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Biomedical subjects

M Sano

Publications and source records attributed to M Sano.

At least 721 records · Page 40Linked to original sources
PubMed1979

Identification of carpronium chloride and its metabolite in human urine by field desorption mass spectrometry using deuterium labelling.

The identification of carpronium chloride and a metabolite in human urine has been performed by means of field desorption mass spectrometry using deuterium labelling. Essential points in this study are the simultaneous administration of a deuterium labelled drug ([2H9]carpronium chloride), a purification procedure by ion pair extraction with an iodine reagent, and the use of paper electrophoresis to examine the degree of clean-up. The field desorption mass spectra of the purified extracts obtained from sample urine gave a characteristic pattern resulting from the carpronium cation (m/z 160, m/z 169) and a metabolite of the N-(3-carbohydroxypropyl)trimethyl ammonium cation (m/z 146, m/z 155).

Adult↗
PubMed1979

Effects of celiacectomy and stellatectomy on gastric mucosal innervation and acid secretion in the dog.

The effect of surgical excision of the celiac and superior mesenteric ganglia and the stellate ganglia, respectively, on gastric acid secretion and adrenergic innervation of gastric mucosa was studied in five dogs. After removal of the abdominal ganglia, there was a significant increase in acid secretion while there was a marked decrease in the number of adrenergic nerve terminals in the mucosa. When, addition, the stellate ganglia were excised, acid secretion increased slightly in two dogs, while little change in mucosal innervation was noted. These data suggest that the adrenergic innervation of the stomach has an inhibitory role in the control of acid secretion in the dog. Vagal adrenergic nerve fibers seem to be of limited importance in gastric acid production.

Adrenergic Fibers↗
PubMed1979

Observations of vincristine-induced paracrystals in human erythroblasts in vitro.

Ultrastructural observations were made on human erythroblasts incubated in a vincristine solution. In certain concentrations and at certain incubation time intervals, paracrystals were observed in the erythroblasts. The fine structure of the paracrystals was similar to that described in platelets, leukemic lymphoblasts or cultured fibroblasts. They showed parallel filaments, amorphous mass or honeycomb-like crystalline structure. One paracrystalline form turned into another form when the sections were tilted by the use of goniometer. These paracrystals were often closely related to other organelles, such as lysosome, Golgi apparatus and nucleus. In the mitotic erythroblasts degraded microtubules coexisted with typical paracrystals.

Cells, Cultured↗
PubMed1979

Metabolism of budralazine, a new antihypertensive agent, III.

1. [14C]Budralazine (I) administered orally to normotensive and spontaneously hypertensive rats showed no significant difference in metabolic fate between the two groups. 2. Peak plasma levels of 14C were 3.6 microgram equiv. of I per ml in both normotensive and hypertensive rats. Approx. 5% of total 14C in the plasma consisted of I within 4 h, but thereafter the parent drug was not detected. Approx. 15% of 14C in the plasma consisted of 1-hydrazinophthalazine within 16 h after the administration. 3. 45% and 37% of the dose of 14C was excreted into urine and faeces within 24 h, respectively. 4. A high retention of 14C in the aorta wall was found and the time course of 14C in the aorta wall was compatible with that of the reduction in blood pressure. The radioactive materials retained in the aorta wall were likely to be I or 1-hydrazinophthalazine, probably the latter, following macroautoradiography in hypertensive rats.

Animals↗
PubMed1979

Accelerated serum sickness in the rabbit. IV. Characteristic endarteritis in the pulmonary artery.

A unique angiitis developing in acute serum sickness in the rabbit was studied by immunofluorescence and light microscopy and by transmission and scanning electron microscopy. The angiitis occurred predominantly in the pulmonary artery and was characterized by a prominent accumulation of monocytes in the subendothelial space. During the early stage, scanning electron microscopy revealed the occurrence of various endothelial alterations, especially the formation of many endothelial holes leading to a subendothelial emigration of monocytes. There was neither emigration of polymorphs nor significant thrombotic lesion, and it is possible that this was due to a paucity in the amount of immune complexes deposited. The monocytes ingested platelets and fibrin, suggesting their preventive role in the development of thrombotic changes. The intimal change resolved within several days, leaving only slight fibrosis. A distinct resemblance in the disease process between this type of angiitis and acute serum sickness nephritis is emphasized.

Animals↗
PubMed1979

Vestibular neuronal function during ischemia. Response of vestibular neurons to vertebral and carotid artery occlusion in rabbits.

The relation between ischemia experimentally produced by occlusion of arteries injecting to the brain and the changes in vestibular excitability was examined in 102 rabbit vestibular neurons responding to sinusoidal rotation. During occlusion of ipsilateral and/or contralateral vertebral and common carotid arteries, the neuronal activity took on three different patterns with respect to the frequency of neuronal discharge. The incidence of alteration of neuronal activities reflected vestibular excitability dependent on hemodynamic changes due to occlusion of the ipsilateral vertebral artery rather than due to occlusion of the contralateral artery. Occlusion of common carotid arteries caused no significant difference between the right and left vessels in the resultant change of the neuronal activity, and differed little, either, from occlusion of vertebral arteries in the incidence of the changes. A supplementary experiment, in which the four arteries were only partially occluded, clearly showed that the resultant changes in neuronal activity reflect the role of Willis' circle in the maintenance of blood flow to vestibular nuclei.

Animals↗
PubMed1979

Flameless atomic absorption spectrophotometric determination of Vendex, an organic tin miticide, in apples, oranges, and tea leaves.

A method is described for the determination of an organic tin insecticide, Vendex or hexakis(2-methyl-2-phenylpropyl)distannoxane (HMPD). Tin compounds are extracted from the sample homogenate with ethyl ether containing 1% acetic acid. HMPD and its degradation products are separated through a silica gel column, and analyzed by an atomic absorption spectrophotometer coupled with a heated graphite atomizer. By this technique, as little as 5 ng HMPD and its degradation products can be determined with an average recovery of 67-96%.

Citrus↗