levels of malondialdehyde and free radicals were markedly increased as compared to the infants with "pure" hydrocephalus. The most significant disorders were revealed in the case of hemorrhagic complications. These data indicate the necessity of lipid peroxidation evaluation in liquor of the patients with hydrocephalus and help to workout indications for antioxidants including into the common therapy of this decrease.
Antioxidants↗