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Biomedical subjects

M Saeki

Publications and source records attributed to M Saeki.

At least 127 records · Page 7Linked to original sources
PubMed1988

Long-term results of jejunal replacement of the esophagus.

Since 1969, jejunal interpositions have been carried out in 19 patients for esophageal replacement. A segment of the upper jejunum was used to bridge the gap in the right thoracic cavity. The distal esophagus and its sphincteric mechanism was preserved in all but four patients, who had peptic strictures. Early postoperative complications such as total necrosis of the graft, perforation of the graft, and anastomotic leak developed in three patients (16%). There were no operative deaths but there were two later deaths (11%). We were able to follow 12 patients over a long term. Among these 12 patients there were two anastomotic strictures, one of which was dilated successfully by bouginage, and one marked redundancy of the jejunum which necessitated surgical correction. Both height and weight were lower than -2 SD on a Japanese standard growth curve in two patients who had anastomotic strictures. Transient stagnation of swallowed barium at the lower esophagus was the common finding; it was observed in seven cases (58%). Only three patients (25%) complained of occasional feelings of delay in swallowing. Stagnation with a mildly redundant jejunum was the common radiologic finding in these three patients. Reflux of the gastric content into the esophagus did not occur. All the patients, except one who still has dysphagia due to anastomotic stricture, can eat anything they wish at almost normal speed. These long-term results indicate that jejunal interposition with preservation of the lower esophagus is a recommendable procedure for esophageal replacement.

Adolescent↗
PubMed1988

Syncope in aortic stenosis during continuous electrocardiographic monitoring--a case report.

A female patient with severe aortic stenosis had suffered from repeated syncope. Transaortic valve pressure gradient at cardiac catheterization was 117 mmHg. Continuous electrocardiographic monitoring was done after admission. During syncope, the electrocardiogram showed bradycardia with the lowest heart rate 44 beats per minute, while arterial pulses were not palpable. Rather than arrhythmia, other mechanisms, such as an inhibitory reflex from left ventricular receptors, should be postulated as the cause of syncope in patients with severe aortic stenosis.

Aged↗
PubMed1987

Serial determination of serum neuron-specific enolase in patients with neuroblastoma and other pediatric tumors.

The importance of determination of serum neuron-specific enolase (NSE) in patients with neuroblastoma has been emphasized by several authors. However, the specificity and sensitivity of NSE have not yet been well studied in tumors of infancy and childhood, nor is the role of serial determination of NSE in monitoring these patients fully understood. Concentrations of serum NSE were determined by a newly developed radioimmunoassay technique in 241 samples from 111 patients. NSE was also assayed in sera of nude mice bearing human pediatric tumors (16 samples), as well as in 30 tumor specimens. Eighty-two serum samples from 19 patients with neuroblastoma all showed NSE values (mean 120.2 ng/mL, range 16.2 to 722.0 ng/mL) elevated beyond the upper border of the normal range (14.6 ng/mL), even though four of the 19 patients had normal urinary excretion of 3-methoxy-4-hydroxymandelic acid (VMA) and 3-methoxy-4-hydroxy-phenylacetic acid (HVA). Twelve of these patients were monitored with serial NSE determinations, and their serum NSE were found to correlate well with the tumor burden, but were transiently modified by chemotherapeutically induced cell death. All 68 samples from nine patients, free of neuroblastoma at assessment, showed NSE values within the normal range. Thirteen of 25 patients with tumors other than neuroblastoma, however, showed serum NSE values mildly elevated beyond the upper border of the normal range (mean of the 25 patients 36.7 ng/mL, range 5.0 to 234.0 ng/mL). Results from our nude mouse study and from NSE analysis of the tumor extracts paralleled the clinical results.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1987

[Bone metastasis of malignant solid tumors in childhood].

A total of 452 cases of childhood malignant solid tumors were treated over the last twenty years at the National Children's Hospital. These included 175 cases of neuroblastoma, 64 cases of Wilms' tumor, 65 cases of malignant lymphoma, 45 cases of soft tissue sarcoma, 31 cases of hepatoma, 20 cases of malignant teratoma, 17 cases of testicular tumor, 7 cases of ovarian tumor and 28 cases of other forms of malignant solid tumor. Bone metastasis was observed in 62 of 175 cases of neuroblastoma, 3 of 64 cases of Wilms' tumor, one of 65 cases of malignant lymphoma, 4 of 45 cases of soft tissue sarcoma, one case of pulmonary blastoma and one case of osteogenic sarcoma, giving a total occurrence of bone metastasis in 72 of the 452 cases. The main sites of bone metastasis in neuroblastoma were the skull (61.4%), femur (56.8%), orbit (27.3%) and spine (22.7%). The average values of serum calcium and alkaline phosphatase activity showed no significant difference. The patients with bone metastasis were treated with a combination of radiation therapy and intensive chemotherapy, resulting in temporary improvement. The survival of patients with stage IV neuroblastoma with bone metastasis was worse than that of similar patients without bone metastasis.

