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Biomedical subjects

M Sas

Publications and source records attributed to M Sas.

At least 37 records · Page 2Linked to original sources
PubMed1987

The modulating effect of estrogens on luteinizing hormone release in complete androgen insensitivity syndrome before and after gonadectomy and cyclic steroid application.

The response of LH release to exogenous estrogens was studied in three patients with androgen insensitivity syndrome (AIS) before and after gonadectomy and a prolonged treatment with a sequential pill. Estrogen provocation tests were performed in which 0.05 mg/kg body weight estradiol benzoate was administered intramuscularly and serum FSH and LH levels were assessed every 12 hours for 96 hours after gonadectomy, three months after a prolonged treatment with a sequential pill (16 cycles: 9 days mestranol 100 micrograms, 12 days mestranol 80 micrograms and chlormadinone acetate 2 mg) and in one patient before gonadectomy. The control group consisted of 10 normal females during the follicular phase. A positive feedback effect was induced in normal females and in AIS patients after prolonged treatment with a sequential pill.

Adolescent↗
PubMed1986

An investigation on the influence of steroidal contraceptives on milk lipid and fatty acids in Hungary and Thailand. WHO Special Programme of Research, Development and Research Training in Human Reproduction. Task Force on oral contraceptives.

A double-blind clinical trial to examine the effects of oral and long-acting injectable contraceptive steroids on milk lipid and its fatty acid content has been done in Szeged, Hungary, and Khon-Kaen, Thailand. In Szeged, a combined and a progestin-only pill did not significantly alter total milk lipid. In Khon-Kaen, treatment with the combined pill was followed by a significant increase in the proportion of milk lipid. In the group treated with the long-acting injectable contraceptive, depot-medroxyprogesterone acetate (DMPA), the milk lipid decreased significantly in the first six weeks in comparison with the control group and the individual pretreatment values. A similar but weaker effect was noticed with the progestin-only pill in Khon-Kaen. Few consistently significant differences were found in the shorter chain fatty acids (myristic, lauric and palmitic acids) during treatment. The percentage proportions were increased during the combined pill treatment in Szeged and Khon-Kaen, and reduced in DMPA and progestin-only treatment in Khon-Kaen milks. The possibility that these reflected a response to a milk volume decrease in the combined pill treatment and a reduction in milk lipid synthesis in association with DMPA and the progestin-only pill is discussed. In Khon-Kaen, linoleic acid (which is not synthesized in the body) was increased by comparison with the controls, as a percentage proportion of the fatty acids in the progestin-only and DMPA groups. Calculation of the amounts of linoleic acid per litre of milk revealed that there had been a significant decrease of linoleic, eicosadienoic, dihommo-gamma-linolenic, arachidonic, docosatetraenoic acids in the w6 family and alpha-linolenic acid in the w3 family in the first two post-treatment visits (3 and 4). This reduction in essential fatty acid output follows the reduction in milk volume. In Khon-Kaen, the combined pill group showed a significant decrease compared with the controls, in the proportions of dihommo-gamma-linolenic acid. The difference in response of the mothers in Khon-Kaen and Szeged is discussed in relation to their different nutritional backgrounds.

Contraceptive Agents↗
PubMed1986

Pre-evacuation dilatation of the pregnant uterine cervix by Laminaria japonica.

Laminaria japonica was used as pre-dilator of the pregnant uterine cervix prior to termination of pregnancy in the first and second trimester. In the first trimester (6-11 weeks, n=26) no other method was used, while in the second trimester pharmacological stimulation--prostaglandin F2 alpha or the prostaglandin analogue Sulprostone was used after or simultaneously with the laminaria insertion (12-18 weeks n=34 and 40, respectively). The dilatatory effect of laminaria was an obvious help in termination of both first and second trimester pregnancies.

Abortifacient Agents, Nonsteroidal↗
PubMed1986

Pregnancy, delivery and lactation in hyperprolactinaemic women.

A report is given of 87 pregnancies in hyperprolactinaemic women treated with bromocriptine. The high prolactin level in 11 cases was caused by hypophyseal adenoma. If the plasma prolactin level exceeded 5000 mU/l during pregnancy, bromocriptine was administered until delivery. If the initial prolactin value was over 1000 mU/l, the prolactin level was measured during pregnancy, delivery and the lactational period. After weaning, the prolactin level was again elevated in the majority of cases. During pregnancy, delivery and lactation, complications which differed significantly from the usual were not observed, pregnancy and nursing took place normally. Breast feeding was not contraindicated in any of the cases. Among the newborns, adaptation disturbances and congenital malformations, showed the usual frequency. In the authors' opinion pregnancies which occur during the treatment of hyperprolactinaemic patients need increased care. Complications during pregnancy, delivery and nursing period were not more frequently observed either in the mother or the newborn. The hyperprolactinaemic syndrome did not deteriorate during gestation and lactation, but its normalization can not be expected.

Bromocriptine↗
PubMed1986

[Acute pelveoperitonitis with an IUD in place].

Pelvic inflammatory diseases observed within 5 years in the department of obstetrics and gynaecology of the University of Szeged and caused by intrauterine conception have been studied retrospectively. The cases were 78 times mild and 53 times severe. Mostly the symptoms could be observed following long-time use. Treatment was a combination of chloramphenicol and gentamycine with addition of metronidazole. If there was no remission colpotomy and drainage were performed. If this manoever was not successfull laparotomy (salpingoophorectomy, hysterectomy) was necessary. Intraperitoneal lavage with antibiotics was done by means of a drain. The authors are of the opinion, that insertion of IUD is allowed only in cases of negative gynaecological findings. Continuous supervision is compulsory. In cases of minimal complaints removal of IUD has to be considered.

Adult↗