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Biomedical subjects

M Rossi

Publications and source records attributed to M Rossi.

At least 595 records · Page 33Linked to original sources
PubMed1985

[Care of the terminal cancer patient. General treatment and psychological management].

The treatment of neoplastic patients in a terminal stage causes the surgeon who takes them in charge several problems, many of which are of a psychological nature. Such problems can be summarized as concerning the psychological attitude of the patient, the relationship between the patient and his family and the relationship between the patient and the hospital. These problems, together with others more specifically linked to the nature of the neoplastic disease, are not often easy to be solved by the single physician. Therefore, we propose to set up "Multidisciplinary groups for the study of untreatable neoplastic diseases", in order to assist the surgeon in the treatment of the last stages of the disease.

Anxiety↗
PubMed1985

[Action of aminoglycosides on platelet aggregation in vitro].

The authors tested the influence of gentamicin, spectinomycin dihydrostreptomycin on the ADP and epinephrine in vitro induced platelet aggregation. Our aim was to demonstrate if platelet aggregation in vitro had some influences by antibiotics. A reduction in platelet aggregability, strictly dependent from the used antibiotic dose was observed. We have studied platelet function thanks to Born's method, adding to PRP gradual therapeutics doses of antibiotics. The results showed a reduction of platelet function which was dose-depended, and, particularly, gentamicin seemed to be the most effective among aminoglycosides. An interference between these drugs and the ADP and epinephrine binding to specific platelet receptor sites is proposed.

Adenosine Diphosphate↗
PubMed1985

Circulating immunocomplexes and laryngeal carcinoma.

Serum levels of circulating immunocomplexes (CIC) were studied in a group of 37 patients with laryngeal carcinoma using two polyethylene glycol-precipitation methods. The preoperative values of this group showed higher levels of CIC when compared with 140 normal controls. No correlation was noted between tumoral stage, oncotype, and serum levels of CIC. Previous studies have shown that the status of several different types of human tumors can be monitored by serial determinations of levels of CIC. We believe that this technique can be used to evaluate the efficacy of therapy and to detect the recurrence of laryngeal carcinoma.

Aged↗
PubMed1985

Adult nephroblastoma with glomerular intracapillary deposits of IgM in the contralateral kidney.

A 43-year-old man who presented with hematuria had a nephroblastoma in the right kidney. After nephrectomy the patient was treated with irradiation and chemotherapy. Despite the development of pulmonary metastases he remained reasonably well for several years. He died of metastatic disease 8 years after presentation. Histological study of the contralateral kidney at autopsy revealed intracapillary glomerular deposits of IgM.

Adult↗
PubMed1985

[Intonation and organization of utterances].

Syntactic theories of intonation assume that intonation is congruent to syntax. It is, however, in the cases where it is not that intonation can restructure an utterance and become informative. In a first stage, we identify the prosodic units which play a part in the organisation of utterances. In a second stage, we examine how intonation contributes to the linear and hierarchical structure of utterances. The functioning of prosodic units in semantic and pragmatic organisation of the sentence allows us to bring to light syntactic constraints. This method seems the best way to evaluate the respective interactions of intonation with syntax and pragmatics. These syntactic constraints constitute formal marks which justify the content of prosodic rules (syntactic, semantic, accentual and rhythmic) which make it possible to predict or explain the intonation of utterances.

Humans↗
PubMed1985

Monitoring of NK-1 and NK-15 subsets and natural killer activity in kidney transplant recipients receiving cyclosporine.

NK-1, NK-15 subsets and natural killer (NK) activity were studied in 13 patients, before undergoing renal transplantation and in the post-transplant period. Pretransplant there was a significant reduction of NK activity with a defect in Vmax capacity in all patients. NK-1+ and NK-15+ cell number was normal or slightly increased in all subjects. Post-transplant evaluation under cyclosporine immunosuppression showed a quantitative reduction in NK cells while no changes in NK activity and killing activity have been seen. We conclude that in spite of a numerical decrease, NK activity was not affected by cyclosporine treatment.

Adolescent↗
PubMed1984

Adenosplenomegaly and prognosis in uncomplicated and complicated chronic lymphocytic leukemia. A study of 362 cases.

