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Biomedical subjects

M Roland

Publications and source records attributed to M Roland.

At least 127 records · Page 7Linked to original sources
PubMed1981

Tubal sterilization by bipolar laparoscopy: report of 232 cases.

Two hundred thirty-two interval bipolar laparoscopic tubal sterilizations were performed in a university-affiliated community teaching hospital over a 3-year period. Advanced laparoscopy equipment, properly trained laparoscopists, and a system of delineated operating privileges were used; the complication rate was 0.8%. There was 1 intraoperative complication, and 1 postoperative complication that manifested itself on postoperative day 3. Neither complication was related to the electrocauterization. The cauterized segments of fallopian tube were intentionally transected in 195 (84%) of the patients. The equipment and methodology employed are discussed with comparison of bipolar electrocautery to mechanical nonelectric methods of laparoscopic sterilization, ie, bands and clips. The authors' preference for bipolar electrocautery tubal sterilization, using single-segment cauterization with tubal transection, is discussed.

Adult↗
PubMed1981

Effect of metronidazole and ampicillin on patients with gangrenous or perforated appendicitis. A comparative study.

A study comparing the effectiveness of metronidazole and ampicillin in preventing wound infection in gangrenous or perforated appendicitis without general peritonitis was performed. Metronidazole was given as suppository immediately after the operation (1 g) and the administration continued for 10 days. Initially, one suppository was given every 8 h for one or two days, thereafter one tablet (400 mg) every 8 h until 10 days after the operation. In the ampicillin group, ampicillin (4.0-6.0 g) was deposited intraperitoneally during surgery, followed by 1.0 g ampicillin every 6 h, first intravenously (or intramuscularly) for one or two days and thereafter as tablets. Of the 50 patients initially present in the study, 7 were excluded, 22 received ampicillin and 21 metronidazole. In the first group, 8 patients had perforated, and 14 patients gangrenous appendicitis. In the metronidazole group, the corresponding figures were 11 and 10. The mean hospitalization period after operation was 6.8 days for both groups. In the metronidazole group, wound infection was not observed. In the ampicillin group, 2 patients (9.1%) had wound infections.

Adolescent↗
PubMed1980

Tissue distribution of antitumor drugs associated with polyalkylcyanoacrylate nanoparticles.

Polymethylcyanoacrylate nanoparticles, polyethylcyanoacrylate nanoparticles, and free 3H-dactinomycin and 3H-vinblastine were studied with emphasis on their distribution pattern in rat tissues after intravenous administration. The adsorption of cytostatic drugs to polyalkylcyanoacrylate nanoparticles can modify drug distribution in tissues. Particularly with vinblastine, modification of drug disposition is important. Data are given concerning the formation and stability of nanoparticle--drug complexes. Polyalkylcyanoacrylate nanoparticles seem to be an interesting drug carrier owing to their size, structure, degradability, and drug sorptive properties.

Adsorption↗
PubMed1979

A seven-year follow-up of proximal gastric vagotomy. Clinical results.

During a 7-year period proximal gastric vagotomy (PGV) was performed in 565 patients. Of these, 210 patients with duodenal ulcer and 14 with dyspepsia without demonstrable ulcer at the time of operation were followed for 5--7 years. Sixty-six percent are symptom-free (Visick I), 23% have no complaints when they take certain dietary measures (Visick II), 3% are improved but still have periods of dyspepsia (Visick III), and 8% are failures because of recurrent ulcer (Visick IV). There were 4 duodenal, 3 pyloric, 5 prepyloric, and 7 lesser-curve gastric recurrences. There were one operative death (0.2%) and one major complication (0.2%). The side effects after PGV are mild, infrequent, and seldom of any significance to the patients. Diarrhoea and dumping are virtually eliminated. Body weight was stable during the whole period of study, and blood chemistry did not disclose any deficiency in haemoglobin, serum iron, or vitamin B12 which might be attributed to PGV. It is concluded that 5--7 years after proximal gastric vagotomy for duodenal ulcer there is a 10% recurrence rate, but the low risk of death and of severe complications and the lack of significant side effects more than outweight the high recurrence rate.

Body Weight↗
PubMed1977

Advances in tuboplasty.

Reconstructive oviductal surgery was performed on 205 private patients with primary and secondary infertility, who were selected from 1075 endoscopic examinations. Each patient underwent an infertility survey which included gamete formation, reception and deposition of gametes, nidation, post-coital, and semen analysis. Only those with tubal abnormalities, not responding to conservative therapy after a minimum period of six months following laparoscopic examination, were selected for tuboplasty. Spiral stents for fimbrioplasty and straight teflon tubing for mid-portion and cornua obstruction were employed. These stents were removed eight weeks post-surgery, under local anesthesia at the office. Of the 205 tuboplasties, 193 patients had sustained patency; 75 conceived; 7 aborted; and 1 had an ectopic pregnancy. Pregnancy occurred between 1 and 26 months after removal of the stents. Complications were very few. The use of Roland spiral teflon stents has resulted in a greater percentage in patency and pregnancy rates, as compared to those without use of stents.

Fallopian Tubes↗
PubMed1977

Light and electron microscopical studies of parietal cells before and one year after proximal gastric vagotomy in duodenal ulcer patients.

In 4 duodenal ulcer patients the morphology of parietal cells has been studied before and one year after proximal gastric vagotomy (PGV). The average basal gastric acid secretion of the 4 patients was reduced from 9.2 m.mol/h before to 0.9 m.mol/h one year after PGV (90% reduction). The reduction in acid secretion was not accompanied by changes in the morphology of the parietal cells. Light microscopical studies indicated that the average cell size was about the same before and one year after PGV. Electron micro scopical studies showed only negligible changes in the parietal cell ultrastructure.

Duodenal Ulcer↗