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Biomedical subjects

M Reinert

Publications and source records attributed to M Reinert.

At least 55 records · Page 3Linked to original sources
PubMed1979

[The clinical significance of challenge tests (author's transl)].

108 pollen-sensitive persons (positive skin test, positive history) and 40 latent pollen-allergic persons (positive skin test, but no conjunctival or nasal manifestations during the flowering season) were given intranasally increasing concentrations of pollen extract until a reaction occurred (itching, sneezing, running and blocked nose). 7.4% of the patients reacted to 0.001% w/v of the pollen extract, 56.5% reacted to 0.01, and 36% to a dose of 0.1% w/v. The corresponding figures for persons with latent allergy were 0.7, 5 and 30%; 62.5% reacted to 1.0 or 2.5% w/v of the extract. There was a relatively sharp division between doses of 0.1 and 1.0% w/v: persons who responded only to 1% concentrations invariably belonged to the group of latent allergy. 35 persons with positive skin tests to dust mites were divided into 3 groups: those with either a positive or a negative history of dust allergy and those concentrations of dust mite extracts (0.012, 0.12 and 1.2% w/v). Patients were considered to have latent allergy if they were sensitive to dust mite but were free from symptoms; or if they were sensitive to dust mite and pollen, but were symptom-free outside the flowering season. Although the group reacted slightly more often only to concentrations of 1.2%, the nasal response occurred on the whole with the same frequency with all three concentrations. In contrast to pollen allergy a positive intranasal dust mite test is not necessarily clinically relevant. Provocation tests are, therefore, not an infallible means to ascertain the presence of clinically relevant allergy.

Administration, Intranasal↗
PubMed1979

[Clinical characteristics of patients with pollen allergy (author's transl)].

134 patients with pollen allergy were studied in a medical practice. The frequency of hay fever was 56%, hay fever with cough 9% and pollen asthma 35%. The following differences were stated: 53.2% of the asthmatics but only 9.3% of patients with hay fever had a history of nonallergic bronchial irritation in the case of acute bronchitis, exercise or irritant gases. Asthmatics showed significantly more frequently positive skin reactions additionally to pollen. The distribution of age of onset of hay fever was similar in both groups. The prevalence of both diseases was the same up to the age of 20 years, after which it remained constant up to 29 for asthmatics and declined in hay fever. In patients with asthma and hay fever the two diseases began within the same year in 48,9%, asthma followed hay fever in 26,7% within 4, in 15,6% within 5--9 and in 8,6% within ten years or later after the begin of hay fever. It could be shown, that the frequency and the distribution of some characteristics of patients with pollen allergy of a medical practice are comparable to epidemiological findings and may be used for long time studies with the purpose to watch the transition of pollinosis to pollen asthma.

Adolescent↗
PubMed1976

Correlation between lung function and tracheobronchial collapse.

In 30 unselected male patients, bronchoscopic aspect and lung function parameters (notch in FEV1, FEV1/FIV1%, discrepancy between airways resistance and FEV1, club-shaped resistance curves) were correlated to determine the validity of lung function in the diagnosis of a central bronchial collapse. There were no strong correlations; only the club-shaped resistance curve and FEV1/FIV1% less than 60 were a little more often seen in the presence of central bronchial collapse. It is concluded from these results, and with regard to the known results from bronchial pressure measurements, that the functional parameters mentioned above are good indicators of a flaccid tracheobronchial system but not typical for a central bronchial collapse alone. Additional methods (bronchoscopy, bronchial pressure measurements) are needed to locate the major pressure drop and to select the adequate therapy (conservative in the case of pure peripheral or most mixed situations, chirurgical in special cases with pure central bronchial collapse). The reactions of a collapsible tracheobronchial system to bronchodilating drugs are described and their help in location of the major pressure drop is discussed.

Bronchial Diseases↗
PubMed1976

[Value of clinical history, skin testing and nasal allergen challenge in the diagnose of perennial rhinopathia].

In 64 out-patients suffering from perennial and partly from additional saisonal rhinopathia correlations between clinical history, skin testing (prick test) and nasal provocation tests were investigated. Most patients showed several positive skin tests to common allergens particular to grass pollen, house dust and mites (Dermatophagoides pteronyssimus). 123 nasal provocation tests were done. The correlation between history and skin test or nasal challenge was very strong for grass pollen (agreement in 78%), but very unsatisfctory for house dust and mites. Even in patients with positive skin tests to house dust and mites the history was only positive in 50-60%. Therefore the diagnose of perennial rhinopathia due to house dust and/or mites is only relevant if the nasal provocation gives a positive result. But if skin test are negative, nasal allergen challenge seldom showed positive reactions. For practical purpose nasal provocation is unneccessary if the skin test is negative. But the nasal provocation test don't give an absolutely right diagnose, because neither the environmental concentration nor the nasal threshold generally are known. Therefore, it is difficult to decide in many cases, if a reaction is positive because of testing a relevant allergen or because a latent allergen was overdosed. Finally the investigations show that simple and reproducible methods like the nasal forced expiratory volume in one second are sufficient to detect a positive nasal reaction.

Adolescent↗