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Biomedical subjects

M Rosen

Publications and source records attributed to M Rosen.

At least 253 records · Page 14Linked to original sources
PubMed1980

Glycopyrrolate in children. A comparison between the effects of glycopyrrolate and atropine administered before induction of anaesthesia.

The effect of intravenous administration of glycopyrrolate and atropine shortly before induction were compared in a double blind study in children. The study shows that glycopyrrolate, unlike atropine, administered before anaesthesia had little effect on heart rate. The heart rate changes at, and following, tracheal intubation were similar in both groups.

Atropine↗
PubMed1980

Maternal opinion about analgesia for labour. A controlled trial between epidural block and intramuscular pethidine combined with inhalation.

In a randomised controlled trial epidural analgesia with bupivacaine 0.5% (mean dose 112.8 mg) was compared with pethidine (mean dose 200 mg) and inhalational analgesia in primipara (28 and 30 mothers) and multipara (17 and 18 mothers). Mothers who had an uneventful pregnancy and labour and agreed to have either treatment were studied during labour and followed-up at interviews for 5 months after delivery. Epidural block was rated significantly superior in respect of pain relief and comfort, there were no differences between the groups in reports of perineal discomfort. Twice as many primipara required forceps delivery after epidural block. Very few mothers, in each group, reported something missing in their experience of childbirth. Two thirds of each group would use the same method again. Epidural block can therefore be recommended to uncommitted mothers as a satisfying and effective method of pain relief for labour.

Adult↗
PubMed1979

Comparison of buprenorphine and pethidine given intravenously on demand to relieve postoperative pain.

In a double-blind study of on-demand intravenous analgesia buprenorphine was found to be about 600 times as potent as pethidine. The incidence of side effects was similar with both drugs. The quality of analgesia, subjectively assessed, was good with both drugs using this method of administration. Provided that its low potential for abuse is substantiated, buprenorphine appears to be a powerful analgesic that may successfully be given intravenously on demand.

Adolescent↗
PubMed1979

Obstetric anaesthetic and analgesic services in Wales.

A survey of obstetric anaesthetic services in Wales covering 21 major units in which over 31 000 deliveries take place annually showed inadequacies in staffing at consultant and resident anaesthetist level. At least 20 additional consultant sessions were required to meet the recommendations of the Association of Anaesthetists of Great Britain and Ireland. If patients' requests for epidural analgesia are to be met some reorganisation and centralisation of facilities is needed.

Anesthesia, Epidural↗
PubMed1979

The Valved-Y-Cardiff Connector (V.Y.C. Con).

A disposable Y-connector for use when two infusions are connected to the same channula has been tested. The connector incorporates a valved tap in one limb which prevents retrograde flow into the infusion connected to that limb.

Infusions, Parenteral↗
PubMed1978

Perinatal mortality and morbidity associated with eclampsia.

Out of all the women who were delivered in Cardiff maternity units during 1965-74, 43 developed eclampsia, an incidence of 72/100 000 deliveries. The incidence in residents of Cardiff was 53/100 000 deliveries. None of the mothers with eclampsia died, but 10 of the 47 babies were lost, all but one having been born to women with antepartum eclampsia. The perinatal deaths were mainly associated with chronic placental insufficiency and preterm delivery. The extent to which the wide range of complex drug regimens used influenced perinatal outcome is not clear, although polypharmacy should be avoided. Because eclampsia is rare we advocate that its management should be planned and rehearsed and that a simple, standardised treatment regimen should be used. Failing placental function may be detected by monitoring fetal growth by ultrasound.

Adult↗