Presence and size of lymph nodes and spleen, graded from 0 to , in 362 patients with CLL observed from diagnosis were evaluated. Statistical analysis showed a relationship with age, sex, anemia and thrombopenia, leukocytosis, and outlined two different groups: the one without organomegalies , with higher mean age (67 years), female prevalence, and better prognosis; the other with adenosplenomegaly graded ++/ , with lower mean age (57 years), clear male prevalence, and worse prognosis. Survival results were statistically different only between groups 0/+ versus group ++/ . Important chronic diseases were present at diagnosis in approximately 25% of the cases, with a severely reduced survival (median, 27 months), close to that of the cases with anemia and/or thrombopenia (22 months). Therefore it seems that in every prognostic grouping system, complicated cases should be taken into account and grouped with the anemic and/or the thrombopenic ones. The following prognostic groups are proposed: I: low risk: cases without or with adenomegaly and/or splenomegaly + (65% surviving at 100 months); II: intermediate risk: cases with adenomegaly and/or splenomegaly ++/ (median survival, 70 months); III: high risk: cases complicated by chronic diseases, or with anemia and/or thrombopenia (median survival, 25 months).

Age Factors↗
PubMed1984

[Current diagnosis of venous diseases of the lower limbs].

The haemodynamic of venous circulation of lower limbs seems to be not yet fully understood and different methods are available to study clinical patterns of venous insufficiency, deep venous incompetence or venous occlusion. Simple and common methods as venography, venous doppler and plethysmography are frequently used but other method as impedance plethysmography, ambulatory venous pressure, photoplethysmography, isotopes and thermography can be used for research or clinical investigation. The techniques and the indications of these tests are reviewed and critically analyzed to evaluate the best approach to the patients with venous pathology.

Blood Pressure Determination↗
PubMed1984

[Isoenzyme fractions of serum and platelet lactate dehydrogenase in normal subjects].

We determined the isoenzymatic fractions of platelets and seric LDH in off healthy people (50 males and 50 females). We broken the platelets by triton X 100 (octylphenoxypolyethoxyethanol) in order to obtain the release of platelet LDH. The seric and platelet LDH isoenzymes were then separated by electrophoresis (Gelman sistem). We confirm the prevalence of LDH2 and LDH3 fractions in human platelets.

Adult↗
PubMed1984

The structure of 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone, an effective analog of colchicine.

-Methoxy-5-(2',3',4'-trimethoxyphenyl) tropone is an active analog of colchicine, a mitotic spindle inhibitor, which is missing the middle "B" ring. This compound crystallizes in the triclinic system, space group P1, with Z = 2; a = 10.135(2), b = 10.166 (4), and c = 7.863(2) A; alpha = 82.15(3), beta = 103.49(3), and gamma = 107.16(2); degrees and V = 750.7(4) A. The structure was solved by direct methods and refined by full-matrix least-squares to a final R = 0.063, using 2503 observed reflections and 271 parameters. Despite the absence of the middle ring, the conformation of the molecule is similar to that of colchicine, isocolchicine , and their derivatives. The troponoid ring is dissimilar to the phenyl ring in that it is not aromatic and does have alternating short and long bond lengths. The dihedral angle between the least-squares planes of the two rings is -57.4 degrees. Van der Waals surface representations of the analog and colchicine are presented to demonstrate the similarity and differences of these two molecules . The structural information of the analog is consistent with the interpretation of thermodynamic parameters which govern the interactions between brain tubulin and the analog.

Chemical Phenomena↗
PubMed1984

Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase.

5-AZA-2'-deoxycytidine-5'-monophosphate (5-AZA-dCMP) was tested as a substrate, and 5-aza-2'-deoxycytidine-5'-triphosphate (5-AZA-dCTP) was tested as an allosteric effector of purified spleen dCMP deaminase. Graphic analysis of the velocity of deamination of 5-AZA-dCMP versus its concentration gave a hyperbolic curve in which the estimated apparent Km was 0.1 mM. Since this curve was not sigmoidal and 5-AZA-dCMP at low concentrations stimulated the rate of deamination of the natural substrate, dCMP, it was proposed that the binding of 5-AZA-dCMP to the allosteric enzyme dCMP deaminase induced the R form. At substrate saturation, the rate of deamination of dCMP was 100-fold greater than that of 5-AZA-dCMP. dTTP inhibited the deamination of 5-AZA-dCMP with first-order kinetics. This inhibition was reversed by either 5-AZA-dCTP or dCTP. However, dCTP alone produced only a weak activation of the deamination of 5-AZA-dCMP in comparison to the potent activation when dCMP was the substrate. 5-AZA-dCTP was just as effective as dCTP for the allosteric activation of the deamination of dCMP. These results indicate that dCMP deaminase can play an important role in the metabolism 5-aza-2'-deoxycytidine nucleotides and may possibly modulate some of the pharmacological activity of this antimetabolite.

