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Biomedical subjects

M Ringel

Publications and source records attributed to M Ringel.

46 records · Page 3Linked to original sources
PubMed1991

Regional cerebral blood flow during hypoxia-ischemia in the immature rat: comparison of iodoantipyrine and iodoamphetamine as radioactive tracers.

The indicator fractionation method was used to measure regional cerebral blood flow (rCBF) in immature rats, using either iodo-[14C]antipyrine (IAP) or isopropyl-[14C]iodoamphetamine (IPIA) as the radioisotope. Seven-day postnatal rats received a subcutaneous injection of either IAP (5 microCi) of IPIA (10 microCi), two minutes following which the animals were sacrificed and their brains prepared for quantitative autoradiography. Blood flows to cerebral cortex, hippocampus, striatum, thalamus and hypothalamus were comparable using the two methods, whereas blood flows to white matter structures were substantially higher (+ 64-85%) with IAP. Spatial resolution, especially of the gray matter structures, was greater with IPIA than with IAP. During cerebral hypoxia-ischemia (unilateral common carotid artery ligation and hypoxia with 8% oxygen), blood flows to all regions of the ipsilateral cerebral hemisphere were not different from control at 10 and 20 min. At 1-3 h of hypoxia-ischemia, blood flows were decreased in all analyzed structures of the cerebral hemisphere ipsilateral to the carotid artery occlusion, ranging from 7% to 40% of control values. A columnar or patchy distribution of preferential perfusion was seen within the cerebral cortex, striatum and thalamus, with IPIA, which corresponds closely to the pathologic pattern of injury seen within these structures of the immature rat. Such a preferential perfusion was not seen in hippocampus, in which metabolic factors (intrinsic vulnerability) most likely predict the distribution of hypoxic-ischemic brain damage.

Amphetamines↗
PubMed1990

[Management and organization of ambulatory medical care in a district].

An analysis is given of the management and organization of out-patient medical care in 15 districts and of the District Physician's responsibilities as well as the profile of a District Health Department. Compared to the situation of a decade ago, substantial changes in the territorial health organization have occurred (decentralization, formation of care areas, affiliation of small health facilities to bigger ones). The District Physician's scope of responsibility is increasingly determined by activities within the framework of the District Council, the proportion of organizational work has increased. In order to be able to fulfill his tasks the District Physician needs the support of a special Health Department. Skeleton regulations for out-patient medical care are necessary.

Ambulatory Care↗
PubMedDate not supplied

Changing disease patterns, shifting demographics: effects on laboratory services.

Laboratory services of the early 21st century will be heavily influenced by significant demographic redistributions and shifts in the incidence and prevalence of disease. A persistent influx of immigrants literally will change the face of the U.S. population. Persons born between 1946 and 1964 will reach middle and old age and will require testing for arthritis, diabetes, cardiac dysfunction, Alzheimer's disease, and stroke. Efforts to combat infertility will expand. Tuberculosis, wrongly assumed to be under control, will continue to proliferate. Testing will be needed for the millions of people living with AIDS and for the millions more infected or suspected to be infected with HIV. Cancer screening and information from genetic markers will widen. Public screenings will be routinely offered in assorted sites. As the national focus shifts from curing illness to promoting health, laboratory tests will assess healthy persons to a greater degree than ever.

Acquired Immunodeficiency Syndrome↗