Search PubMed⌕ Search

Biomedical subjects

M Schmidt

Publications and source records attributed to M Schmidt.

At least 955 records · Page 53Linked to original sources
PubMed1976

[Reduction of smoking hazards by Denicotea filter-cartridges (author's transl)].

In the present study the efficiency of Denicotea filter-cartridges is determined as indicated by change of heart rate, skin temperature, urinary nicotine-content and subjective symptoms. Compared with standard smoking effects the use of Denicotea filters produces smaller increases in heart rate and significant reductions of urinary nicotine-content. The majority of the probands no longer experienced side effects. Thus, the elimination of nicotine from smoke by Denicotea filters is effectively demonstrated. Because only a minority of smokers is actually willing to discontinue their habit, despite medical advice, the introduction of Denicotea filters presents itself as a useful alternative.

Adolescent↗
PubMed1976

[New method of thrombocyte counting. Technic of electronic counting of low thrombocyte concentrations in peripheral blood].

Starting from recent studies of Balleisen (1972) and Schmidt et al. (1973) about automated counting of platelets an automated method has been developed for accurate platelet counting at very low platelet concentration of peripheral blood. The method can be summarized as follows: 0,1 ml anticoagulated venous blood (Na-EDTA or polystyrol tubes containing EDTA powder) or capillary blood from finger tips was diluted with 20 ml of a mixture of Isoton-Periston-(Bayer-)Na2-EDTA (22:2:1 vol.) in polystyrol tubes. After 5 min centrifugation at 85 g, using an angle head and decantation into a polystyrol tube, second centrifugation. Decantation in a Coulter glass and counting at aperture 8, attenuation 0.500 and theshold 6 respectively 70 using at 70 mikron capillary. Counts at threshold 70 (erythrocyte counts) were subtracted from counts at threshold 6 (platelets and erythrocytes); to calculate platelet counts/mm3 multiplication by factor 2 at undiluted venous or capillary blood. The mean variation coefficient of our method being 4,1%, counting of platelets is possible with the accuracy of other automated methods at normal platelet concentration. At very low platelet counts our method seems to be the most accurate laboratory method for platelet counting.

Adolescent↗
PubMed1976

Effects of apomorphine and of pimozide on renin secretion in the anaesthetized dog.

This paper presents the results of a study of the receptors involved in renin hypersecretion induced by dopamine. Apomorphine induces renin hypersecretion without significantly modifying the renal blood flow. This renin hypersecretion is inhibited by haloperidol. However, pimozide, a selective dopaminolytic agent, is incapable of inhibiting the renin hypersecretion induced by dopamine. These results provide supplementary evidence for the existence of renal dopaminergic receptors which would appear to differ from the central dopaminergic receptors.

Animals↗
PubMed1976

Summer day camp for multihandicapped children.

A six-week enriched sensorimotor, communication, and recreational summer day camp for twenty multihandicapped preschool children is described. The program, planned and supervised by therapists and mental retardation counselors, provided training for students who worked as camp counselors. Each counselor was assigned to work with one child and family and was responsible for assessing, establishing goals, designing appropriate programs, attending the child throughout the day, and relating to the family. The camp provided a trial for use of the Functional Skills Profile (FSP), an assessment battery designed by physical and occupational therapists to measure performance changes in low functioning, developmentally handicapped persons in order to determine the value of therapy programs. The camp is evaluated in terms of improvement in the children, the effectiveness of the student training, and parent satisfaction.

Aftercare↗
PubMed1976

Differences between lymphoid cell populations of guinea pigs and mice as determined by the response to mitogens in vitro.

The stimulation of guinea pig lymphocytes by phytohemagglutinin (PHA), concanavalin A (ConA), methanol-extracted residues of tubercle bacilli (MER), purified protein derivative of tubercle bacilli (PPD), dextran sulphate (DS) and E. coli lipopolysaccharide (LPS), was determined and compared with that of mouse lymphoid cells. The sources of lymphocytes tested were spleen, thymus, lymph nodes and bone marrow. The degree of activation of DNA synthesis by PHA and ConA was higher in guinea pig thymocytes and lymph node cells than in corresponding sources of mouse lymphocytes. The optimum degree of stimulation by PHA and ConA was approximately the same in guinea pig thymocytes, while ConA was by far a better stimulator than PHA for mouse thymocytes. All four B-cell mitogens tested (MER, DS, PPD and LPS) activated DNA synthesis in mouse lymphoid cells while only MER and DS were effective in guinea pig lymphocytes. A guinea pig spleen cell population depleted from B cells was not stimulated, neither by DS nor by MER, while it still responded to PHA and ConA. These results indicate that the proliferative response due to MER and DS occurs in the B-cell compartment. It is suggested that the differences between guinea pigs and mice with respect to their ability to develop a cell-mediated type immunity and to respond to T-independent antigens are related to differences in the relative proportions and degrees of maturation of T- and B-cell subpopulations, as reflected by the selective responsiveness to various mitogens.

Animals↗
PubMed1976

[Infrared-spectroscopic studies of the carbonate apatite structure of dental hard tissues].

Samples of enamel, dentine and cementum were calcined at temperatures of 500 degrees C, 800 degrees C and 1000 degrees C. The infrared spectra recorded at these temperatures were evaluated quantitatively and qualitatively. With increasing temperature, the conversion of the primarily present carbonate apatite into hydroxyapatite increased. At 800 degrees C, a hydroxyapatite proportion of 83% was found. At that, the thermal treatment produced in the dentine an increase in the degree of crystallization from 62% to 100%.

Apatites↗
PubMed1976

[The effects of dl-sotalol on the urinary osmolarity of anesthetized dogs].

The effect of dl-sotalol (intrarenal perfusion of 19 mg/kg during 30 min) on urinary concentration was studied under pentobarbital anaesthesia in dehydrated dogs. Sotalol infusion decreased urinary osmolality and increased natriuresis and urine flow. This diuretic action was accompanied by the reduction of the renin hypersecretion elicited by water deprivation.

Animals↗
PubMed1976

[Leptospirosis epidemic (L. grippothyphosa) in the Mainz area, concerning the pediatric age group (author's transl)].

31 children, presenting with rather uncharacteristic symptoms of an infectious disease and being referred to this clinic mostly because of lymphadenitis of the neck (81%) and/or signs of meningitis (45%), were seen within a period of only eight weeks and proved to suffer from Leptospirosis (L. grippotyphosa). The majority of the patients belonged to the age group of one to six years and lived in rural environs. Our observation is considered to relate to a Leptospirosis epidemic and suggests, as opposed to the general acceptance, a much higher incidence of Leptospirosis in this country and, moreover, in children.

Ampicillin↗