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Biomedical subjects

M Schachter

Publications and source records attributed to M Schachter.

At least 199 records · Page 11Linked to original sources
PubMed1979

Mazindol in the treatment of narcolepsy.

Thirty-four subjects with the narcoleptic syndrome were treated with mazindol 3--8 mg daily for 1 year. Treatment cuased a sustained improvement in narcolepsy, but had no effect on cataplexy or sleep paralysis. The response to mazindol was excellent in six subjects, good in 14, moderate in 12 and poor in two. No cardiovascular effects, haematological toxicity, tolerance or dependence occurred. Mazindol 6 mg had the same effect on narcolepsy as d-amphetamine 50 mg, but caused less side effects.

Adolescent↗
PubMed1978

Studies on kallikrein in the duct systems of the salivary glands of the cat.

By correlating immunofluorescence light microscopy with electron microscope studies and with kallikrein concentrations under various conditions, we have made the following observations and conclusions about kallikrein in the submandibular and other salivary glands.1. In the submandibular gland, specific immunofluorescence to kallikrein was observed in the luminal region of the striated ducts particularly, but also in the outer epithelial cells of the stratified epithelial collecting ducts. Sympathetic nerve stimulation resulted in a reduction in intensity of specific fluorescence and in its increased localization towards the lumen. The nearly complete elimination of kallikrein from the gland by duct obstruction for four days resulted in complete disappearance of specific fluorescence in the gland. Prolonged parasympathetic nerve stimulation at frequencies which did not reduce the kallikrein concentration of the gland failed to alter the specific immunofluorescence despite copious secretion of saliva. Our results failed to reveal evidence of secretion of kallikrein either into or towards the interstitium of the gland. The luminal layer of stratified epithelial cells in the collecting ducts contained small secretory granules closely resembling those in the striated ducts. Our results are not conclusive, but do suggest that kallikrein is located in these granules whence it is secreted into the lumen of the duct.2. The parotid gland was found to contain much lower concentrations of kallikrein than the submandibular gland. This finding was associated with the presence of far fewer striated ducts in the parotid gland. Otherwise, specific fluorescence and the response to sympathetic nerve stimulation was like that of the submandibular gland. Small secretory granules in the striated and collecting ducts resembled those of the submandibular gland.3. The sublingual gland, like the parotid, had a low concentration of kallikrein and very few striated ducts. These ducts were unevenly distributed and were concentrated in only a few lobules of the gland. Specific immunofluorescence was seen only in sections containing striated ducts.4. The possible physiological role of kallikrein in the salivary glands is discussed.

Animals↗
PubMed1978

Improved results in combination chemotherapy of head and neck cancer using a kinetically-based approach: a randomised study with and without adriamycin.

One hundred and seventeen patients with advanced squamous cell carcinoma of the head and neck were randomised between two combination schedules, one with and the other without adramycin. Responses (more than 50% tumor regression) were 67% overall with 63% responding to the combination without adriamycin and 82% responding to the schedule containing it. The increase in response rate seen with the addition of adriamycin is not statistically significant. Prior radiotherapy reduced the likelihood of response to chemotherapy.

Antineoplastic Agents↗
PubMed1978

Localization of kallikrein in the coagulating and submandibular glands of the guinea pig.

Antibody to pure kallikrein from the coagulating gland of the guinea pig was used to localize kallikrein in the gland by immunofluorescence techniques. This antibody also reacted with the guinea pig's submandibular gland kallikrein. The specific fluorescence in the coagulating gland was present diffusely in all secretory cells lining the crypts. In contrast to its diffuse location in the coagulating gland, kallikrein in the submandibular gland was specifically located in the luminal border of striated and some larger duct cells, whereas the acinar cells and interstitial tissue showed no significant fluorescence.

Animals↗
PubMed1978

[Not Available].

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History, Modern 1601-↗
PubMed1977

Effect of nerve stimulation, denervation, and duct ligation, on kallikrein content and duct cell granules of the cat's submandibular gland.

Various procedures which reduce or deplete the kallikrein content of the cat's submandibular gland correspondingly reduce the number of apical granules in the striated duct cells. The kallikrein content is greatly reduced after chronic parasympathetic but not after sympathetic nerve section which suggests that the parasympathetic innervation is required for synthesis or storage of this enzyme.

Animals↗
PubMed1977

Direct evidence for the location of kallikrein in the striated ducts of the cat's submandibular gland by the use of specific antibody.

Kallikrein was located in the apical portion of the striated duct cells of the cat's submandibular gland by an immunohistochemical technique. This portion only of these cells showed an intense band of specific fluorescence. There was no evidence of specific fluorescence in the acinar and demilune cells nor in the interstitial tissue or blood besells. In some sections the collecting ducts showed a very fine fluorescent luminal rim.

Animals↗
PubMed1977

[Erotomania or the delusional conviction of being loved. Contribution to the psychopathology of the love life].

Identified and described 150 years ago, the delirious conviction of being loved, or erotomania, is probably more frequent (in his less spectacular forms) in the private practice, than in the psychiatric services. The critical examination of the literature permits to classify this peculiar clinical-psychological entity as paranoid psychoses, or as sensitive characteropathias of the the Kretschmer-type, finally as an exaggerated-rediculous form of the intra-specific struggle for the conquest of a sexual partner. The pathogenesis of erotomania is yet under discussion. The psycho-analytic conception invoking the rejection or denegation of a latent homosexuality is yet not demonstrated. Six personal cases (three women, two of them being married, and three single men) are related as a contribution to the study of the yet debated problem of erotomania.

Adolescent↗