Search PubMed⌕ Search

Biomedical subjects

M Salzer

Publications and source records attributed to M Salzer.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Treatment and prognosis of osteosarcoma in childhood (author's transl)].

126 osteosarcoma under the age of 15 years are followed up in an interclinical study. There is a steady increase of tumor incidence towards the 15th year with a slight male preponderance. The main sites of the tumor are the distal femur followed by the proximal tibia and humerus. Evidence of multiple metastases is most often present in the lungs, less often in the skeleton. Nearly always metastases became evident within 2 1/2 years after diagnosis (98%). Therefore the 2 1/2-year disease--free survival rate seems to be sufficient for prognostic evaluation. The over all 2 1/2-year survival rate was 17,5%. Though the different methods of treatment are not statistically valid, the best results can be expected after early amputation. By radiotherapy alone no cure has been achieved. Survivals were seen at any age and at any site of long bones (distal femur, proximal tibia, humerus, femur, distal radius). Prognosis of osteosarcoma in the childhood is similar to that of the adult group.

Adolescent↗
PubMed1976

Further experimental and clinical experience with aluminum oxide endoprostheses.

This paper describes the design principles of a new endoprosthesis made of dense aluminum oxide (A12O3) and implanted without bone cement. Mechanical tests and animal experiments have proved the sufficient mechanical strength of the bone-prosthesis connection as well as the biocompatibility of the material. So far, 12 tumor patients selected according to strict indication criteria have been operated on. Both the clinical-radiologic and the first histological findings available are encouraging. Special reference is made to the first fully ceramic total hip joint endoprostheses implanted in a human without bone cement.

Aluminum↗
PubMed1976

The immune-status in patients with bone and soft-tissue sarcomas.

The immunologic status of 50 sarcoma patients was established. It was possible to apply the DNCB test and the recall antigen test in most cases during the course of the illness. The PHA stimulation of the lymphocytes and their cytotoxicity on homologous sarcoma cell lines were also correlated with the course of the illness. Nonspecific tests related neither to each other nor to the development of the illness while the tumor-specific cytotoxicity test correlated closely with the course of the disease.

Adolescent↗
PubMed1976

Resection of malignant bone tumors.

Amputation is an unsatisfactory and depressing measure for the patient as well as for the surgeon. As long as operative removal of tumors in the extermities is indicated, the search for alternative solutions should be the most urgent task for every doctor involved in surgery. Resection would be the most equitable measure as far as demands for radicality and the best possible restoration of function are concerned. In order to warrant the radicality of the operation, meticulous preoperative planning and precise surgical techniques are essential. Sufficient restoration of function must take into consideration all the factors of the individual case, age and profession of the patient playing a large role. After partial resection of longer tubular bones, fitting of an endo-prosthesis has proved to be advantageous. Implants available at present have various drawbacks; studies directed at the elimination of these drawbacks must be set up.

Adolescent↗
PubMed1975

[Atypical amputations of bone tumors of the lower extremity (author's transl)].

The most predominant problem concerning malignant tumors in the lower extremities is the radical removal of the tumor, for this almost always involves amputation. Referring to the eventual outfitting of a prosthesis one must keep functionality in mind from the start. This includes all the planing for the preservation of a stump that can be fitted with a prosthesis. Experience has confirmed the advantages of foot-root stumps and knee disarticulation. Good functional results can be attained with tumors of the femur in individual cases through atypical operations. This involved elongation of the stump by means of a fibula transplant; replacing the femur with a bioceramic endoprosthesis; and rotation-plasty, whereby the knee joint is replaced by the ankle joint.

Adolescent↗
PubMed1975

Experiences with Al2O3 implantations in humans to bridge resection defects.

Various implants have been developed for the upper and lower extremities and the spine. In order to establish whether endoprostheses made of Al2O3 will show the same good biocompatibility in humans as it has in experiments with animals, endoprostheses implantations were performed in 4 patients: 2 upper arms, 1 radius, 1 vertebra body. The implants were exposed to various loads. The biomechanical conditions were considered in the construction. The results reveal that the knowledge of material properties and prior calculations make possible the development of satisfactory endoprostheses. X-ray examinations confirm these deductions. Good functionality was achieved in vivo with all implants. They were all mechanially anchored, no bone cement was used. Thus the biocompatibility of the material was not limited. A histological examination is made of one implant. The macroscopic examination showed a stable fit and no pathological reactions, X-rays revealed that the bone remained in good contact with the implant. The longest observation period was over 1 1/4 years. Present observations show that the use of Al2O3 implants, without the use of additional materials (bone cement), results in a tight fit of the implants.

Aluminum↗
PubMed1975

Osteosarcoma in children. A study of 125 cases.

A study is presented of the aetiology and results of treatment in a group of 125 proven osteosarcomas present in children under fifteen years of age. These cases have been collected from the records of one English and six European treatment centres. There is a slight male preponderance, but the striking aetiological feature is the very high proportion of tumours of the long bones of the limbs (96 per cent). The two and a half and five year disease-free survival rates were respectively 15 and 12 per cent, with a further 9 per cent still living, but under observation for less than two and a half years. Evidence of metastasis after two and a half years is very unusual, but no child with a tumour of an axial or girdle bone lived this length of time. Although the differences in the results of the different methods of treatment employed are not statistically valid, the largest number of long survivors had been treated by early amputation, which method also provided the lowest rate of local tumour recurrences. Reasons are discussed which indicate that prompt ablation is the treatment of choice, perhaps with certain advantages in the light of recent advances in adjuvant treatment. The past situation in connection with childhood osteosarcoma certainly provides strong support for immediate carefully designed clinical trials of the new adjuvant methods cited.

Age Factors↗
PubMed1975

Resection therapy of malignant tumours of the shoulder girdle.

Based on 30 resections in the shoulder region, operation techniques and results are precisely described with a view to curing and functioning. In the case of radical resections the rate of recurrences and cures in patients are the same as the rate of ablations. As the function of the hand is not impaired, this is a considerable advantage over amputations, although the cosmetic result of a resection may appear insufficient. In humerus resections bending contractures may frequently occur in the elbow joint and previous radiation may occasionally cause interior decubitus and exculceration. With an endoprosthetic replacement of the proximal humerous complications may be avoided, as experience with ceramic implants proved in 3 cases.

Adolescent↗