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Biomedical subjects

M Satoh

Publications and source records attributed to M Satoh.

At least 1,189 records · Page 66Linked to original sources
PubMed1978

[A statistical survey of autopsy cases of malignant goiter (author's transl)].

A total of 747 cases of malignant neoplasms of the thyroid reported in the "Annual of the Pathological Autopsy Cases in Japan" during the past 5 years (1969 approximately 1973) were reviewed and statistically analysed. Histological diagnosis in this series were papillary carcinoma in 323 cases (51.8%), follicular carcinoma in 143 cases (22.9%) and anaplastic carcinoma in 102 cases (16.3%). The average age of patients at autopsy was 58 years for papillary carcinoma cases, 62.4 years for follicular carcinoma cases and 61.7 years for anaplastic carcinoma cases. The incidence of metastatsis to lymph nodes and to organs was 47.3% and 51.5%, respectively in cases of follicular carcinoma and 73.3% and 98.0%, respectively in cases of anaplastic carcinoma. Autopsy revealed an otherwise unnoticed thyroid cancer in 457 cases, which accounted for 61.2% of the entire autopsy cases of malignancy of this organ. A so-called multiple cancer, i.e. the concurrence of carcinomas in the thyroid gland and other organs, was seen in 239 cases (32.3%).

Adenocarcinoma↗
PubMed1978

Analgesia by enkephalins injected into the nucleus reticularis gigantocellularis of rat medulla oblongata.

Methionine-enkephalin (0.2--20 microgram/rat) and leucine-enkephalin (1--20 microgram/rat) produced a dose-related and naloxone-antagonizable analgesia in the tail-pinch test, when microinjected into the nucleus reticularis gigantocellularis (NRGC) and nucleus reticularis paragigantocellularis (NRPG) of the medulla oblongata of the rat. The median analgesic doses were 1.4 and 4.8 microgram/rat for methionine- leucine-enkephalin, respectively. The possibility that the endogenous enkephalins play a part as pain control substances or modulators in the NRGC and NRPG was discussed.

Analgesics↗
PubMed1978

Tracheal constriction by morphine and by fentanyl in man.

The effects of morphine and fentanyl on tracheal smooth muscle tone were studied in 38 patients during induction of anesthesia. Endotracheal tube cuff pressure was used to measure tracheal tone. Anesthesia was maintained with nitrous oxide, 70 per cent in oxygen, and pancuronium and ventilation was controlled with a respirator. Morphine, 0.5 mg/kg, produced a biphasic response, initially causing tracheal dilatation and then tracheal constriction. Ten minutes after morphine injection, cuff pressure increased to significantly (21 +/- 8 per cent) above control. Morphine-induced tracheal constriction could be completely blocked by the prior administration of atropine, 0.5 mg. Fentanyl, 0.006 mg/kg, also produced significant tracheal constriction, cuff pressures increasing to 44 +/- 11 per cent above control at 10 min. Fentanyl-induced tracheal constriction could be blocked by pretreatment with droperidol, 0.25 mg/kg. At equianalgesic doses, morphine and fentanyl produced similar tracheal constriction.

Adult↗
PubMed1978

Association of serum antithyroid antibodies with lymphocytic infiltration of the thyroid gland: studies of seventy autopsied cases.

Postmortem histological examination of the thyroid gland and measurement of serum antithyroid antibodies were performed in 70 patients without overt thyroid disease. Lymphocytic infiltration, antithyroglobulin hemagglutination antibody (TGHA), and antithyroid microsomal hemagglutination antibody (MCHA) were found in 12, 2, and 9 cases, respectively. The incidence of lymphocytic infiltration in females was three times that in males. Ten of the 12 cases with lymphocytic infiltration had positive antibodies (either TGHA or MCHA), while 10 of 11 patients with positive antibodies showed lymphocytic infiltration. Thus, the correlation between morphological and serological findings was highly significant at P less than 0.001. The incidence of a small thyroid gland of less than 15 g in weight was higher in patients with lymphocytic infiltration and/or positive antibodies than in patients with a normal thyroid gland. These data suggest that positive serum antithyroid antibodies in subjects without overt thyroid disease may indicate the existence of lymphocytic infiltration in the thyroid gland, that is presumably subclinical autoimmune thyroiditis.

