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Biomedical subjects

M Sandbank

Publications and source records attributed to M Sandbank.

At least 145 records · Page 8Linked to original sources
PubMed1982

Studies of Kaposi's sarcoma with infrared photography.

Infrared photography, known to be useful in the study of cutaneous vascular structures but not yet extensively explored in the investigation of skin diseases, was used to study lesions of Kaposi's sarcoma in three patients. In all photographs, the tumors appeared as a stain which was lighter in color than the normal skin. In two patients, the infrared photographs showed a tumor identical with that seen clinically. In the third patient, the tumor showed a larger extension than it seemed to have on physical examination. We believe that this technique can be of value in establishing the presence of such tumors and evaluating their actual size.

Humans↗
PubMed1980

An unusual case report: tinea capitis, verrucae vulgares and other infections in a girl with T and B cell disturbances.

Hereby described is a case of a young girl suffering from widespread dermatophytosis caused by Trichophyton violaceum which proved intractable to accepted methods of therapy throughout a number of years. The girl was also found to have a history or recurrent respiratory tract infection and pyoderma in addition to verrucae vulgares, and Giardia lamblia in the gastrointestinal tract. Investigation revealed a marked immunological deficit seen in both the cellular and humoral system. It is suggested that in similar cases resistant to therapy it may be helpful to carry out a comprehensive investigation of the immunological system.

Antibody Formation↗
PubMed1979

Disseminated superficial porokeratosis in patients with pemphigus vulgaris treated with steroids.

In two patients with pemphigus vulgaris a rash identical with that seen in disseminated superficial porokeratosis developed on the trunk and extremities during periods in which they were receiving relatively high doses of steroids. Some time after reduction of the daily dose or discontinuance of treatment this rash disappeared. In one patient, however, this rash subsequently recurred twice, both times after reinstitution of treatment because of the reappearance of pemphigus lesions. It is suggested that disseminated superficial porokeratosis should be added to the list of possible skin eruptions developing as the result of the systemic use of corticosteroids at a high dose for a prolonged period of time, although the mechanism of its appearance in these cases is not yet clear.

Female↗
PubMed1979

Two siblings with epidermodysplasia verruciformis with large clear cells in the epidermis: electron microscope and immunological findings.

In two Arab brothers presenting the characteristic clinical picture of epidermodysplasia verruciformis (EV), histological examination revealed large clear cells in the granular layer and uppermost part of the prickle cell layer of the epidermis. The report of this histological picture in two cases by other authors in the past had aroused considerable discussion as to the true diagnosis. The finding of large clear cells in our two confirmed cases of EV supports the opinion that this does not necessarily contradict the diagnosis of EV. Electron microscope investigation revealed groups of particles in the nuclei of a few keratinocytes in the granular layer which were compatible with papova virus particles. The changes seen in the clear cells support the theory of the viral etiology of EV. Ehe immunological studies showed intact humoral immunity but impaired cellular immunity.

Adolescent↗
PubMed1978

Pseudolymphoma of skin induced by oriental hornet (Vespa orientalis) venom ultrastructural study.

A single subcutaneous injection of Oriental hornet venom into black mice led to the development of a subcutaneous nodule which showed no change during the period of 1 year. Study of the ultrastructure revealed an accumulation of lymphocytes and lymphoblasts and a few plasma cells with formation of Russel bodies. In addition, a few melanin-containing macrophages and macrophages filled with cellular debris were found. This reaction is compared to other pseudolymphomatous reactions in the dermis.

Animals↗
PubMed1978

Multiple fibroepithelial hyperplasias of the oral mucosa.

Reported is a rare case of multiple fibroepithelial hyperplasias of the oral cavity, and the suggestion is made that several previous authors may have confused this lesion with focal epithelial hyperplasia (Heck's disease). The differential diagnosis of multiple fibroepithelial hyperplasias is discussed in order to elucidate some of the confusions in the diagnosis of cases of multiple papules and nodules of the oral mucosa.

Connective Tissue↗
PubMed1977

Cross-striated banded structures in cutaneous leishmaniasis.

Banded structures were observed in 4 cases of cutaneous leishmaniasis. These structures were found in proximity to macrophages containing leishmania and were intermingled with native collagen, elastic fibres and ground substance fibrils. The possibility that banded structures are an indication of active, accelerated collagen production is discussed.

Adolescent↗
PubMed1976

Cutaneous leishmaniasis. Ultrastructural study of 3 cases.

Ultrastructure study of specimens taken from 3 patients with cutaneous Leishmaniasis showed parasites within macrophages. None were found in extracellular locations. Within the macrophages cytoplasm, parasites were located either lying free in the cytoplasm or inside intracytoplasmic vacuoles. Parasites in various stages of degeneration were found both lying free in the cytoplasm or within vacuoles. The parasite-macrophage relationship and the mechanism by which the host reacts toward the parasite are discussed.

Adolescent↗
PubMed1976

Pseudolymphoma of skin induced by oriental hornet (Vespa orientalis) venom.

Intradermal injection of saline suspension of Vespa orientalis venom sac to 57 black mice caused a local nodule composed of lymphocytes, few histiocytes and plasma cells 10 to 12 days following the injection. This reaction simulates the pseudolymphoma reaction observed in humans following arthropode stings.

Animals↗
PubMed1976

Cutaneous nerve lesions in prurigo nodularis. Electron microscopic study of two patients.

Skin biopsies from two patients with pruirgo nodularis were studied with the electron microscope. Lesions were found in the cutaneous myelinated and unmyelinated nerves. Schwann-cell cytoplasm showed large, irregular, membrane-bound, electron-lucent vacuoles. Umyelinated axons were distended and devoid of neurotubules and neurofilaments. Myelinated nerves showed various degrees of demyelination. Onion-bulb formations with a centrally located myelinated fibre were also observed and numerous mast cells were found in the cellular infiltrate. All these findings indicate the presence of a chronic peripheral neuropathy, the etiology of which remains to be determined.

Adult↗
PubMed1976

Histiocytosis X with skin lesions as the sole clinical expression.

The case is presented of a patient with histiocytosis X of the skin of some 25 years' duration. Extensive investigation failed to reveal any other signs of the disease in other organs. The light and electron microscope findings are described. The electron microscope study revealed an abundant cytoplasm with numerous mitochondria, vacuoles, dense bodies, a well-developed Golgi apparatus and numerous Langerhans' cell granules.

Cytoplasm↗
PubMed1975

Prurigo nodularis. Histological and electron microscopical study.

We describe a typical case of prurigo nodularis, of 15 years' duration, in a middle-aged woman. Histological and electron microscopical examination of the skin lesions revealed distinct changes in the nerve tissue. There were groups of thickened nerve fibers that formed nodules with numerous Schwann cells. Some of the nerve bundles extended to the dermoepidermal junction. Electron microscopy showed very obvious lesions in the Schwann cells and axons. In the Schwann cells there was a lucent cytoplasm with few mitochondria, an absence of endoplasmic reticulum and a few irregular, membrane-bound vacuoles. While the mesaxons all appeared normal, the axons varied greatly in diameter; the small ones appeared normal and contained neurofibrils and neurotubules, whereas the large onew were empty. Every Schwann cell encircled a large number of axons. It may be assumed that the axon swelling is a nonspecific reaction to injury.

Adult↗