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Biomedical subjects

M S Clark

Publications and source records attributed to M S Clark.

At least 91 records · Page 5Linked to original sources
PubMed1984

Sublingual gland salivary fistula and sialocele.

A case of cutaneous salivary fistula and sialocele in the submental area, arising from the sublingual gland, is reported and its etiology, development, and management are discussed. The entity of plunging ranula is compared to the lesion the case presented, and the literature regarding this lesion is reviewed. The successful surgical treatment of this case supports the theory that the sublingual gland is the source of the disorder. The effect of the altered salivary function on the adjacent submandibular gland and duct presented an operative complication.

Child↗
PubMed1984

Record keeping in two types of relationships.

On the basis of a distinction between communal and exchange relationships (Clark & Mills, 1979; Mills & Clark, 1982), the following predictions were made: (a) Members of exchange relationships would keep track of individual inputs into joint tasks and (b) members of communal relationships would not. These hypotheses were tested in three studies. In each study, subjects worked on a task with a partner with whom they (a) desired or had a communal relationship or (b) desired or had an exchange relationship. The task involved locating and circling number sequences in a large matrix. Whether subjects used a pen of the same or of a different color from that used by their partner served as the dependent measure. If partners worked with pens of the same color individual inputs wee obscured. If they worked with different color pens, individual inputs were clear. Given this, if the proportion of subjects in a condition choosing different color pens was greater than 50% (chance), it was taken as evidence that subjects in that condition were trying to keep track of individual inputs. If this proportion was less than 50%, it was taken as evidence that subjects were trying to avoid keeping track of individual inputs. As predicted, in all three studies the proportion of subjects in the exchange conditions who chose a different color pen was significantly greater than 50% and was significantly greater than the proportion of subjects in the communal conditions who chose a different color pen. Also as expected, in no study was this percentage greater than 50% in he communal conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Orthotic management of scoliosis in Duchenne muscular dystrophy.

This study investigates the effectiveness of spinal supports and seating systems in retarding the progress of spinal curvature in Duchenne muscular dystrophy. The approach was to take six monthly radiographs of children with this disease attending the Regency Park Centre sitting in their wheelchairs with their usual spinal supports. Scoliosis progressed from a mean value of approximately 10 degrees for children under 12 years to a value of the order of 75 degrees by the age of 16 to 18 years. The rate of progression peaked at an average of more than 1 degree per month between 14 and 18 years. The curvatures observed using modular seats, spinal jackets and custom-molded seats were not significantly different from those observed using unmodified wheelchair seats.

Adolescent↗
PubMed1983

Anilides related to substituted benzamides. Potential antipsychotic activity of N-(4-amino-5-chloro-2-methoxyphenyl)-1-(phenylmethyl)-4-piperidinecarboxamide.

The substituted benzamides are used clinically both as antipsychotics and as stimulants of gastric motility. The antipsychotic effects are considered to be a consequence of their central dopamine antagonist properties, but there is evidence that the gastric stimulatory effects may be mediated by other mechanisms. Clebopride (3) is a substituted benzamide that although marketed for its stimulatory effects on gastric motility, is also a potent central dopamine antagonist. The corresponding anilide, BRL 20596 (4a), where the amide bond has been reversed, has been synthesized and found to lack gastric stimulatory activity. However, the potent central dopamine antagonist activity is retained, suggesting that benzamides and anilides have similar affinities for central dopamine receptors. The implications of the conformations adopted by benzamides and anilides at such receptors are discussed. Evidence is also presented that there is a further lipophilic binding site on such receptors for which the N-benzyl group is an optimal fit.

Animals↗
PubMed1983

Evaluation of rehabilitation services: the use of goal attainment scaling.

Goal attainment scaling (GAS) is a procedure for evaluating the effectiveness of intervention in human service programmes. The theory and procedure of GAS are described, and its strict requirements are discussed. An example application of GAS in a rehabilitation centre for physically disabled children is reported. Problems with the application of GAS as an evaluation procedure are discussed, and suggestions are made for dealing with these problems.

Evaluation Studies as Topic↗
PubMed1979

Substituted 3-amino-1,1-diaryl-2-propanols as potential antidepressant agents.

Following the discovery that 3-(dimethylamino)-1,1-diphenyl-2-propanol hydrobromide (1) possesses potent reserpine-prevention activity in mice, a series of analogues of 1 was synthesized and evaluated as potential antidepressant agents. Several routes to analogues of 1 were evaluated, the most generally applicable of which was the regiospecific ring opening of a suitably functionalized 1,1-diaryl-2,3-epoxypropane (obtained in three stages from the corresponding benzophenone) with the appropriate amine. The more interesting compounds of the series were evaluated for their propensity to cause undesirable peripheral anticholinergic effects, all compounds tested being markedly less active than imipramine on this parameter. On the basis of its good activity in biochemical and pharmacological animal models of depression, together with its relative lack of anticholinergic side effects, 1-(3-chlorophenyl)-3-(dimethylamino)-1-phenyl-2-propanol hydrochloride (20, BRL 14342) was chosen for further evaluation.

Animals↗
PubMed1976

Nomalike lesion in a patient with chronic lymphocytic leukemia. Review of the literature and report of a case.

A case in which a nomalike lesion occurred in a patient being treated for chronic lymphocytic leukemia has been reported. Differential diagnosis of noma from other oral gangrenous processes has been described. The pathophysiology of systemic disease and blood dyscrasias contributing to the development of the lesion has been discussed with reference to management and treatment. A review of the literature is included.

Agranulocytosis↗
PubMed1975

The effect of tryptophan and a tryptophan/5-hydroxytryptophan combination on indoles in the brains of rats fed a tryptophan deficient diet.

Rats maintained on a tryptophan deficient diet had reduced brain and serum tryptophan and brain 5-hydroxyindolacetic acid levels compared to controls. 5-Hydroxytryptophan and L-tryptophan administered to these deficient rats in a combination (5:95) produced a greater elevation of indolamines and tryptophan in the brain than either amino acid alone. In rats maintained on a normal diet the urinary output of 3-hydroxykynurenine was considerably reduced by treatment with the combination of amino acids as compared to tryptophan treatment. 5-Hydroxytryptophan reduced the induction of kynurenine synthesis in the liver produced by tryptophan, implying that it is capable of inhibiting the enzyme tryptophan pyrrolase in vivo. It is suggested that the possession by 5-hydroxytryptophan of tryptophan pyrrolase inhibitory properties may make the administration of the combination a better treatment of depressed patients exhibiting an indolamine deficit than either amino acid alone.

3-Hydroxyanthranilic Acid↗
PubMed1975

Successful treatment of mucocutaneous mucormycosis after dental extractions in a patient with uncontrolled diabetes.

A successfully treated case of mucocutaneous mucormycosis, after dental extractions in a patient with uncontrolled diabetes, has been reported. The pathophysiology of diabetes mellitus that contributes to the development of opportunistic fungal infections and gangrenous ulcerations, in a setting of decreased host resistance, has been discussed with reference to differential diagnosis and management. The consequences of operating on a patient with uncontrolled diabetes are evident.

Adult↗