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Biomedical subjects

M Schmidt

Publications and source records attributed to M Schmidt.

At least 883 records · Page 49Linked to original sources
PubMed1981

Lymphoplasmacytic/lymphoplasmacytoid lymphoma: a clinical entity distinct from chronic lymphocytic leukaemia?

Clinical data of 116 patients with chronic lymphocytic leukaemia (CLL) and of 114 patients with lymphoplasmacytic/lymphoplasmacytoid lymphoma (synonym: LP immunocytoma, IC) as diagnosed according to the Kiel classification were compared. This interim evaluation of a prospective multicenter study of the Kiel Lymphoma Study Group characterizes IC the less favorable lymphoma entity as evidenced by a more rapid lymph node enlargement, by a higher incidence of constitutional symptoms and of marked anaemia, and by a higher percentage of patients requiring early treatment. In addition, in IC autoimmune haemolytic anaemia was detected in 11.2% of investigated patients as compared to none of the patients with CLL, and monoclonal gammopathy was disclosed in 34.2% of investigated patients as compared to only three patients with CLL who could be, however, unrecognized cases of IC. Actuarial survival data after a follow-up period of 40 months are in favor of an overall better prognosis of patients with CLL than of patients with IC.

Adult↗
PubMed1981

Germinal center cell lymphomas: prognostic significance of their histopathological differentiation.

Clinical data of 48 patients with centrocytic, 83 patients with centroblastic/centrocytic and 64 patients with centroblastic lymphoma who had entered a prospective multicenter study of the Kiel Lymphoma Study Group since October 1975 were compared. Advanced (stage IV) disease at time of diagnosis, predominantly due to bone marrow infiltration, was most frequent in centrocytic (69% of patients) and in centroblastic/centrocytic (51% of patients) lymphomas as compared to only 28% of patients with centroblastic lymphoma. High survival probability of patients with localized centrocytic and centroblastic/centrocytic lymphomas after radiotherapy, contrasting with a worse prognosis of corresponding patients with centroblastic lymphoma, is compatible with the classification of these lymphoma entities as neoplasias of low-grade malignancy. However, as shown by this prospective and previous retrospective trials overall survival probability of patients with advanced centrocytic lymphoma was inferior to that observed in corresponding patients with centroblastic/centrocytic lymphoma. These findings suggest the possibility that patients with advanced centrocytic lymphoma occupy an intermediate position between typical low-grade and typical high-grade malignant non-Hodgkin lymphomas.

Adult↗
PubMed1981

Clinical and prognostic heterogeneity of non-Hodgkin lymphomas of high-grade malignancy.

Comparison of clinical data of 64 patients with centroblastic lymphoma, 55 patients with immunoblastic lymphoma and 31 patients with lymphoblastic lymphoma not only confirmed the original assumption of high-grade malignancy as proposed by the concept of the Kiel classification but also demonstrated distinct clinical differences, particularly between lymphoblastic lymphoma and the two other entities. Rapid lymph node enlargement as well as steep fall of survival curves within the first year after diagnosis were common characteristics. Bimodal age distribution, predominance of males and early generalization of disease were typical features of lymphoblastic lymphoma; elderly patients and patients with the unclassified subtypes of lymphoblastic lymphoma exhibited the worst prognosis. Whereas patients with centroblastic and immunoblastic lymphomas showed similar distribution of age, sex and initial stage of disease, patients with immunoblastic lymphoma presented more frequently with a reduced performance status and showed a poorer response to radio- and chemotherapy resulting in a worse prognosis discernible after the first year of follow-up. Generalization during course of the disease was significantly more frequent in immunoblastic than in centroblastic lymphoma.

Adolescent↗
PubMed1981

The carotid bodies of spontaneously hypertensive rats (SHR): a functional and morphologic study.

The parameters of the acid-base-state of the arterial blood were measured in spontaneously hypertensive rats of the Okamoto-strain (SHR) and in normotensive Wistar rats (NWR) of a random-bred strain. The animals were anaesthetized with chloralose-urethane and breathed normal air under sea-level conditions. Structure and size of their carotid bodies were studied by light-microscopic methods. When compared with the NWR, the SHR showed a respiratory alkalosis and enlarged carotid bodies. In the SHR, never in the NWR, the lumen of the branches of the glomic arteries was narrowed by pad-like structures. The data suggest that systemic hypertension leads to morphologically and functionally detectable alterations of both carotid body structure and function. The interdependence of arterial chemoreceptor activity, sodium household, and the adjustment of systemic arterial blood pressure is briefly discussed.

Animals↗
PubMed1981

[Effect of propranolol on diuretic activity of furosemide hypertensive patients (author's transl)].

The effect of propranolol on water and sodium depletion provoked by frusemide was studied. Nine hypertensive patients were treated at 2-day intervals with a single dose of 40 mg of frusemide associated with a placebo or propranolol (320 mg given in 8 doses over a period of 24 hours). The association frusemide-propranolol is more hypotensive than frusemide alone. Propranolol reduced the rise in plasma renin activity and aldosteronuria provoked by the diuretic; total sodium output/24 h remained stable but sodium elimination was increased in the later samples. This prolongation of the natriuretic action is correlated with the inhibition of hyperaldosteronuria. Propranolol depresses urinary osmolality for a longer period than frusemide alone and water elimination tends to be higher. This action of the beta-blocker on urine concentration is independent of its effects on aldosteronuria but is correlated with the inhibition of the rise in plasma renin activity.

