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Biomedical subjects

M Revilla

Publications and source records attributed to M Revilla.

98 records · Page 6Linked to original sources
PubMed1990

[Total bone mineral content in premenopausal women].

Because of the controversy about the loss of bone mass in premenopausal women, we decided to study the total mineral bone content (TMBC), measured by dual-photon absorptiometry (DPA), a technique with low variation coefficient and high level of discrimination, in a group of 96 premenopausal women with a age range between 20-49 years, who were selected by homogeneous criteria of habits and life stile and body mass lower than 25. In all women, the TMBC were quantify in supine with the densitometer type Norland XR-26 and its value correlated with age following the "Pearson's test"; there were not statistical significance. We concluded that women in a fertile period of life do not lose bone mass as a TMBC, which mean the importance of obtaining the bone mass peak during the childhood and adolescency.

Absorptiometry, Photon↗
PubMedDate not supplied

Bone mineral content and body composition in postpubertal cyclist boys.

The effect of sports activity on bone mass was assessed by dual-energy X-ray absorptiometry in a group of 22 young cyclists aged 16.2 +/- 0.7 years. These athletes trained for 10 hours a week for over two years. Bone mass values were compared with those of 27 sedentary youngsters aged 16.9 +/- 0.3 years. There were no differences in total body bone mineral (TBBM) between groups. The leg bone mineral content (LBMC), body weight, and percentage fat were lower in the cyclists than in controls (p < 0.02, p < 0.01, and p < 0.001 respectively). No changes were observed when TBBM was normalized for weight. The changes observed earlier in LBMC disappeared when normalized for body weight. These results suggest that cycling does not stimulate bone mass in youngsters, and that the type, quality, and length of sports activity need to be defined.

Absorptiometry, Photon↗
PubMedDate not supplied

Metacarpal cortical thickness by computed radiography in osteoporosis.

Computed radiography was used to make radiogrammetric measurements of the second metacarpal in 240 women, 180 considered normal and 60 osteoporotic. These measurements had a coefficient of variation for the external diameter of 0.74% in normal women and 0.75% in osteoporotic women, and for the internal diameter of 2.4% and 2.03%, respectively. The group of women with osteoporosis was divided according to external diameter and internal diameter into a group with osteoporosis due to increased bone resorption (61.1%, normal external diameter and increased internal diameter), and osteoporosis due to deficient bone formation (26.1%, decreased external diameter and normal internal diameter). In the remaining subjects (12.8%), osteoporosis was attributed to both mechanisms. There was a significant linear regression between internal diameter and tartrate-resistant acid phosphatase concentration (p < 0.0001) in the group of increased bone resorption, which was absent (p = ns) in the group with deficient bone mass formation. No changes were observed in the size of the two groups. The low coefficient of variation of radiogrammetric measurements with computed radiography validate it as an accurate technique for bone mass studies. Moreover, it has the additional advantage of permitting determination of the proportion of women with osteoporosis due to increased bone resorption and/or deficient bone mass formation.

Acid Phosphatase↗
PubMedDate not supplied

Effect of adjuvant-induced arthritis on bone mass in rats and its prevention by non-steroid anti-inflammatory drugs (NSAIDs).

The effect of two propionic acid derived drugs, ketoprofene and butibufene, on the prevention of osteopenia due to adjuvant-induced anti-inflammatory arthritis, was studied in groups composed of 10 rats each. Another group of 10 rats was treated with a placebo and 20 non-treated rats served as controls. Once arthritis was evoked, propionic acid derived drugs were administered at equivalent doses, in the form of a local cream applied on the foot where arthritis was induced. The placebo group was treated with the cream without propionic acid derivatives. Rats were sacrificed at the end of the study and the femurs where arthritis was induced were dissected. Bone densitometry studies were conducted with double energy X-ray on these bones to calculate the bone mass. Bone mass was higher in the group treated with ketoprofene (p < 0.025) than in the butibufene and placebo-treated groups, and these 3 groups showed lower values than the control (p < 0.001). These results suggest that propionic acid derivatives can prevent the osteopenia induced by inflammation and the subsequent lack of limb use, an effect which may be related to its analgesic and/or anti-inflammatory effects. In addition, this may serve as a good model for the indirect measurement of the effectiveness of analgesic and/or non-steroid anti-inflammatory drugs in experimental animals.