Allosteric Regulation↗
PubMed1984

[Correlation between electrocardiographic and echocardiographic findings in chronic aortic insufficiency].

Echocardiographic indices of left ventricular volume and mass and electrocardiographic indices of left ventricular hypertrophy have evaluated in 25 patients with chronic aortic regurgitation and in 10 normal subjects. When the patients with aortic regurgitation were subdivided in three groups with increasing evidence of left ventricular hypertrophy, the echocardiographic measures of left ventricular dimension and mass were also found to be increased, with statistically significant differences between patients and controls and among the three groups of patients as well. A specially constructed cumulative electrocardiographic index of left ventricular hypertrophy (Sokolow and Lyon's index plus Lewis' index plus strain pattern) is correlated with the left ventricular end-diastolic diameter (r = 0.65; P less than 0.001), cross-sectional area (r = 0.65; p less than 0.001) and mass (r = 0.75; p less than 0.001) better than the isolated electrocardiographic indexes.

Adult↗
PubMed1984

[Clinical renal transplantation: exfoliative urinary cytology in the evaluation of nephrotoxicity induced by cyclosporin therapy].

Cyclosporine significantly improved the results in organ allograft, nevertheless the drug's potential nephrotoxicity is still causative of problems in differential diagnosis between rejection and graft failure due to Cyclosporine in patients who undergo kidney transplantation. The authors evaluate the effectiveness of a simple method as Urinary Exfoliative Cytology (UEC) in a group of 38 patients who received a kidney allograft and post operative treatment with Cyclosporine. The cytological parameters studied were the following: cytology: cellularity, background, urotelial cells, tubular cells, red cells, polinuclear cells, monocytes, histyocytes, lymphocytes, plasmacells, casts (from 0 to 4+). In all the patients was associated the immunological evaluation--lymphocytes subpopulation markers and function--and Cyclosporine serum levels, together with the hematochemical parameters. In 6 patients with a rise of serum creatinine level the UEC evidentiated intracytoplasmatic eosinophile inclusions in the proximal tubular cells, picture never observed in over 5000 UEC examination of patients treated with post-transplant steroids and azathioprine immunosuppressive regimen. Moreover a complete renal function recovery followed the Cyclosporine dose reduction. The authors conclude that the UEC in kidney allograft is a safe, simple and useful method to assess the early renal damage due to Cyclosporine and to make differential diagnosis between nephrotoxicity and rejection.

Cyclosporins↗
PubMed1984

[The influence exercised by various temperatures on platelet aggregation in vitro].

To obtain a regular haemostasis is necessary that the platelets are numerically sufficient and functionally normal. Many factors influence on platelet aggregation; among these platelet shape, dimensions and volume. In our study we have analysed the temperature influence on platelet aggregation. In a group of 27 subjects we have demonstrated that the platelet rich plasma pre-incubation for 30 minutes in ice-bath does not modify the platelet aggregation capacity. On the contrary, the platelet rich plasma pre-incubation for 30 minutes at 37 degrees C reduces considerably the platelet aggregation, probably for the platelet volume reduction.

Adenosine Diphosphate↗
PubMed1984

[Usefulness of morphoscillography for the prognosis of the duration of aorta-femoral bypass in complex ilio-femoral arteriopathies].

The work has the purpose to draw some prognostic indications and therapeutical directions in the aorto-iliac arteriosclerotic disease, with reference to the preoperative arteriographic and morphoscillographic reports. In the 94 patients, corresponding to 140 limbs operated on, it was possible to remark the progression in worsening of the sphygmic activity in the limbs segments goes along with a deterioration of the surgical results, and the prognosis is particularly severe when the minimum values of total vascular caliber are remarked at thighs.

Adult↗
PubMed1984

[Evaluation of pressure and mechanical effects on the aggregation of human platelets induced by adenosine diphosphate in a system simulating a dialysis circuit].

Blood samples in sodium citrate 3.8% (ratio 1:10) of 15 healthy people were subjected to the pressure of 0, 50, 150 mm Hg respectively in a circuit operated by a peristaltic pump as during dialysis. The platelet aggregation induced by adenosine diphosphate (ADP) was determined in all cases. We found a significant reduction of the maximum percent aggregation of the samples exposed to the pressure of 150 mm Hg. We then suppose that a positive correlation exists between high pressure in the dialytic circuit and platelet damage.

Adenosine Diphosphate↗