Aldosterone↗
PubMed1981

[Thrombolytic therapy in a case of mitral valve thrombosis (author's transl)].

In this paper we present a case in which thrombolytic treatment with Streptokinase was successful in a 53-year-old patient, who developed valve thrombosis one year after aortic and mitral-valve replacement by Björk-Shiley tilding-disk-valve prosthesis. The patient suffered from pulmonary congestion and cardiogenic shock. In spite of Arterenol infusion the blood pressure fell down to 90/50 mm Hg. The systolic pulmonary artery-pressure rose up to 120 mm Hg, the cardiac output was 1.8 l/min. The patient became anuric. A transport to the next department of cardiovascular surgery was impossible. In this extraordinary critical situation for the patient we introduced a thrombolytic therapy with Streptokinase. Within a few hours, the systolic pulmonary artery-pressure fell down by 33%, the cardiac output increased by 100%. One and half days later the patient did not need Arterenol infusion and the blood pressure was 120/80 mm Hg. Referring to this observation, we conclude that Streptokinase therapy can be a successful emergency-treatment of a life-threatening artificial heart-valve thrombosis, if surgical treatment is impossible.

Female↗
PubMed1981

The carotid bodies in spontaneously hypertensive (SHR) and normotensive rats--a study concerning size, location and blood supply.

Size, anatomical position and blood supply of the carotid bodies were studied by light microscopic methods in spontaneously hypertensive rats of the Okamoto-strain (SHR) and in normotensive Wistar rats (NWR) of a random-bred strain. In both groups of animals the single carotid body was usually supplied by only one glomic artery which most frequently derived from the external carotid artery, more rarely from the occipital artery and very seldom from the internal carotid artery. In general the carotid bodies were of ellipsoide shape and compact structure and as a rule closely located to the internal carotid artery. In the NWR at the origins of their glomic arteries almost regularly circular intraarterial cushions were found; in the SHR such cushions were only seen in a few cases, and if so than they were less clearly developed. In the SHR, never in the NWR, within the carotid body the lumen of some branches of the glomic arteries was narrowed by pad-like structures. When compared with the NWR the SHR showed enlarged carotid bodies and a respiratory alcalosis, suggesting that systemic hypertension leads to morphologically and functionally detectable alterations of both carotid body structure and function.

Animals↗
PubMed1980

[Case of carbamazepine-induced interstitial pneumonia].

Report on a case of a woman suffering from trifacial neuralgia who was treated with Carbamazepin (Tegretal). Following therapy there occured dyspnea and cough, followed by a considerable reduction of the pulmonary function. The symptoms were caused by a probably allergic interstitial pneumonia induced by Carbamazepin. The onnexion between Carbamazepin and respiratory failure could be established by reexposition. This side-effect of Carbamazepin is a very rare event.

Carbamazepine↗
PubMed1980

Two phases of DNA replication in human cells.

The course of DNA synthesis in the chromosomes was studied in synchronized human lymphocyte cultures, by means of the BrdU-Hoechst-Giemsa method. In comparing replication patterns and G-banding it was found that with regard to banding the process of DNA replication can be divided into two separate phases, an "early replication period" which is characterized by DNA synthesis in R bands of the autosomes and active X chromosome, and a "late replication period" which concerns the G-positive regions of the autosomes and all the bands of the heterochromatic X and Y chromosomes. No overlapping was found between the two phases mentioned. The possible role of regulatory mechanisms was discussed.

Cell Cycle↗
PubMed1980

Investigations of thallium-exposed workers in cement factories.

Thallium and its compounds have a high toxic potency. For the production of particularly resistant sorts of cement, additives containing thallium, among other things, are employed. In conformity with our present toxicological knowledge, the determination of the concentration of thallium in the urine must be considered a suitable parameter for the assessment of the presence of thallium in the body. Occupational-medical preventive examinations were carried out in a total of 128 male employees from all areas of production in three cement factories. An exposure of these employees to thallium was objectified by analyses of the roasted pyrites employed and the dust from the electric filter. The study included the questioning of the employees with respect to their previous history of health, and also a physical examination aimed at detecting clinical symptoms of a possible effect of thallium. The analysis of thallium was carried out in samples of "spontaneous" urine. The analytical method employed was flameless atomic absorption spectroscopy (carbon-rod atomizer). In part, the group of persons investigated revealed excretions of thallium slightly or moderately above the normal level (range: < 0.3-6.3 micrograms/g creatinine). As the upper normal limit of thallium excretion, we computed a value of 1.1 micrograms/g creatinine. In no case, however, did the case history data or the findings of the physical examination reveal any indication of the symptoms characteristic of thallium poisoning.

Adolescent↗