Adult↗
PubMed1978

Droperidol, its alpha-adrenergic blocking action on the aortic strip and inhibitory action on norepinephrine uptake of the adrenergic terminal of the left atrial strip of rabbit.

In aortic strips, the dose-response curves for phenylephrine were obtained before and after addition of droperidol. Droperidol caused a parallel shift of the curves dose-dependently toward the right side and its grade of the shift was greater than caused by phentolamine at the same concentration. In the left atrial strip, the potentiation of contraction by tyramine was markedly depressed by droperidol. In the reserpinized preparation, the effect of tyramine was depressed markedly and there was no norepinephrine fluorescence. After incubation with norepinephrine they were restored to the same level as in non-reserpinized preparations. However, incubation with droperidol before norepinephrine blocked the restoration. It is postulated that droperidol may have both alpha-adrenergic blocking action and inhibitory action on norepinephrine uptake by adrenergic terminals.

Adrenergic alpha-Antagonists↗
PubMed1977

Neuronal aspects of opiate dependence and tolerance in comparison to central depressants.

Some acute and chronic effects of opiates and of central depressants have been reviewed, in order that a comparison can be made between the actions of these drugs. Special emphasis has been given to opiate-induced changes at the neuronal level, which have been studied either by the direct microelectrophoretic application of drugs to single neurones or by application of drugs to the myenteric plexus/longitudinal muscle preparation of the guinea pig ileum. Available evidence suggests that chronic exposure of nervous tissue to opiates as well as to central depressants causes changes in neuronal excitability, which become apparent upon withdrawal of the drug. Although opiates and central depressants cause similar changes they appear to do so by different mechanisms. Such differences between the mode of action of opiates and central depressants may provide an explanation for the differing chronic effects of these drugs.

Animals↗
PubMed1977

Two cases of nevoid basal cell carcinoma syndrome.

Two cases of nevoid basal cell carcinoma syndrome were reported with a review of pertinent literature. The first case was a 59-year-old man, whose autopsy was warranted. Signs and symptoms manifested in this case were basal cell carcinoma, generalized multiple nevi, multiple cysts in the jaws and long bones, pits in the palm and sole, frontal and occipital bossing, ossification of the falx cerebri, a bifid rib, renal fibroma and a patent foramen ovale. The family history revealed a hereditary predisposition as to the syndrome. The patient in the second case included basal cell carcinoma, multiple nevi, multiple jaw cysts, pits in the palm and sole, frontal bossing, calcification of the falx cerebri, cervical vertebral fusion and high-arched palate.

Adult↗
PubMed1976

Actions of opiates upon single unit activity in the cortex of naive and tolerant rats.

The effect of microelectrophoretically and systemically applied opiates on neuronal discharge activity in the sensorimotor cortex of naive and morphine tolerant/dependent rats has been studied. In naive rats depression of spontaneous discharge activity was the predominant effect of low doses of phoretically applied morphine. Higher doses and repeated application frequently converted this effect into excitation. Only the depressant effect was antagonised by naloxone. Naloxone itself had no effect on spontaneous discharge activity when applied at dose-levels sufficient to antagonise the depressant effect of morphine. Levorphanol mimicked the action of morphine whereas dextrorphan was inactive. Morphine depressed the excitatory action of L-glutamate and of acetylcholine by a naloxone-antagonisable mechanism. Systemic application of Fentanyl mimicked the inhibitory effect of phoretically applied morphine upon transcallosally evoked discharge activity. The late response was markedly depressed whereas the primary response was little affected. Phoretically applied naloxone antagonised the effects of systemically applied Fentanyl. In chronically morphinised rats the depressant effect of microelectrophoretically administered morphine was almost lacking and a naloxone-resistant excitation became the predominant effect. In these animals the excitant effect of naloxone was also increased and the anti-glutamate effect and the anti-acetylcholine effect of morphine was abolished. The present data speak in favour of a postsynaptically located stereospecific receptor which mediates the inhibitory effects of opiates and which may be involved in the development of acute and chronic tolerance to these drugs.

Acetylcholine↗
PubMed1976

[Dense material observed in pericapillary space of the thyroid of Hashimoto's disease].

