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Biomedical subjects

M Semczuk

Publications and source records attributed to M Semczuk.

87 records · Page 5Linked to original sources
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Prolactin and pituitary-gonadal function in cigarette smoking infertile patients.

Serum prolactin (PRL) was significantly lower in smokers, compared with non-smokers in 233 males and 250 females referred to our infertility clinics. In subjects smoking 10 cigarettes or more per day, the mean serum PRL was 22% and 20% lower in men and women, respectively. In cigarette smoking men serum testosterone was significantly higher and semen volume lower, while neither serum luteinizing hormone (LH) or follicle stimulating hormone (FSH), sperm density, motility of morphology differed between smokers and non-smokers. It is possible that the higher serum testosterone levels in smokers are due to their lower bodyweight, and that the lower semen volume may be due to an effect of nicotine on the contractility of the deferental ducts. Cigarette smoking may increase central dopaminergic tonus and reduce PRL levels, but it is unknown whether or not this is of biological significance in relation to reproductive function.

Adult↗
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New data on toxic metal intoxication (Cd, Pb, and Hg in particular) and Mg status during pregnancy.

The technological revolution we witness today poses a threat to the homo sapiens species, and its biological results are unpredictable. Excess toxic metals in the environment and the deficiency of bio-elements are particularly harmful for developing organisms. Long-term fetal exposure during pregnancy to even lower concentrations of toxic metals, which have the ability to accumulate, often leads to irreversible developmental disorders, On the basis of accessible literature, the paper presents transplacental transmission of cadmium, lead and mercury to the fetus. The disadvantageous effects of cadmium and lead on ionic transmission, functional potential and submicroscopic amnion structure as well as the interdependence between the unfavorable effects of these two metals on the amniotic membrane and the competitive antagonistic activity of Mg ions are emphasized. This paper presents a hypothesis suggesting the involvement of cadmium in the etiopathogenesis of eclampsia based on the literature. It also considers the present state of knowledge of the toxic effects of Cd, Pb and Hg on the course of pregnancy and fetal development. Magnesium--an intracellular cation second in importance to potassium plays a significant biological role, though it has not been fully explored yet. The concentration of Mg in the placental and fetal tissues increases during pregnancy. The requirements for this element in a pregnant woman's organism generally exceed its supply; hence, pregnancy should be considered a condition of 'physiological hypomagnesemia'. The accessible data concerning the content of Mg during pregnancy in the blood as well as in the uterine muscular wall in physiological and pathological pregnancies are diverse. The prevailing opinion is that oral supplementation of magnesium during pregnancy makes up for its deficit in the organism of the pregnant woman and also positively influences fetal development. It is recommended to administer magnesium with food in the form of magnesium salts at the dose 5 mg/kg body mass daily. In clinical obstetric practice magnesium therapy is necessary in cases of imminent preterm birth and preeclampsia. This paper discusses the mechanism and therapeutic effectiveness of magnesium sulfate as used in complications of pregnancy. The contamination of the pregnant woman's organism by toxic metals--cadmium, lead and mercury--poses a serious risk of the same quantitative degree of contaminating the organism of the child developing in her womb. Qualitative changes may be much more serious in the fetus as they affect young structures, intensively developing, with no well-formed defense mechanisms. It is also worth mentioning that the complications in the course of pregnancy may result from toxic metal concentrations lower than those leading to fetal necrosis or premature termination of pregnancy.

Female↗
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The effects of beta-adrenergic drugs on the human sperm motility in vitro. II. The effects of isoprenaline and fenoterol.

Thirty semen samples from men with asthenozoospermia were divided into three groups. 0.025 mM of Isoprenaline and 0.65 x 10(-2) mM Fenoterol were added to the first group, a double dose to the second one and five times higher dose to the last one. The lowest concentration used in our experiment results from the applied intravenous therapeutic doses for people. The sperm motility was evaluated under phase-contrast microscope in the 5, 30, 60, 120 and 240 minute of the experiment. The lowest doses of both drugs were most active in relation to the sperm motility in 120 minute after their administration, but the effect appeared to be much higher for Isoprenaline. Isoprenaline resulted in the higher increase of the sperm motility after the addition of the double dose in 240 Minute of the experiment. The effects of the applied B-adrenergic drugs on the sperm motility were discussed.

Adult↗
PubMedDate not supplied

Some aspects of obtaining rat semen by electroejaculation method.

Some physical conditions of the electroejaculation method elaborated by Scott and Dziuk and Kalasiewicz and Wolański have been modyfied. A positive result of ejaculation was obtained in 92.6% of the rats examined when the electric stimuli was applied with the energy of 4--7 times lower than that used by the cited authors. The presented method may prove useful in cases when the same animal is to be used repeatedly.

Animals↗