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Biomedical subjects

M Schmidt

Publications and source records attributed to M Schmidt.

At least 919 records · Page 51Linked to original sources
PubMed1979

[The value of renal phlebography in the differential diagnosis of arteriographically hypo- or avascular lesions in the kidney (author's transl)].

The present paper is an investigation into the diagnostic value of renal phlebography for differentiating between arteriographically hypo- and avascular malignant lesions in the kidney and benign renal masses. In three examinations carried out on eight patients with renal masses, phlebography was of crucial diagnostic importance. In ten renal cysts a presumptive diagnosis made by arteriography was confirmed by phlebography. In another eight renal cysts, a case of haemorrhagic pyelitis and in two cases of unilateral pseudotumerous pyelonephritis, phlebography was of no value.

Adenocarcinoma↗
PubMed1979

[Rapid determination of antibiotics resistance in clinico-surgical practice on the basis of radioactive carbon dioxide measurements].

The radiometric method is founded on the measurement of the 14CO2 which has gone free. This method was worked out of our team. It is a prompt sensitive and quantitative procedure for the control of antibiotic effect on bacteria. The method is a support in critical clinical situations. The prompt establishment of the antibiotic sensitivity can be live-saving. The empirics descended from 312 surgical patients. The antibiotical sensitivity of secretion samples is to be obtained within 4-6 hours. The results show in comparison with the classic bacteriological examinations five per cent less deviation. At the same time the computer analysis enables a finer distinction. 22 variable findings are possible within the categories: sensible, middling sensible and resistant. In that way the tested antibiotics are classified in an order of rank. The apparatus for the examination is producible without particular expenses. The measurements can be carried out at each hospital or clinical laboratory.

Anti-Bacterial Agents↗
PubMed1979

Effects of a chemotactic factor, N-formylmethionyl peptide, on adherence, superoxide anion generation, phagocytosis, and microtubule assembly of human polymorphonuclear leukocytes.

FMLP promoted microtubule assembly in PMNs at concentrations which were chemotactic for the cells. At higher concentrations than those required for chemotaxis, FMLP enhanced the adherence of PMNs to nylon glass fibers. With colchicine, PMN adherence was inhibited, but upon exposure to FMLP, PMN adherence could be restored. The effect of FMLP on PMN adherence was transitory and was no longer evident by 5 min. At concentrations similar to those employed in the adherence studies. FMLP induced the cells to briefly generate O-2, since ferricytochrome C reduction was no longer evident by 5 min. Pretreatment of the PMNs with cytochalasin B enhanced the release of O-2 by PMNs exposed to FMLP. On the other hand, there was no effect of FMLP on phagocytosis of C3-coated particles. These results suggest that FMLP induces responsive cells to develop a hyperadherent plasma membrane which is largely independent on microtubule control. Since oligopeptides similar of AMLP are formed in bacteria, it is likely that the action of N-formylated peptides is important in regulating the inflammatory response.

Cell Adhesion↗
PubMed1979

Cyclic release of luteinizing hormone and the effects of luteinizing hormone-releasing hormone injection in Asiatic elephants.

Cyclic changes in serum concentration of luteinizing hormone (LH) were observed throughout the estrous cycle of Asiatic elephants (Elephas maximus). The increase in serum LH was correlated with a slight increase in serum estradiol concentration and the onset of behavioral heat (willingness to mate). In a second series of studies, injection of luteinizing hormone-releasing hormone after 3 days of estrone administration induced an increase in serum LH. These studies indicate that the Asiatic elephant exhibits a cyclic LH release that can be experimentally induced by estrone and luteinizing hormone-releasing hormone administration.

Animals↗
PubMed1979

[Determination of serum digoxin. A comparison between RIA and EIA (author's transl)].

The results of two radioimmunoassays (RIA, precipitating technique), of a homogenous (EMIT) and a heterogenous (ELISA) enzyme immunoassay (EIA) for ascertaining the amounts of digoxin showed a good correlation in precision and a reasonably satisfying correlation in the recovery. However, there was a clear discrepancy in the amounts of digoxin concentrate in the serum of patients. Only the RIA of Abbott and the EIA of Boehringer showed no significant differences. Particularly noticeable was the tendency towards lower values in the EMIT-technique as well as its liability to unspecific serum changes (lipaemia etc.), which often made the detection of digoxin impossible. The routine use of this technique appears problematic. The need for establishing one's own laboratory and test-specific therapeutical range is pointed out.

