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Biomedical subjects

M Sas

Publications and source records attributed to M Sas.

At least 19 recordsLinked to original sources
PubMed1991

[Pulsatile gonadotropin-releasing hormone substitution following excision of a craniopharyngioma with suprasellar invasion].

Craniopharyngeoma growing suprasellary attacks the medio-basal region of hypothalamus, that leads to the stopping of the production of gonadotropin releasing hormone. In connection with the case of a 15-year-old girl who had partial extirpation of craniopharyngeoma the authors write about the favourable endocrine effect of pulsatile gonadotropin releasing hormone treatment. Through giving gonadotropin releasing hormone every 90 minutes in 20 micrograms doses menstruation cycle and ovulation was performed. Beside surgical treatment hormonal substitution plays an important role in the treatment of additional endocrine symptoms.

Adolescent↗
PubMed1989

[Treatment of functional infertility, caused by luteal deficiency, with pulsatile perfusion of gonadotropin releasing hormone].

The prehistory of cyclical development of corpus luteum goes back to early follicular phase. Reduced secretion or defective rhythm of gonadotropin releasing hormone (GnRH) can later cause unperfect ovulation or corpus luteum insufficiency. The authors carried out a low-dose pulsatory GnRH-treatment on eight patients with luteal insufficiency, who were earlier treated unsuccessfully with other ovulation-inductive methods (clomiphene, hCG, bromocryptin). As a result of GnRH administration hypertherm period expanded, plasma progesteron level increased and three pregnancies occurred. In their opinion exogenic administration of GnRH results in an improvement of luteal function.

Corpus Luteum Hormones↗
PubMed1989

[Changes in the prolactin level under the effect of pulsatile infusion of gonadotropin releasing hormone].

Plasma prolactin levels were measured in 18 GnRH loading tests and, in 24 cycles involving treatment with GnRH. During 17 GnRH loading tests the prolactin levels production remained virtually unchanged, the individual GnRH pulses not raising the prolactin level. In one case the GnRH loading test led to a considerable rise in prolactin level, which is considered to be a pathological prognostic sign as concerns subsequent GnRH treatment. During unsuccessful pulsatile GnRH treatment, the prolactin secretion in monotonous, while treatment resulting in ovulation, even in hyperprolactinaemia cases, is accompanied by higher prolactin levels in the preovulation and luteal periods than in the early follicular phase.

Adult↗
PubMed1989

Ovulation induction with pulsatile administration of human menopausal gonadotropin.

Ovulation induction was performed by the pulsatile administration of subcutaneous human menopausal gonadotropin (hMG). Treatment was started with a daily dose of 75 IU hMG (in a 90% distribution), then it was increased to 150 IU depending on the oestradiol level of the plasma and on the result of folliculometry. Of 10 cycles treated ovulation was induced in 7 cases and two pregnancies occurred. In two cases, following a previous unsuccessful intramuscular hMG treatment, ovulation was induced. Hyperstimulation did not occur. The pulsatile s.c. administration of hMG seems to be an adequate ovulation-induction method in ovulatory disorders of hypothalamo-hypophyseal origin and is a good substitute for the missing, endogenous gonadotropin secretion of inadequate pace.

Adult↗
PubMed1989

Possible means and efficiency of the treatment of infertility.

Diagnostic methods which allowed to understand exactly the mechanism of infertility have been developed within the past four decades. For drug therapy effective gamete production stimulating products have been developed and important progress has been made in operative technique. Due to this progress this condition may be successfully treated in many cases. The effectiveness of treatment depends on the efforts of the given institution to solve this problem and on the willingness of the staff to adapt new diagnostic and therapeutic methods.

Female↗
PubMed1989

Variations in prolactin secretion in hyper- and normoprolactinaemia with or without galactorrhoea.

The circadian variations and secretory rhythms in prolactin secretion were examined in 10 hyperprolactinaemic and 10 normoprolactinaemic women with or without galactorrhoea in order to establish a clearer picture of this secretion and to find, if exists, correlation between the prolactin level and galactorrhoea. In the normoprolactinaemic women a rhythmical rise and fall were observed within 20 min, with higher values during nocturnal sleeping; these changes were more marked in the galactorrhoeic group. In the hyperprolactinaemic group the diurnal and pulsation changes were less pronounced, galatorrhoea usually being accompanied by a higher degree of hyperprolactinaemia. In galactorrhoeic patients with a normal basal prolactin level, a relative prolactin excess may be reckoned with at certain times. A proportion of these women can in fact then be regarded as hyperprolactinaemic. In the hyperprolactinaemic cases without galactorrhoea, a decreased prolactin sensitivity and milk-forming ability of the breasts may be assumed.

Adult↗
PubMed1987

The modulating effect of estrogens on luteinizing hormone release in complete androgen insensitivity syndrome before and after gonadectomy and cyclic steroid application.

