[Current status of prevention of endogenous affective diseases using lithium].
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Biomedical subjects
Publications and source records attributed to M Schou.
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We have collected information about 118 children born to mothers who were given lithium treatment during the first trimester of pregnancy. The data show that the risk of teratogenic effects is lower than one might have expected from some of the studies carried out on rats and mice; they do not answer the question of whether or not lithium is teratogenic in man. The data were collected retrospectively and therefore overestimate rather than underestimate the risk of teratogenicity.
The renal lithium clearance of a manic-depressive woman rose when she became pregnant and fell to the prepregnancy level when she gave birth. The lithium clearances of four healthy women were higher during pregnancy than after delivery. This emphasizes the need for frequent determinations of the serum lithium concentration and appropriate dosage adjustments during pregnancy and delivery.
Children breast-fed by women on lithium treatment ingested lithium with the milk. Their serum lithium concentration was one-third to one-half the concentration in the nursing women's serum. Bottle-feeding should be considered for children of women on lithium treatment.
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