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Biomedical subjects

M Robinson

Publications and source records attributed to M Robinson.

At least 451 records · Page 25Linked to original sources
PubMed1977

Bone conduction speech discrimination: an indication of cochlear function in the immediate postoperative period.

We illustrate that the apparent sensorineural audiometric changes immediately following stapedectomy are not indicative of a true sensorineural type hearing loss. The cochlear changes evident by postoperative pure-tone and air conduction speech discrimination audiometric tests are not reflective of the true cochlear reserve when the procedure of bone conduction speech discrimination is used. We report 25 consecutive stapedectomy cases in which most of the one-week postoperative audiograms of stapedectomized ears revealed a mid- and high-frequency sensorineural pure-tone loss and a drop in the standard speech discrimination scores. The decrease in speech discrimination, however, was not verified when using the bone-speech discrimination test, using maximum masking in the opposite ear.

Audiometry↗
PubMed1977

Cobalt radiation to prevent reankylosis after repeated surgical failures: report of case.

This is the first reported case of the use of cobalt 60 radiation for the prevention of recurrent TMJ ankylosis after repeated surgical treatment had failed. Although radiation therapy is not usually indicated for benign conditions, 2,000 rads can be used safely to treat this crippling condition. Although no conclusions can be drawn from a single case, successful treatment of this patient is indicated by a 3 1/2-year follow-up.

Ankylosis↗
PubMed1977

Erythrocytes cultured from bone marrow.

The long-range objective of this study is in vitro tissue culture of bone marrow stem cells to produce erythroid cells of sufficient volume for clinical transfusion. Bone marrow from dogs and patients was cultured in 29 experiments lasting up to 15 weeks. Peripheral erythroid cells from dogs were cultured in three control experiments. Optimal tissue culture media was NCTC 109 augmented with vitamin B12, erythropoietin (EP), folic acid, and 9% fetal protein in 60 mm glass Petri dishes. Additional media and Step III EP was added at 2 to 4 day intervals. Peripheral erythroid cells in culture all were dead within 4 weeks. Marrow erythroic cells in culture proliferated as demonstrated by (1) Fe59 incorporation into cells during culture, (2) H3 thymidine uptake into cultured cells, (3) microscopic evidence of mitoses, and (4) total erythrocyte concentration in cultures far exceeding that of peripheral culture controls. For as yet unexplained reasons the total mature red blood cell concentration in the culture media remained essentially constant throughout the studies. This is a first step in achieving the ultimate goal of bulk erythrocyte production from tissue culture.

Animals↗
PubMed1975

A comparative enzyme histochemical and histological study of the effect of ischaemia and post mortem change on rat kidneys.

A histochemical study of the effect of ischaemia on rat kidneys showed that changes were demonstrable in adenosine triphosphatase, alkaline phosphatase and succinic dehydrogenase within 2 h. Further changes occurred with increasing time. The activity of acid phosphatase was little affected up to 24 h although at this time there was marked tubular disruption. Paraffin embedded H and E sections also showed marked changes within 2 h. Enzyme histochemical and histological changes in kidneys taken at varying periods after the death of the animal showed very similar changes to those in ischaemic kidneys. Differences were mainly in the rate and extent of the changes.

Acid Phosphatase↗