The response of LH release to exogenous estrogens was studied in three patients with androgen insensitivity syndrome (AIS) before and after gonadectomy and a prolonged treatment with a sequential pill. Estrogen provocation tests were performed in which 0.05 mg/kg body weight estradiol benzoate was administered intramuscularly and serum FSH and LH levels were assessed every 12 hours for 96 hours after gonadectomy, three months after a prolonged treatment with a sequential pill (16 cycles: 9 days mestranol 100 micrograms, 12 days mestranol 80 micrograms and chlormadinone acetate 2 mg) and in one patient before gonadectomy. The control group consisted of 10 normal females during the follicular phase. A positive feedback effect was induced in normal females and in AIS patients after prolonged treatment with a sequential pill.

Adolescent↗
PubMed1979

Impaired spermiogenesis as a common finding among professional drivers.

The effect of long-term driving upon spermiogenesis was investigated in 2984 patients, including 281 professional drivers. The incidence of pathospermia was significantly increased among the 281 occupational drivers as compared to other professionals. The ratio of severe pathospermia was increased in proportion to the number of years of driving. The deterioration of spermiogenesis was mild among car drivers, but was severe in agricultural-industrial hard machinery and farm equipment drivers. There was a higher incidence of impaired fertility in drivers as compared to other professionals. The possible factors influencing these results are discussed.

Adult↗
PubMed1979

Bradykininase and protease inhibitors in seminal plasma of fertile and infertile men.

The level of protease acrosin in the seminal plasma of oligozoospermic men was significantly higher than that of normozoospermic men. The amount of bradykininase in the seminal plasma was very high in both normozoospermic and oligozoospermic patients. When the acrosin and kininase content was referred to one million spermatozoa, seminal plasma kininase was significantly enhanced in oligozoospermic men, while the acrosin activity was similar in normozoospermic fertile men and infertile men. Human seminal plasma inhibitor I (HUSI I) increased along with sperm count. Human seminal plasma inhibitor II (HUSI II) showed no change. The motility of spermatozoa was depressed in oligozoospermic patients.

Acrosin↗
PubMed1979

[Hormonal situation on parturition, early puerperium, and lactation (author's transl)].

Variations of the 17-beta oestradiol, progesterone, and prolactin levels in the serum were studied in the context of ten spontaneous parturitions. All cases were investigated within the first five puerperal days, but in five cases additional checks were undertaken over the first four weeks of the puerperium. Milk secretion was measured, as well. The oestradiol and progesterone titres were found to remain below the level common toward the end of pregnancy. They dropped rapidly after parturition and remained low throughout the puerperium. Prolactin underwent slight variation on parturition, but it actually stayed at the high level measurable at full term. Parturition was followed by brief temporary rise and, again, by decline, but values remained above those of non-pregnant women throughout puerperium. Milk production increased gradually over the first five days and remained similarly high throughout several weeks, accompanied by accordingly high prolactin levels. No absolute correlation was found to exist between the extent of lactation and the prolactin level. The presence of a relationship between oestradiol and progesterone levels, on the one hand, and lactation, on the other, cannot be assumed with probability.

Estradiol↗
PubMed1979

[Clinical importance of antiprolactinaemic treatment of functional infertility (author's transl)].

Reported in this paper is the effectiveness of antiprolactinaemic treatment of 40 infertile women. All case histories revealed previous unsuccessful attempts to induce ovulation. Antiprolactinaemic treatment was in all cases preced by RIA determination of prolactin and gonadotrophin. Prolactin levels were found to be somewhat increase in 19 cases, while 21 women were normal. The gonadotrophin plasma levels usually were closer to the lower limits of normal values. The presence of hypophyseal adenoma had been ruled out beforehand. Long-time treatment was based on the administration of 5 mg Parlodel/die. The effect was excellent in all cases of hyperprolactinaemia, but response was recorded, as well, from a group of patients with normal prolactin levels. Galactorrhoea ceased to exist in all cases. Clomiphen was applied again to induce ovulation in those patients who had not responded at all or developed only bleeding without ovulation. That treatment proved to be effective in several cases.

Adult↗
PubMed1978

[Sex education and education for family life in adolescents].

A program of education of college girls and boys between 14--18 years of age for sexual and family life is going on in the Hungarian secondary school. There are 20 lectures within 4 years. The goal and the subjects of the lectures specially designed for each semester are outlined by the author.

Adolescent↗
PubMed1978

[Contraception in children and adolescents].

It is discussed how the adult type contraception fits the divergent needs of the youngsters. Oral contraceptives are suitable from the 16th year of life. Vaginal globuli and foams have also proved to be an effective means of contraception over that period of life. For anatomical reasons pessaries are not recommended, insertion of intrauterine devices is contraindicated because of their possible adverse effects. Experiences with university students taking d-Norgestrel as "morning-after-pill" have been favorable. The therapeutic abortion is regarded as an emergency measure to be employed only if anticonception failed. Adaequate education at the proper age and the importance of preventive measures are stressed.

Abortion, Spontaneous↗
PubMed1978

Mesterolone treatment of patients with pathospermia.

The response to Mesterolone, in doses of 25 mg/day, was examined in 42 pathospermic patients. Treatment lasted for 100 days. The pronounced response to the Mesterolone treatment was observed in hypozoo- and oligozoospermia with low initial fructose content in the ejaculate. Fructose content attained its normal range after the treatment. During the therapeutic period 11 wives became pregnant. The authors conclude that Mesterolone does not influence plasma FSH, LH and testosterone levels, it has only peripheral effects.

Adult↗