An electron microscopic observation was performed on the follicular capillary of thyroid of Hashimoto's disease. Material was the thyroid obtained from a 41-years-old female showing typical features of this disease both clinically and histologically. Some remarkable findings were the presence of multi-layered basement membrane like structure, and the accumulation of dense minute granular materials concerning with long processes of lymphcyte in the widened pericapillary space. From the above-mentioned findings, it was postulated that there was abnormal transport on follicular basement membrane-pericapillary space-endothelial basement membrane system.

Adult↗
PubMed1976

Supersensitivity of cortical neurones of the rat to acetylcholine and L-glutamate following chronic morphine treatment.

the effect of microelectrophoretically applied L-glutamate and acetylcholine on discharge activity of cortical neurones was studied in naive and in morphine-tolerant/dependent rats. The thresholds for increase in discharge activity elicited by these 2 putative neurotransmitters were 3 times lower in the tolerant/dependent rats than in the naive rats, indicating the development of supersensitivity.

Acetylcholine↗
PubMed1976

Ultrastructure of the giant cell in de Quervain's subacute thyroiditis.

The author made an electron microscopic observation on multinucleated giant cells which appear in the thyroid gland in subacute thyroiditis (de Quervain). Numerous typical desmosomes, which intermingled with myriad of mitochondria and small electron dense granules, were found in the cytoplasm of giant cell. Desmosome is one peculiar to the intercellular junction of follicular epithelium of the thyroid gland, and the fact that many desmosomes were found in the cytoplasm is one of the proofs showing this giant cell to be possibly derived from the follicular epithelium.

Adult↗
PubMed1976

Effects of indomethacin and the other anti-inflammatory agents on activation of dorsal horn cell in the spinal cord induced by intra-arterial injection of bradykinin.

Bradykinin (1-2 mug) injected into the femoral artery of the rabbit induced a marked increase in the firing rates of the dorsal horn cells (lamina V cells). This response was markedly inhibited by intravenous administration of indomethacin (1.0 mg/kg), acetylsalicyclic acid (20 mg/kg), aminopyrine (50 mg/kg) and oxyphenbutazone (20 mg/kg) in both intact and spinal preparations. Moreover, the intra-arterial injection of these agents depressed the response in lower doses. With these same low doses, no significant suppression occurred when the intravenous route was used. These results indicate that indomethacin and other anti-inflammatory agents tested suppress the bradykinin-induced response of the dorsal horn cell at the periphery, probably at the paravascular sensory nerve.

Animals↗
PubMed1976

Inhibition of thalamic and hypothalamic somatosensory evoked potentials by stimulation of substantia nigra and its modification by morphine and methotrimeprazine (levomepromazine).

A brief electrical stimulation of the substantia nigra induced a marked and long lasting inhibition of the somatosensory evoked potentials recorded from the centrum medianum of the thalamus (CM) and posterior hypothalamic area (PHA) following sciatic stimulation in unanesthetized rabbits. The nigral inhibitory effect on CM was prolonged by the administration of morphine (4 mg/kg i.v.) but not influenced by that of methotrimeprazine (2-4 mg/kg i.v.). In contrast, the nigral inhibitory effect on PHA was enhanced by the injection of methotrimeprazine (2 mg/kg i.v.), but not changed by that of morphine (4 mg/kg i.v.). These results indicate that the inhibitory system originating from the substantia nigra operates on the somatosensory transmissions from the peripheral nerve to the thalamus and hypothalamus, and that morphine or methotrimeprazine in small doses induced a selective potentiation of the nigral inhibitory influence on the thalamus or hypothalamus, respectively.

Animals↗
PubMed1976

Indirect and direct depressive effects of morphine on activation of lamina V cell of the spinal dorsal horn induced by intra-arterial injection of bradykinin.

Small doses of morphine (0.3-2.0 mg/kg i.v.) inhibited, in the majority of intact rabbits, the unitary activities of the lumbar lamina V dorsal horn neurons induced by intra-arterial injection of bradykinin, a potent pain producing substance, but not in spinal rabbits. A large dose of morphine (5.0 mg/kg), however, inhibited the bradykinin-induced response even in spinal rabbits. These results suggest that morphine, in small doses, inhibits the sensory transmission of bradykinin-induced pain at the dorsal horn of the spinal cord, through its facilitatory action on the descending inhibitory mechanism; in large doses the level of dorsal horn is directly inhibited.

Animals↗