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Biomedical subjects

M Saigusa

Publications and source records attributed to M Saigusa.

At least 55 records · Page 3Linked to original sources
PubMed1977

Pulmonary regurgitation following total correction of tetralogy of Fallot.

A method is described for quantifying pulmonary regurgitation. This method is based on a comparison of the right and left ventricular stroke volumes which are determined from biplane angiocardiograms. These techniques were applied to study 18 postoperative patients with tetralogy of Fallot. In patients with an outflow patch, regurgitant fraction was well correlated with regurgitant area. The RVEDV/LVEDV ratio was also correlated well with regurgitant fraction. Although majority of patients maintained normal RV ejection fraction, there were small number of patients with large regurgitant fraction and decreased RV ejection fraction.

Adolescent↗
PubMed1977

Optimal size of outflow patch in total correction of tetralogy of Fallot.

Hemodynamic and angiocardiographic studies were performed in postoperative patients with tetralogy of Fallot. Pressure gradient between the right ventricle and pulmonary artery was correlated with the narrowest area in the pulmonary arterial pathway. Regurgitant fraction was also correlated with regurgitant area which was determined by preoperative area of the pulmonic annulus and width of the outflow patch. Follow-up study of postoperative patients with tetralogy indicated that those with pressure gradient less than 20 mmHg and regurgitant fraction less than 15% could be considered ideally corrected. A table was constructed for determining the most appropriate width of the outflow patch for the ideal correction.

Humans↗
PubMed1976

Echocardiography and angiocardiography for detection of left atrial thrombosis.

Diagnostic capabilities for detection of the left atrial clot in patients with mitral stenosis were compared between echocardiography and angiocardiography. Large clots in the left atrial body were correctly diagnosed either by echocardiography or by angiocardiography. Clots in the left atrial appendage were not disclosed by echocardiography. Left atrial visualization with pulmonary arteriography offers only possible diagnosis of the clot in the appendage. Definite diagnosis of the clot in this location requires transseptal left atriography.

Angiocardiography↗
PubMed1976

Effects of allopurinol on tissue oxygen tension of the ischemic myocardium.

The effects of allopurinol on the myocardial oxygen metabolism were studied in dogs with acute coronary artery occlusion. Upon occlusion of the contributory branch of the coronary artery, myocardial pO2, as measured with an improved polarographic technique, decreased to various lower values depending on the site of the electrode inserted. In the slightly ischemic myocardium, where myocardial pO2 decreased less than 50% of the control by the coronary occlusion, administration of allopurinol brought about a further diminution in myocardial pO2. In the severly ischemic myocardium, where myocardial pO2 decreased more than 50% of the control upon the coronary occlusion, no significant change was observed following allopurinol infusion. Theoretical beneficial effects of allopurinol on the ischemic myocardium by preserving functional purine bases might be offset by the aggravation of the negative oxygen balance in the ischemic but still viable myocardium following administration of allopurinol.

Allopurinol↗
PubMed1974

Relationship of plasma aldosterone concentration to electrolytes and acid-base balance in blood after open cardiac surgery.

Plasma aldosterone concentration was measured in 11 cardiac patients after open cardiac surgery, by the radioimmunoassay method, and the relationship of it to electrolytes and acid-base balance of blood was analyzed. Plasma aldosterone concentration was markedly elevated in patients with low cardiac output, who required postoperative drip infusion of Isoproterenol, and in addition, both remarkable metabolic alkalosis and increase of potassium excretion in urine were confirmed in these patients. Plasma aldosterone concentration correlated significantly with potassium excretion in urine and was inversely related with potassium balance. However, plasma potassium concentration or arterial pH had no correlation to it. Approximately an inverse correlation was found between the logarithm of the sodium/potassium ratio in urine and plasma aldosterone concentration. These data indicate that aldosterone is an important factor which produces potassium depletion after open cardiac surgery.

Acid-Base Equilibrium↗