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Biomedical subjects

M Reilly

Publications and source records attributed to M Reilly.

At least 91 records · Page 5Linked to original sources
PubMed1984

Beta-adrenergic and muscarinic cholinergic receptors: overlap in their genetic determination.

Significant positive correlation between the ligand binding values for beta-adrenergic receptors and those for muscarinic cholinergic receptors was found in five inbred strains of mice (r = 0.84) and in different vertebrate species (r = 0.99). Comparative analysis of analogous receptor studies done on various brain regions in other laboratories revealed high positive correlation between regional binding values for these two receptors. In conjunction with the work presented here, an overlap in the genetic determination of beta-adrenergic and muscarinic cholinergic receptors is suggested.

Animals↗
PubMed1984

Use of isotope bone scans and skeletal survey X-rays in the follow-up of patients with thyroid carcinoma.

We have evaluated the utility of isotope bone scans and skeletal survey X-rays in the periodic evaluation of patients known to have had thyroid carcinoma. Patient data were evaluated in 29 patients with known metastatic disease and 79 patients without known metastatic disease who were followed over a period of 3-12 years and who had coincident 131Iodide whole body scans, technetium pyrophosphate bone scans, chest X-rays, and skeletal surveys, at periodic intervals. The information gained for each patient, at a time when two or three of the major survey procedures were conducted coincidentally, was evaluated retrospectively for its impact on classification and management of the patients. Metastatic tumor was detected in most instances by 131I RAIU in the lungs or by chest X-rays. Six patients had proven bone metastasis. Four of these patients had positive 131Iodide RAIU in bones, and two were positive and two negative by pyrophosphate bone scan. Only one was positive by skeletal survey X-rays at the time metastases were first detected by bone scans. Nine of the patients with metastatic disease displayed abnormal bone scans, but six of these were determined to be false positives. Bone scans detected one poorly differentiated metastatic tumor which did not accumulate 131I. Bone scans were more sensitive than skeletal survey X-rays. Physical exam, chest X-ray, and I131 whole body scans detected all instances of metastatic carcinoma.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Renal cadmium content in the West of Scotland.

The trace element content of kidneys has been documented in very few international centres. Significant differences can be demonstrated between the cortical and medullary levels of calcium, zinc and cadmium. For the West of Scotland the values for the latter are similar to those found in Scandinavia. There are significantly higher cadmium contents in subjects who smoke and who have evidence of ischaemic heart disease.

Adolescent↗
PubMed1983

The properties of human fetal bone marrow stromal and hemopoietic cells.

The capacity of fetal bone marrow to form stromal cell colonies, granulocyte-macrophage colonies, stromal cell monolayers and to produce granulocyte-macrophage colony stimulating activity from these monolayers was evaluated in comparison to adult bone marrow. Granulocyte-macrophage colony formation on routine feeder layers was approximately equal in both cases. The fetal bone marrow colonies were larger in size than those from adult precursors. There were at least ten times more stromal cell precursors in fetal bone marrow than in adult bone marrow. The fetal bone marrow stromal cell monolayer formed within 7-12 days whereas adult stromal monolayer formation required 3-4 weeks. Fetal bone marrow stromal cell monolayer produced granulocyte-macrophage colony-stimulating activity (GM-CSA) effective only for fetal GM precursors, whereas adult bone marrow produces GM-CSA effective for fetal and adult normal and CML bone marrow.

Adult↗
PubMed1982

Mutagenesis testing of acetyl-tributylcitrate and epoxidized soybean oil.

Mutagenesis testing was conducted on two plasticizers commonly used in plastic wrap manufacture, acetyl-tributylcitrate and epoxidized soybean oil. There is no record of mutagenic testing using a bacterial screening method for these two compounds. The two plasticizers were screened using mutant strains of Salmonella typhimurium. The tests determined that they were not mutagenic.

Citrates↗
PubMed1982

Comparison of 30- and 50-mCi doses of iodine-131 for thyroid ablation.

We compared the utility of lower (30 mCi) and higher (50 to 60 mCi) doses of 131I used to ablate residual thyroid tissue after thyroidectomy for carcinoma. Whole body scans were done using 1 mCi 131I, 3 weeks after withdrawal of triiodothyronine. Patients had received ablation therapy within 3 days after scanning, and one or more subsequent scans were analyzed. Forty-eight patients were treated to ablate residual thyroid tissue that was presumed to be normal. Among 18 patients given the lower dose of 131I as outpatients, 15 had successful ablation and three needed a second administration; all 30 patients treated with the higher dose had successful ablation. Seventeen additional patients, presumed to have residual cancer, received 50 to 150 mCi; and six needed treatment. Although 1 dose of 50 to 60 mCi 131I provides more ablation, use of the usually effective 30-mCi dose for initial ablation is justified by the convenience of outpatient administration, the lower expense, and the lower whole-body radiation dose.

Ambulatory Care↗
PubMed1981

Migration of acetyl-tributylcitrate from plastic film into poultry products during microwave cooking.

Migration of the plasticizer acetyl-tributylcitrate from a plastic film into poultry meat and model food systems was studied. It was determined that this commonly used plasticizer migrated from the plastic film during microwave cooking by comparing the infrared spectra of the film used to cover the chicken to unused film. The peak at 1730 cm-1 was substantially reduced in the used film relative to a standard band at 2920 cm-1. Subsequent experimentation verified by chemical analysis that the compound was acetyl-tributylcitrate and that it migrated from the film into the chicken meat. Experiments using comminuted chicken meat and model food systems in a test cell indicated that the migration of the plasticizer was time related with a plateau being reached after cooking for 8 min. Studies with model food systems in the test cell indicated that the lipid portion of the system was responsible for migration and retention of acetyl-tributylcitrate in the sample. Increasing the lipid portion of the system tended to increase the amount of plasticizer found.

Animals↗
PubMed1980

Association of monocytic leukemia in patients with extreme leukocytosis.

Fifteen of 73 newly diagnosed patients with acute myeloid leukemia (AML), admitted to Mount Sinai Hospital between July 1977 and October 1979, presented with leukocyte counts greater than 100,000/microliter. Eleven of these 15 patients with hyperleukocytosis had myelomonocytic (AMML-M4) or monocytic (AMOL-M5) leukemia compared to 15 of 58 patients with lower white cell counts (p < 0.001). Identification of type of leukemia, using the FAB classification, was based on morphology and special stains, including myeloperoxidase, Sudan black B, periodic acid-Schiff and nonspecific esterase with and without inhibition by fluoride. The proportion of patients with splenomegaly is higher in those with hyperleukocytosis (73 percent) than in those with lower white blood cell counts (p < 0.001) regardless of cell type. Leukemic infiltration of the skin, gums and central nervous system was seen exclusively in patients with AMML and AMOL. The serum lysozyme levels were significantly higher for all patients with AMML and AMOL regardless of the white blood cell count. The mean serum lysozyme for M-4, M-5 patients was 59.7 microgram/ml compared to 18.9 microgram/ml in patients with other cell types (p < 0.0001). Patients with a white blood cell count less than or equal to 100,000/microliter had a complete remission rate of 69 percent compared to 47 percent for patients with higher white blood cell counts.

Humans↗