Search PubMed⌕ Search

Biomedical subjects

M Rosenbaum

Publications and source records attributed to M Rosenbaum.

154 records · Page 9Linked to original sources
PubMedDate not supplied

Treatment as harm reduction, defunding as harm maximization: the case of methadone maintenance.

Despite numerous research studies demonstrating the efficacy of methadone maintenance treatment (MMT) in general and the value of retention in particular, the increasing defunding of this modality has compromised its potential. From 1990 to 1995 the lead author conducted a longitudinal research project to determine the impact of the cost of treatment on 233 San Francisco Bay Area study participants seeking, enrolled in, or defunded from MMT. This paper reports on selected findings from that study. Using variables of drug use, crime, gender and HIV risk, qualitative and quantitative results comparing those seeking treatment with those enrolled in treatment indicated that MMT functioned as a harm-reduction tool. When clients were defunded, however, drug use, crime and HIV risk increased and harm was maximized.

HIV Infections↗
PubMedDate not supplied

"Just say know" to teenagers and marijuana.

Despite increasing expenditures on prevention, government survey after survey indicates that marijuana use--which comprises 90% of illicit drug use--has not been eradicated among teenagers. Today's adolescents have been exposed to the largest dose of prevention in our history. After three decades of such efforts, one must ask why young people continue to use marijuana, and why drug education has failed to bring about a marijuana-free teenage America. Drug education falls short because it is based on a "no-use" premise, scare tactics and top-down teaching. Such programs do not educate, and may even be counterproductive for those who choose to say "maybe" or "sometimes," or "yes." Moreover, drug education, as has been the case since its advent, is based on politics rather than science--an enormous taxpayer drain with few demonstrative results. A new strategy for drug education requires a pragmatic view that accepts the ability of teenagers, if educated honestly and in ways they trust, to make wise decisions leading, if not to abstinence, to moderate, controlled, and safe use.

Adolescent↗
PubMedDate not supplied

Psychogenic seizures--why women?

The only consistent finding in studies of psychogenic seizures is the approximately threefold higher incidence in women. Therefore, why women? Charcot and Freud emphasized the sexual aspects of the seizure as has the current interest in childhood sexual abuse. From case studies and review of the literature the author believes that psychogenic seizures in women express rage, fear, and helplessness against the dominant and abusive male rather than sexual conflicts. Emphasizing the aggressive component of seizures does not minimize the traumatic effects of sexual abuse but rather includes it as leading to rage and helplessness.

Adolescent↗
PubMedDate not supplied

The acceptability, efficacy and safety of a new paediatric oral suspension of roxithromycin in respiratory tract infections.

A new paediatric formulation of roxithromycin was tested for acceptability, efficacy and safety in a multicentre, prospective, non-comparative trial in 210 children, aged between 2 and 8 years, with a variety of respiratory tract infections. Most children were diagnosed as having rhinobronchitis, acute pharyngitis or acute tonsillitis. A dose of 5-8 mg/kg/day (mean +/- SD, 5.92 +/- 1.12) roxithromycin was given orally for 5-10 days (mean +/- SDL 6.86 +/- 1.80). The formulation consists of a tablet for suspension in a small volume of water, administered using a spoon, twice daily. Acceptability was good, with only eight children refusing their medication because of the taste or because of vomiting. The method of administration was found to be convenient by 76% of parents. The clinical success rate was 89.1% in the intent-to-treat analysis. There were only 18 adverse events reported by 14 patients; of these, only 10 events (all gastrointestinal) in eight patients were classified as drug related. A total of eight patients discontinued treatment because of an adverse event, but in only four were the events drug related.

Administration, Oral↗
PubMedDate not supplied

[Comparative multicenter clinical study of flecainide and amiodarone in the treatment of ventricular arrhythmias associated with chronic Chagas cardiopathy].

Eighty one patients with ventricular arrhythmias associated with chronic Chagas disease participated in this multi-clinic study. Treatment with Amiodarone and Flecainide were compared using an open, parallel, randomized experimental design. Inclusion criteria required the selected patients to have 1,200 premature ventricular contractions per 24 hours and/or repetitive ventricular arrhythmias. Patients received 60 days of treatment with either Flecainide at 200 to 400 mg per day or Amiodarone 800 to 400 mg per day. This dosage was adjusted to the therapeutic response. Clinical and laboratory evaluations, electrocardiogram and 24 hour Holters were performed at study days: -7, -1, 8/9, 15/16 and 59/60. The percentage reduction of premature ventricular contractions at days 9, 16 and 60 were: 73.1%, 82.9% and 92.4% with Flecainide and 77.6%, 90.1% and 90.7% with Amiodarone. At the end of the study, Flecainide had induced a 92.5% reduction in couplets and 96.5% reduction in ventricular tachycardia. For the same parameters the percentages following Amiodarone were 95.2% and 92.6% respectively. Treatment was discontinued in three patients in the Flecainide group (two because of prolonged sinus node bradycardia and one because of sustained ventricular tachycardia). In the Amiodarone group, treatment was discontinued also in three patients (one because of sustained ventricular tachycardia and two because of severe photosensitive dermatosis). Although there were some differences in the results form center to center, the conclusions from the overall data indicate a similar, therapeutic effect with both drugs.

Adolescent↗
PubMedDate not supplied

[Effect of bromocriptine on secretion of the enzyme dopamine-B-hydroxylase (DBH) in patients with Parkinson's disease].

The activity of DBH enzyme was measured in plasma of 7 non treated patients suffering from Parkinson's disease; a 10 mg dose of Bromocryptine was administered per os to these patients. Attained results were compared to the enzyme activity in a group of control of 7 healthy individuals. It was pointed out that in patients suffering from Parkinson's disease the decrease of DBH level in plasma after the administration of Bromocryptine was of 32.6% +/- SE 4.4% while in the group of control the decrease was only of 15% +/- SE 4.9%. This decrease in the plasmatic level of the enzyme after the administration of Bromocryptine should be due to the marked antagonistic activity of Bromocryptine on pre-synaptic dopaminergic receptors. This should mean that peripheric pre-synaptic dopaminergic receptors are involved in the physiopathology of Parkinson's disease.

Bromocriptine↗
PubMedDate not supplied

Salvaging self: a grounded theory of pregnancy on crack cocaine.

A grounded theory was developed to describe how pregnant crack cocaine users perceived their problems and responded to them. A basic social psychological process, salvaging self, was identified from constant comparative analysis of in-depth interviews with 60 pregnant or postpartum women who used crack cocaine an average of at least once per week in pregnancy. Salvaging self included two phases, facing the situation and evading harm. Participants evaluated the value, hope, and risk of various responses to pregnancy. Actions included strategies of harm reduction and stigma management aimed at reducing damage to the fetus, their identities as individuals and mothers, and the maternal-child relationship. Personal histories and social contexts influenced the salvaging process.

Adult↗