Digoxin↗
PubMed1978

Reactivity patterns of nerve cell-glia-complexes in mice during pentylenetrazole-induced seizures. Cytometric-cytophotometric studies.

The relationships between nerve cell-glia-complexes (NGCs) and surrounding capillaries were studied by combined cytometric-cytophotometric methods in male mice up to 60 min after injection of 70 milligrams/kilograms of pentylenetetrazole (PTZ). The nuclear area in neurons from cortical layers IV and V of the motoric area 8 increased by 13%, and in neurons from the hypoglossal nucleus there was an increase of 23%, associated with phasic changes in the nuclear area of their glial satellites. The number of perfused capillaries increased in both brain regions and there was a 20%-elongation of erythrocyte-filled capillary segments. The cytoplasmic RNA content enlarged in the hypoglossal neurons but decreased in cortical neurons from area 8. Peptidergic neurons and their glial satellites (supraoptic nucleus) showed nuclear shrinkage. Fifty percent of these peptidergic neurons reacted by reduction of their cytoplasmic RNA content. The measured cell reactions seem to be specific for different groups of NGCs which were defined by their histotopography, their neuronal interconnections, and a prevalence of secretory or nonsecretory neurons.

Animals↗
PubMed1978

[Treatment of metastasising soft-tissue sarcoma with a uniform combination chemotherapy of cyclosphosphamide, vincristin, adriamycin and DTIC ("CyVADIC") (author's transl)].

Combination chremotherapy with cyclophosphamide, vincristin, adriamycin and DTIC (CyVADIC") was used from 1974 to the middle of 1977 on 12 patients with various forms of metastisising soft-tissue sarcoma. An objective response was observed in seven of eleven patients. Full, although brief, remission occurred in two of six patients with fibrosarcoma and persists in one with an undifferentiated sarcoma. Partial remission was induced in one patients each with fibrosarcoma and alveolar-cell sarcoma. Mean survival time was 18 months. Those responding to treatment had a longer average survival time than those refractory to it. No statistically significant conclusions can be drawn because of the small number of patients, but these observations suggest that this combined treatment can favourable influence previously therapy-refractory forms of metastasising soft-tissue sarcoma.

Adult↗
PubMed1978

Intrarenal control of urine concentration by angiotensin II.

1. The intrarenal role of angiotensin II in the recovery of urinary concentration after frusemide was examined in anaesthetized dogs by the intrarenal infusion of angiotensin II antagonists. 2. Renin secretion and renal inner medullary blood flow (tissue clearance of intraparenchymatously injected 133Xenon) were simultaneously measured before and 3 h after frusemide injection. 3. Intrarenal angiotensin II blockade delayed the recovery of urinary osmolality after frusemide. 4. An inverse relationship was found between renin secretion and renal inner medullary blood flow.

Angiotensin II↗
PubMed1978

[Fibrous cortical defects (author's transl)].

During a period of two and a half years, twelve fibrous cortical defects were discovered as incidental findings. With the exception of two cases, the radiological findings remained unchanged during the period of observation. One large defect extending into the diaphysis was submitted to surgery and verified histologically. The characteristic radiological appearances and the differential diagnosis from similar looking benign and malignant bone abnormalities are discussed and compared with the findings of other authors.

Adolescent↗
PubMed1978

[Discoid meniscus (author's transl)].

The discoid meniscus is a developmental varient which can produce symptoms resembling those of a meniscus lesion. Two cases are described and the literature is reviewed. The clinical features, diagnosis, pathogenesis and treatment of discoid meniscus is discussed.

Adolescent↗
PubMed1978

[The effect of iodine-containing radiographic contrast medium on TSH-TRH-tests (author's transl)].

In the course of an investigation of TRH-tests, 340 TSH-tests were performed in 120 patients before and after the administration of various iodine-containing radiographic contrast media in order to determine a possible effect on the TRH-tests. In addition, the peripheral thyroxin level and RIA-T3 content of the serum was determined. Mean TSH rise following TRH (delta-TSH) showed no significant difference before and after the contrast medium. Individual variations were, however, observed. In view of these results, it is concluded that the TRH-test provides reliable information after iodine exposure.

Contrast Media↗