Bone Neoplasms↗
PubMed1986

Glucose tolerance, blood lipid, insulin and glucagon concentration after single or continuous administration of aspartame in diabetics.

A nutritive sweetener, aspartame (L-aspartyl-L-phenylalanine methylester) was administered orally to normal controls and diabetic patients in order to evaluate effects on blood glucose, lipids and pancreatic hormone secretion. An oral glucose tolerance test was also performed in the same subjects as a control study of aspartame administration. In 7 normal controls and 22 untreated diabetics, a single dose of 500 mg aspartame, equivalent to 100 g glucose in sweetness, induced no increase in blood glucose concentration. Rather, a small but significant decrease in blood glucose was noticed 2 or 3 h after administration. The decrease in blood glucose was found to be smallest in the control and became greater as the diabetes increased in severity. No significant change in blood insulin or glucagon concentration during a 3-h period was observed in either the controls or the diabetics. The second study was designed to determine the effects of 2 weeks' continuous administration of 125 mg aspartame, equal in sweetness to the mean daily consumption of sugar (20-30 g) in Japan, to 9 hospitalized diabetics with steady-state glycemic control. The glucose tolerance showed no significant change after 2 weeks' administration. Fasting, 1 h and 2 h postprandial blood glucose, blood cholesterol, triglyceride and HDL-cholesterol were also unaffected. From these and other published results, aspartame would seem to be a useful alternative nutrient sweetener for patients with diabetes mellitus.

Administration, Oral↗
PubMed1985

The syndrome of posterior thalamic hemorrhage.

In six patients with CT evidence of posterior thalamic hemorrhage, we found the following signs: saccadic hypometria away from the lesion; defective pursuit toward the lesion with corresponding opticokinetic abnormalities; mild ipsilateral ptosis; ipsilateral miosis; unilateral sensory neglect; and sensorimotor hemiparesis. This distinct syndrome has a benign course and satisfactory recovery. It differs from the classic picture of thalamic hemorrhage, and can be called "the syndrome of posterior thalamic hemorrhage."

Aged↗
PubMed1985

Detection of paraesophageal varices by plain films.

Plain-film findings of paraesophageal varices were investigated in 352 patients with portal hypertension. Paraesophageal varices were suggested on routine chest films in 17 cases (4.8%) and on Bucky films in 30 cases (8.3%). Plain-film findings included posterior mediastinal mass shadows, obliteration of the descending aorta, and mass density adjacent to the descending aorta appearing to be intraparenchymal (lesions in the inferior pulmonary ligament). The importance of close observation of subtle findings on plain chest films is stressed.

Esophageal and Gastric Varices↗
PubMed1984

[Desorption behavior of carrier free tritium from the inner surface of a glass ampoule].

The desorption behavior of tritium from the glass ampoule which originally contained 37 GBq of carrier free tritium gas was studied by etching the surface with a diluted hydrofluoric acid solution or by heating at the constant rate up to 800 degrees C. The total amount of tritium sorbed on the inner surface of the ampoule was found to be 3.9 +/- 0.7 GBq. This value corresponded to more than 10% of tritium contained in the ampoule. The release rate of tritiated water (HTO) was 2.3 kBq/cm2.min, and the amount of HTO desorbed was strongly depended on the atmosphere. Thus, special precaution should be paid to the processing of a vessel once containing such an amount of tritium.

Adsorption↗
PubMed1984

[Activities of the Japanese Group for the Study of Anorectal Anomalies].

Although an excellent classification of anorectal anomalies was proposed by Stephens and Smith in 1970, some problems came out when this classification was adopted to the clinical materials. In 1974, a study group on anorectal anomalies was formed in Japan to collect cases enough to undertake further investigation on the classification of anorectal anomaly. A registration form was defined in that year with standardization of technics and indications for clinical and roentgenological investigations. Through studies of the group, some aspects on the classification was reported on the Journal of Pediatric Surgery in 1982 with comments to the "International" classification. Recently, the study group also arranged a standard for the clinical assessment of the function of the anus and published it in the Journal of the Japanese Society of Pediatric Surgeons in 1982. Approximately 800 cases have been collected and analysed by the study group to date. Group study will continue to propel studies on anorectal anomalies and to improve results of surgical treatments.

Anal Canal↗