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Biomedical subjects

M Seo

Publications and source records attributed to M Seo.

85 records · Page 5Linked to original sources
PubMed1980

Sleep-waking cycle in microencephalic rats induced by prenatal methylazoxymethanol application.

Sleep-wakefulness cycle of adult microencephalic rats due to prenatal administration of methylazoxymethanol (MAM) acetate at the dose of 20 mg/kg on the 15th day of gestation showed no difference from the normal control group, whereas at the dose of 25 mg/kg, %PS and PS/TS decreased significantly. MAM-induced microencephalic rats revealed a significant increase of spindle bursts during PS, suggesting that their PS is less deep than that of the controls.

Animals↗
PubMed1977

Basic experiments with clotrimazole administered orally.

A series of experiments was carried out with the antimycotic agent clotrimazole to establish MICs against a number of different yeasts and to estimate its blood levels following oral administration. Marked differences were noted between the MIC against A and B serotypes of Candida albicans in its yeast-like cell form, that against Type B being nearly 10-times higher than against Type A. Against the mycelial form, however, the MIC was much lower and there was little difference between the levels for the two serotypes. Clotrimazole administered in oral tablet form appeared to be poorly absorbed, little being transferred to the blood. Urinary levels were low and large amounts of the drug were detected in the faeces. Serum levels were below MIC levels in all cases examined. Blood levels 3-times as great as those after the same dosage in tablet form were produced when clotrimazole was given in oil solution and even with 250 mg, effective blood levels were achieved and maintained.

Administration, Oral↗
PubMedDate not supplied

Radiographic findings of intractable gastric ulcers with H2-receptor antagonists.

BACKGROUND: To clarify the radiographic characteristics of intractable gastric ulcers with H2-receptor antagonists. METHODS: The radiographic findings at the time of starting treatment were compared between 42 patients with gastric ulcers that did not heal within eight weeks of starting treatment with H2-receptor antagonists (the intractable group) and 58 patients whose ulcers healed within the eight-week period (the tractable group). RESULTS: The following radiographic findings in the intractable group were observed at a significantly higher incidence than those in the tractable group and included: an ulcer located on the angle, linear ulcers, a greater depth, an uneven mound surrounding an ulcer, prominent folds' convergence, an overhanging gastric mucosa, an irregular ulcer base, a shortening of the lesser curvature and a U-shaped deformity of the angle. A multiple logistic regression analysis showed that the following three factors had a significant and independent delaying effect on healing: a U-shaped deformity of the angle, an uneven mound surrounding an ulcer and prominent folds' convergence. The relative risk of these factors were 12.7, 14.4 and 12.5, respectively. CONCLUSIONS: Intractable gastric ulcer with H2-receptor antagonists can be predicted based on the characteristic radiographic findings at the start of treatment.

Adult↗