Absorptiometry, Photon↗
PubMedDate not supplied

Etidronate versus clodronate in the prevention of postovariectomy bone loss. An experimental study in rats.

OBJECTIVE: We compared the diphosphonates etidronate and clodronate to find out which was more effective in inhibiting the loss of bone mass after ovariectomy in rats. METHODS: Five lots of female Sprague Dawley rats, each containing 15 rats (14 wks old; mean weight 290 g), were kept under identical living conditions (12 hrs of light and 12 hrs of darkness), habitat, and diet following the current norms of the European Economic Community. One lot was kept as a control; one lot underwent sham ovariectomy (Sham-OVX); and the remaining 3 lots were anesthesized and underwent double ovariectomy (OVX). One lot of ovariectomized rats was given etidronate by esophageal tube, 5 mg/kg/day (OVX-E); one lot was treated with intraperitoneal clodronate, 5 mg/kg/3 days (OVX-Cl). The remaining lot was not manipulated (OVX). The animals' right femurs were then dissected for measurements of the bone mineral content. RESULTS AND CONCLUSION: Bone densitometry revealed that loss of bone mass 2 months after ovariectomy in the OVX-Cl group was 2.3%, not differing from that of the control group; bone loss in the OVX-E group was 11.7%, significantly different from the control group and from the OVX-Cl group (p < 0.001). These results show that clodronate is superior to etidronate in inhibiting osteopenia after ovariectomy in rats.

Animals↗
PubMedDate not supplied

Serum osteocalcin and calcitropic hormones in a homogeneous group of patients with rheumatoid arthritis: its implication in the osteopenia of the disease.

Different mechanisms may play a role in the pathogenesis of the generalized osteopenia found in rheumatoid arthritis (RA). We measured the calcium, osteocalcin (BGP), parathyroid hormone (PTH), calcitonin (CT) and 25(OH)D3 levels as well as urine 24 hr calcium, Ca/Cr and OHP/Cr in a homogeneous group of 30 non-disabled patients (10 men, 8 premenopausal women and 12 postmenopausal women) recently diagnosed as having RA (disease duration 4 to 6 months). They had normal serum levels of vitamin K, were not on previous or present treatments known to interfere with calcium metabolism, and were not pregnant if females of fertile age. The group was compared with an age-matched control group of 32 healthy subjects (10 men, 8 premenopausal women and 14 postmenopausal women). We observed significantly decreased levels of 25(OH)D3 (29.9 +/- 9.9 vs 48.7 +/- 12.1 ng/mL; p < 0.005) and significantly increased levels of urine OHP/Cr (2.24 +/- 0.71 vs 1.56 +/- 0.82 mg/mg; p < 0.001) in the RA group. No differences in these two parameters were found between the three subgroups of RA patients. Male RA patients showed decreased levels of serum BGP (7.3 +/- 1.0 vs 8.2 +/- 1.7 ng/mL; p < 0.01). The remaining parameters did not differ significantly between RA patients and controls. These data suggest that the generalised osteopenia found in RA may be a consequence of increased bone resorption without a concomitant increase in bone formation, perhaps related to mechanisms inherent to the disease.

Adult↗
PubMedDate not supplied

[Chronobiological profile of arterial blood pressure and heart rate in a family group determined by automatic monitoring].

Over a week, blood pressure (systolic, mean and diastolic) and heart rate were determined in a family, by means of automatic, uninterrupted monitoring. The chronobiological profile for each family member was prepared in time series of various periodicities. An ample circadian component and a lesser circaseptan component were apparent. Clear phase differences were identified among the four cardiovascular variables studied. The chronobiological profile of the children was closer to that of the father than to that of the mother.

Adolescent↗